Hypophosphatasia (HPP) Market to Reach USD 2.14 Billion by 2034

Pune, India - December 2025 - The global Hypophosphatasia (HPP) Market, valued at USD 1.21 billion in 2024, is projected to reach USD 2.14 billion by 2034, growing at a 6.1% CAGR (2025-2034), according to Exactitude Consultancy. Increased awareness of metabolic bone disorders, improved genetic testing, and strong uptake of enzyme replacement therapy (ERT) are accelerating market growth.

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Market Summary
The Hypophosphatasia Market is expanding rapidly as early diagnosis and treatment options improve for this rare, inherited metabolic bone disease. HPP is caused by mutations in the ALPL gene, leading to reduced activity of tissue nonspecific alkaline phosphatase (TNSALP) and impaired bone mineralization.

Clinical severity ranges widely-from perinatal lethal HPP, infantile HPP, childhood-onset forms, to adult and odontohypophosphatasia. Symptoms include fractures, bone pain, respiratory complications, muscle weakness, rickets-like deformities, premature tooth loss, and mobility challenges.

The therapeutic landscape has been transformed by asfotase alfa (Strensiq), the first approved enzyme replacement therapy, which significantly improves survival in severe pediatric forms and enhances bone mineralization across multiple age groups. Diagnosis relies on serum alkaline phosphatase levels, PLP levels, radiographic findings, and expanded genetic testing.

North America and Europe lead due to higher diagnostic rates, newborn screening advancements, and strong ERT reimbursement systems. Meanwhile, Asia-Pacific shows the fastest growth, driven by improved rare disease awareness, better metabolic testing access, and expanding adoption of advanced therapies.

Key Takeaways
• 2024 Market Size: USD 1.21 Billion
• 2034 Forecast: USD 2.14 Billion
• CAGR: 6.1% (2025-2034)**
• Asfotase alfa remains the gold-standard treatment for all pediatric and select adult HPP cases
• Increasing newborn screening contributing to early diagnosis
• Asia-Pacific emerging as a high-potential growth region

Market Drivers
• Rising global awareness of rare metabolic bone disorders
• Strong clinical outcomes supporting long-term ERT use
• Growth in ALPL genetic testing and metabolic workups
• Early intervention benefits driving newborn and pediatric screening
• Expansion of rare disease funding and orphan drug incentives

Segmentation Snapshot
By Disease Type
• Perinatal Hypophosphatasia
• Infantile Hypophosphatasia
• Childhood Hypophosphatasia
• Adult Hypophosphatasia
• Odontohypophosphatasia

By Treatment Type
• Enzyme Replacement Therapy (ERT) - Asfotase Alfa (Strensiq)
• Supportive Therapies
o Pain Management
o Orthopedic Interventions
o Physical Therapy
o Dental & Orthodontic Care
• Emerging Therapies
o Gene Therapy Candidates
o Small-Molecule ALP Activators

By Diagnosis
• ALP Enzyme Testing
• Pyridoxal-5-Phosphate (PLP) Levels
• Radiographic / Skeletal Imaging
• Genetic Testing (ALPL Mutations)
• Newborn Screening

By End User
• Hospitals
• Genetic & Metabolic Disease Centers
• Pediatric Specialty Clinics
• Research Institutions
• Specialty Pharmacies

By Region
• North America (Largest Market)
• Europe
• Asia-Pacific (Fastest Growing)
• Latin America
• Middle East & Africa

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Recent Developments
• Expanded global access programs for asfotase alfa.
• Advancements in gene therapy targeting ALPL mutation correction.
• Increased rare-disease registry activity supporting epidemiology and treatment outcomes.
• AI-based diagnostic platforms improving early detection accuracy.

Expert Quote - Irfan Tamboli, Business Development Executive
"Hypophosphatasia treatment has advanced dramatically with enzyme replacement therapy improving survival and quality of life. Early diagnosis, supported by genetic testing, will continue to reshape the market and expand access to life-saving therapy."

Conclusion
The Hypophosphatasia Market is set for strong growth through 2034, driven by increased diagnosis, a robust therapeutic pipeline, and continued adoption of enzyme replacement therapy. Companies focusing on gene therapy, ALP activators, metabolic diagnostics, and rare disease care models will shape the next decade of treatment advancements.

This report is also available in the following languages : Japanese (低ホスファターゼ症市場), Korean (저인산혈증 시장), Chinese (低磷酸血症市场), French (Marché de l'hypophosphatasie), German (Hypophosphatasie-Markt), and Italian (Mercato dell'ipofosfatasia), etc.

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