openPR Logo
Press release

Peter MacCallum Cancer Centre and Cartherics Announce Collaboration to Develop Autologous CAR-T Cell Therapy for Ovarian Cancer

02-27-2023 09:20 AM CET | Health & Medicine

Press release from: Cartherics

/ PR Agency: Teraze Communications
Peter MacCallum Cancer Centre and Cartherics Announce

Melbourne, Victoria, Australia; 27 February 2023
Peter MacCallum Cancer Centre ("Peter Mac") and Cartherics Pty Ltd ("Cartherics") announced today they have entered into a Collaborative Development Program Agreement (CDPA) to develop Cartherics' proprietary autologous CAR-T cell therapy (CTH-004) for the treatment of ovarian cancer.
The clinical trial to be conducted by Peter Mac will be the first time a CAR-T cell therapy product containing the genetic modifications incorporated into CTH-004 has been tested in humans.
Ovarian cancer is Australia's most lethal gynaecological cancer, taking more than 1,000 lives each year. With a five-year survival rate of only 49%, there is an urgent need for research to give those diagnosed a better chance of survival.
Professor Simon Harrison, Director of the Centre of Excellence in Cellular Immunotherapy at Peter Mac, said "CAR T-cell therapy is a powerful immunotherapy that is uniquely tailored for each patient and which re-purposes their own T-cells to fight their cancer."
"It has emerged as a new treatment paradigm in blood cancer where it can produce complete responses, meaning their blood cancer has disappeared, in patients who have exhausted all other treatment options.
"The Centre of Excellence in Cellular Immunotherapy at Peter Mac is part of an international research effort to expand CAR T-cell therapy beyond blood cancer, and we're excited to be working with Cartherics to stage this first-in-human clinical trial in ovarian cancer."
Professor Alan Trounson, CEO of Cartherics, said "There are many patients needing help to control ovarian cancer and CAR-T therapy could be a game changer for them. It is our priority to ensure this potential therapy is tested in clinical trials as soon as possible."
Cartherics Board Advisor, Heather Hawkins said "As an ovarian cancer survivor and patient advocate, I am truly grateful for the vision, skill and dedication of the Cartherics team who are working tirelessly - seeking to improve the survival rates and the quality of life of women diagnosed with ovarian cancer. This announcement brings a real sense of progress and hope in this space."

There is an unmet need for new treatments options for patients with ovarian cancer as more than 80% of ovarian cancer patients experience a recurrence after initially having successful surgery and treatment.
The key aspects of the collaborative research are to develop clinical-scale manufacturing of CTH-004 and conduct a Phase I clinical trial. This program will be led at Peter Mac by the Centre of Excellence in Cellular Immunotherapy, with manufacturing being conducted at Peter Mac's manufacturing partners Cell Therapies Pty Ltd.
The clinical trial will initially enroll 6-12 patients with ovarian cancer who have failed prior treatment with chemotherapy. The primary goal of the clinical trial is to investigate the safety of CTH-004 in this patient population.
Cartherics and Peter Mac recently announced a collaboration for another Cartherics autologous CAR-T product, CTH-001. Based on pre-clinical data, the collaborators have agreed that Peter Mac will focus its efforts on CTH-004.
ENDS

12 Ferntree Pl, Notting Hill, VIC, 3168 Australia

Cartherics:
Christine Filippis
Phone: +61 419 119 866
Email: christine@teraze.com.au

About ovarian cancer
Ovarian cancer is a disease where some of the cells in one or both ovaries start to grow abnormally and develop into cancer. Approximately 314,000 new ovarian cancer cases and 207,000 deaths occurred globally in 2020. Ovarian cancer does not usually cause symptoms in its early stages and is often diagnosed at an advanced stage. It is most often treated with surgery and chemotherapy either on their own, or in combination. There is an unmet need for new treatment options for patients with ovarian cancer as more than 80% of ovarian cancer patients experience a recurrence after initially having successful surgery and treatment.
About Peter MacCallum Cancer Centre
Peter MacCallum Cancer Centre is a world leading cancer research, education and treatment centre and Australia's only public health service solely dedicated to caring for people affected by cancer. The centre has 3,300 staff, including more than 750 laboratory and clinical researchers, all focused on providing better treatments, better care and potential cures for cancer.
The Centre of Excellence in Cellular Immunotherapy at Peter Mac supports, develops and translates novel cell and gene therapies and is able to deploy its established suppliers and manufacturing partners such as Cell Therapies Pty Ltd to enable the use of these products in clinical trials for patients with cancer.
About Cell Therapies Pty Ltd ("CTPL")
Cell Therapies is a leading provider of onshore cGMP contract manufacturing and deployment services for cell and gene therapy products in the Asia Pacific. Building on more than 20 years' experience, and strategic partnerships within the ecosystem of the Peter MacCallum Cancer Centre, Cell Therapies provides a complete process development and GMP manufacturing and supply service from translational studies through to large-scale commercial supply. This unique capability positions Cell Therapies to serve as a single access point for regional deployment of cellular therapies for our clients.
About Cartherics
Cartherics is a privately held biotechnology company based in Melbourne, Australia that is rearming the body's immune system to fight cancer. It is developing cell-based immunotherapies for the treatment of cancer, with a portfolio of CAR-T and CAR-NK cell products. The Company's allogeneic ("off-the-shelf") cell platform is based upon induced pluripotent stem cells (iPSCs) generated from donated cord blood that can be differentiated into NK cells, T cells and other cells of the immune system. The iPSCs are genetically engineered to provide enhanced function for the derived NK and other immune cells.
The Company is also developing autologous CAR-T cell therapies. These use the patient's own immune system T cells, which are modified to be effective against the patient's cancer cells. CTH-004 is created by genetically modifying patient T cells to insert a chimeric antigen receptor (CAR) to target a marker (TAG-72) on ovarian cancer cells and delete genes that are involved in suppression of T cell function.

This release was published on openPR.

Permanent link to this press release:

Copy
Please set a link in the press area of your homepage to this press release on openPR. openPR disclaims liability for any content contained in this release.

You can edit or delete your press release Peter MacCallum Cancer Centre and Cartherics Announce Collaboration to Develop Autologous CAR-T Cell Therapy for Ovarian Cancer here

News-ID: 2949631 • Views:

More Releases from Cartherics

CARTHERICS TO PRESENT AT THE 2025 BIO INTERNATIONAL CONVENTION
CARTHERICS TO PRESENT AT THE 2025 BIO INTERNATIONAL CONVENTION
• Cartherics' Chief Operating Officer, Dr. Ian Nisbet, will be presenting at BIO on Monday 16th June, 2025 at 1.30pm (US EDT). Melbourne, Australia, 28 May 2025 - Cartherics Pty Ltd ("Cartherics" or "Company"), a biotechnology company focused on developing immune cell therapies for cancer and other diseases, announced today that Dr. Ian Nisbet, COO, will present at the upcoming 2025 BIO International Convention June 16-19 2025, in Boston Massachusetts.
CARTHERICS RAISES OVER $15 MILLION IN OVERSUBSCRIBED PRIVATE FINANCING ROUND TO ADVANCE CELL THERAPY PROGRAMS
CARTHERICS RAISES OVER $15 MILLION IN OVERSUBSCRIBED PRIVATE FINANCING ROUND TO …
• Financing round was significantly oversubscribed by existing investors and new private investors. • Funding will enable the Company to progress clinical trials of its lead CAR-NK cell therapy product, CTH-401, in ovarian cancer and expand its pipeline to additional disease indications. Melbourne, Australia, 1 October 2024 -  Cartherics Pty Ltd ("Cartherics" or "Company"), a biotechnology company developing immune cell therapies for the treatment of cancer and other diseases, is pleased to announce
CARTHERICS ENTERS AGREEMENTS WITH UNIQUEST, THE UNIVERSITY OF QUEENSLAND AND THE UNIVERSITY OF SYDNEY FOR ADVANCING INNOVATIVE CARDIAC CELLULAR THERAPY
CARTHERICS ENTERS AGREEMENTS WITH UNIQUEST, THE UNIVERSITY OF QUEENSLAND AND THE …
• Cartherics, UniQuest and The University of Sydney enter Technology Licence Agreement for Cartherics' iPSC cell line. • Cartherics, The University of Queensland and The University of Sydney enter Material Transfer Agreement to support development of iPSC-derived cardiomyocytes for the treatment of cardiovascular disease. Melbourne, Australia, 25 July 2024 - Cartherics Pty Ltd ("Cartherics" or "Company"), a biotechnology company developing immune cell therapies for the treatment of cancer, is pleased to announce that
CARTHERICS GRANTED EUROPEAN PATENT FOR MULTIPLE DEVELOPMENT CANDIDATES
CARTHERICS GRANTED EUROPEAN PATENT FOR MULTIPLE DEVELOPMENT CANDIDATES
Melbourne, Australia, 23 May 2024 - Cartherics Pty Ltd ("Cartherics" or "Company"), a biotechnology company developing immune cell therapies for the treatment of cancer, is pleased to announce that it has been granted its second European Patent from the family represented by the international patent filing WO2017088012. The European Patent No. 3708587 B1, titled 'Genetically Modified Cells and Uses Thereof,' secures a proprietary position for multiple development candidates in

All 5 Releases


More Releases for Peter

Under the Leadership of Peter Raventos, Peter Lead Emerges As One of the Best SE …
Image: https://www.abnewswire.com/upload/2025/03/d10eeb74712e3174001b868d7f7a38d7.jpg Under the leadership of Peter Raventos, Peter Lead has emerged as one of the most innovative SEO agencies in Barcelona [https://peterlead.com/]. The agency helps its clients achieve top rankings on Google. The agency's dedication to openness and customized approaches has produced search engine optimization solutions that appeal to customers and produce real results. Peter Raventos, a visionary entrepreneur and digital marketing expert, has established himself as a leading figure in
Peter Lead Emerges As One of the Best SEO Agencies In Spain Under the Visionary …
Image: https://www.abnewswire.com/upload/2025/03/dd344d85dafe378faee781c9afedfef1.jpg Under the leadership of Peter Ravento, Peter Lead has emerged as one of the most innovative SEO agencies in Barcelona [https://peterlead.com/]. The agency helps its clients achieve top rankings on Google. The agency's dedication to openness and customized approaches has produced search engine optimization solutions that appeal to customers and produce real results. Peter Raventos, a visionary entrepreneur and digital marketing expert, has established himself as a leading figure in
Terradepth Welcomes Peter Bardwick as CFO
Image: https://www.getnews.info/wp-content/uploads/2024/11/1732170594.jpg AUSTIN, Texas - Terradepth, a leading ocean data-as-a-service company, announced the appointment of Peter Bardwick as Chief Financial Officer, effective November 1, 2024. With over three decades of strategic, operational, and capital markets expertise, Peter has raised approximately $11 billion throughout his career and has been instrumental in leading two successful technology IPOs and a major public company turnaround. Peter's career began on Wall Street with Citicorp and Salomon Brothers.
New Hire: Attorney Peter Hobson
TAMPA-FL (June 10, 2016) Peter J. Hobson is the newest attorney at the law offices of McIntyre Thanasides Bringgold Elliott Grimaldi & Guito, P.A., who will be bringing more than 30 years of experience to the firm. Mr. Hobson was called to the bar in the state of Pennsylvania Bar in 1981 and then Florida in 1983. His legal practice includes trial law, family law, commercial litigation, criminal defense, sports
Peter Gabriel Tickets for Peter Gabriel New Blood Tour 2011
Peter Gabriel, born 13 February 1950, is an English singer, musician and songwriter who rose to fame as the lead vocalist and flautist of the progressive rock group Genesis. After leaving Genesis, Gabriel went on to a successful solo career. More recently he has focused on producing and promoting world music and pioneering digital distribution methods for music. Gabriel was also awarded the Polar Music Prize in 2009 and inducted
Luxury German doghouses on Blue Peter
Paderborn, Germany February 2010 The Paderborn, Germany based label Best friend's HOME builds luxury and exclusive doghouses. After receiving lots of positive press worldwide the BBC invited the young company to their traditional family programme “Blue Peter“ to present two of their doghouses. In the show that aired on the 17th of February, Golden retriever Lucy and Blue Merle Border Collie Mabel immediately fell in love with the exclusive dog homes.