Press release
DelveInsight Evaluates a Robust RNA Interference Pipeline as Key 20+ Pharma Companies Set Foot in the RNA Interference Space
Key Takeaways from the RNA Interference Pipeline Report
• Over 20+ RNA interference companies are evaluating 90+ RNA interference pipeline therapies in various stages of development, and their anticipated acceptance in the RNA interference market would significantly increase market revenue.
• Leading RNA interference companies such as Alnylam Pharmaceuticals, Suzhou Ribo Life Science, Arrowhead Pharmaceuticals, Sylentis, Vir Biotechnology, Arbutus Biopharma, Silenseed, OliX Pharmaceuticals, Bio-Path Holdings, Janssen Pharmaceuticals, Eli Lilly and Company, Dicerna Pharmaceuticals, Amgen, Sirnaomics, Silence Therapeutics, Sylentis, Silence Therapeutics, Suzhou Ribo Life Science, Phio Pharmaceuticals, Amylon Therapeutics, Aro Biotherapeutics, DTx Pharma, BONAC Corporation, and others are evaluating novel RNA interference drugs candidate to improve the treatment landscape.
• Key RNA interference pipeline therapies in various stages of development include SR061, ARO-APOC3, DCR-PHXC, SYL-1001, Fitusiran, Zilebesiran, VIR-2218, AB 729, Antisense K-ras RNA gene therapy, OLX 101A, Lumasiran, Prexigebersen-A, JNJ-3989, LY 3561774, DCR-HBVS, Olpasiran, STP705, ARO-HSD, ARO-MUC5AC, RBD1016, ANGPTL3 siRNA, SLN124, JNJ-75220795, LY3819469, ARO-HIF2, SYL 1801, STP707, DRC-AUD, SLN360, SR043, SR044, PH 894, PH 762PF-06650833, Polyoxidonium, Remimazolam, OP-101, Rayaldee, OT-101, ADM03820, OLT 1177, NVXCoV 2373, DFV890, Crizanlizumab, MAS-825, NBT-NM108, Ambrisentan, Sargramostim, Gam-COVID-Vac, mRNA-1283, MP1032, Molnupiravir, M5049, Covifenz, INOmax, MW33, RNA convalescent plasma, LB1148, Mavrilimumab, and others.
Recent Breakthroughs from the RNA Interference Treatment Landscape
• In April 2022, Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced that the U.S. Food and Drug Administration (FDA) has accepted the Company's New Drug Application (NDA) for vutrisiran, an investigational RNAi therapeutic for the treatment of the polyneuropathy of hereditary transthyretin-mediated (hATTR) amyloidosis in adults. The FDA has set an action date of April 14, 2022, under the Prescription Drug User Fee Act (PDUFA), and the Agency has indicated that they are not currently planning an advisory committee meeting as part of the NDA review
• In November 2021, Arrowhead Pharmaceuticals Inc. announced that its collaborator, Janssen Pharmaceuticals, Inc., (Janssen) one of the Janssen Pharmaceutical Companies of Johnson & Johnson, has disclosed its collaboration with Arrowhead on investigational compound JNJ-75220795, which is in a Phase I clinical study
• In November 2021, Arrowhead Pharmaceuticals announced that it entered into an exclusive license agreement with GSK under which GSK will develop and commercialize ARO-HSD.
Request a sample and discover the recent advances in RNA interference treatment @RNA Interference Competitive Landscape Report @ https://www.delveinsight.com/sample-request/rna-interference-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr
RNA Interference Overview
RNA interference (RNAi) is one of several RNA silencing pathways that use small RNAs as guides for sequence-specific silencing. In C. elegans, RNAi was discovered and defined as sequence-specific mRNA degradation induced by long double-stranded RNA (dsRNA). RNA interference (RNAi) technology regulates mRNA stability and translation in nearly all human cells.
RNA interference (RNAi) is a conserved biological response to double-stranded RNA that mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids and regulates the expression of protein-coding genes. This natural mechanism for sequence-specific gene silencing has the potential to transform experimental biology and may have significant practical applications in functional genomics, therapeutic intervention, agriculture, and other fields.
Find out more about the RNA interference method and RNA Interference Pipeline Outlook Report @ https://www.delveinsight.com/sample-request/rna-interference-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr
RNA Interference Pipeline Analysis: Drug Profile
ARO-APOC3: Arrowhead Pharmaceuticals
ARO-APOC3 is a subcutaneously administered RNAi therapeutic that inhibits the production of Apolipoprotein C-III (Apoc-III), a component of triglyceride-rich lipoproteins (TRLs) such as VLDL and chylomicrons, as well as a key regulator of triglyceride metabolism. The company believes that decreasing Apoc-III hepatic production will result in decreased VLDL synthesis and assembly, improved TRL breakdown, and improved clearance of VLDL and chylomicron remnants. It is currently being researched as a possible treatment for severe
hypertriglyceridemia (SHTG), familial chylomicronemia syndrome (FCS), and mixed dyslipidemia. Arrowhead's RNA interference (RNAi) therapeutic is currently in phase III testing for FCS and phase II testing for mixed dyslipidemia and SHTG.
DCR-HBVS: Dicerna Pharmaceuticals
DCR-HBVS is a GalXC RNAi therapy being developed by Roche for the treatment of chronic hepatitis B virus (HBV) infection. Chronic HBV increases the risk of developing liver failure, cancer, or cirrhosis, a condition that scars the liver permanently. DCR-HBVS has the potential to contribute to the ultimate goal of achieving a functional cure in chronic HBV patients and is currently being studied by Roche as part of Phase II clinical trial in combination with other treatment regimens to induce functional cures in patients. Furthermore, it is being tested in phase I for chronic hepatitis B.
RNA Interference Therapeutics Assessment
There are approx. 20+ key companies which are developing RNA Interference therapies. The RNA Interference companies which have their RNA Interference drug candidates in the most advanced stage, i.e. Pre-Registration include Alnylam Pharmaceuticals.
Learn more about the emerging RNA interference pipeline therapies and RNA Interference Ongoing Clinical Trials @ https://www.delveinsight.com/sample-request/rna-interference-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr
Scope of the RNA Interference Competitive Landscape Report
• Coverage: Global
• Key RNA Interference Companies: Alnylam Pharmaceuticals, Suzhou Ribo Life Science, Arrowhead Pharmaceuticals, Sylentis, Vir Biotechnology, Arbutus Biopharma, Silenseed, OliX Pharmaceuticals, Bio-Path Holdings, Janssen Pharmaceuticals, Eli Lilly and Company, Dicerna Pharmaceuticals, Amgen, Sirnaomics, Silence Therapeutics, Sylentis, Silence Therapeutics, Suzhou Ribo Life Science, Phio Pharmaceuticals, Amylon Therapeutics, Aro Biotherapeutics, DTx Pharma, BONAC Corporation, and others
• Key RNA Interference Pipeline Therapies: SR061, ARO-APOC3, DCR-PHXC, SYL-1001, Fitusiran, Zilebesiran, VIR-2218, AB 729, Antisense K-ras RNA gene therapy, OLX 101A, Lumasiran, Prexigebersen-A, JNJ-3989, LY 3561774, DCR-HBVS, Olpasiran, STP705, ARO-HSD, ARO-MUC5AC, RBD1016, ANGPTL3 siRNA, SLN124, JNJ-75220795, LY3819469, ARO-HIF2, SYL 1801, STP707, DRC-AUD, SLN360, SR043, SR044, PH 894, PH 762PF-06650833, Polyoxidonium, Remimazolam, OP-101, Rayaldee, OT-101, ADM03820, OLT 1177, NVXCoV 2373, DFV890, Crizanlizumab, MAS-825, NBT-NM108, Ambrisentan, Sargramostim, Gam-COVID-Vac, mRNA-1283, MP1032, Molnupiravir, M5049, Covifenz, INOmax, MW33, RNA convalescent plasma, LB1148, Mavrilimumab, and others.
Dive deep into rich insights for drugs for RNA interference treatment; visit RNA Interference Treatment Landscape @ https://www.delveinsight.com/sample-request/rna-interference-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr
Table of Content
1. Introduction
2. Executive Summary
3. RNA Interference: Overview
4. Pipeline Therapeutics
5. RNA Interference Therapeutic Assessment
6. RNA Interference- DelveInsight's Analytical Perspective
7. Late Stage Products (Pre-Registration)
8. Vutrisiran: Alnylam Pharmaceuticals
9. Drug profiles in the detailed report…..
10. Last Stage Products (Phase III)
11. Cemdisiran: Alnylam Pharmaceuticals
12. Drug profiles in the detailed report…..
13. Early Stage Products (Phase I)
14. Drug Name: Company Name
15. Drug profiles in the detailed report…..
16. Preclinical and Discovery Stage Products
17. Drug name: Company Name
18. Drug profiles in the detailed report…..
19. Inactive Products
20. RNA Interference Key Companies
21. RNA Interference Key Products
22. RNA Interference- Unmet Needs
23. RNA Interference Market Drivers
24. RNA Interference Barriers
25. RNA Interference Future Perspectives and Conclusion
26. RNA Interference Analyst Views
27. RNA Interference Key Companies
28. Appendix
For further information on the RNA interference pipeline therapeutics, reach out RNA Interference Therapy @ https://www.delveinsight.com/sample-request/rna-interference-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr
Company Name: DelveInsight Business Research LLP
Contact Person: Yash Bhardwaj
Email: info@delveinsight.com
Phone: 9193216187
Address: 304 S. Jones Blvd #2432
City: Las Vegas
State: NV
Country: United States
Website: https://www.delveinsight.com/
About Us
DelveInsight is a Business Consulting and Market research company, providing expert business solutions for life science vertical and offering quintessential advisory services in the areas of R&D, Strategy Formulation, Operations, Competitive Intelligence, Competitive Landscaping, and Mergers & Acquisitions.
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