Revenues From Treatment And Management Of Proliferative Vitreoretinopathy Worldwide To Reach Nearly US$ 660 Mn By 2027-End

With the rise in emphasis on prevention and treatment of proliferative vitreoretinopathy (PVR), a serious ailment that leads to blindness despite repeated treatment, the requirement for vitreoretinal centers has gained importance worldwide. Prevention of PVR development at early stage RRD for preserving visual function in patients has become a primary agenda among medical researchers and clinicians. A recent Fact.MR analysis envisages the proliferative vitreoretinopathy market to reflect a modest 4.0% CAGR during the forecast period.

However, establishment of vitreoretinal centers for the provision of advanced ophthalmological procedures is considered impractical, on account of increasing social security costs - a key challenge faced by nations across the globe. In contrast, remarkable advances have been made in medical equipment, and ultra-wide-field scanning laser ophthalmoscope (Optos) is one such advancement. This equipment facilitates the provision of wide-field, noninvasive, and nonmydriatic images, and is being increasingly employed for diagnosis and follow-up of PVR treatment evaluation.

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Proliferative Vitreoretinopathy Market: Hospital Pharmacies Continue to Account for Bulk Market Shares

Hospital pharmacies are leading consumers in the pharmacy industry. Policymakers are becoming more aware about importance of offering effective pharmacy services coupled with safe and rational use of medications. In case of proliferative vitreoretinopathy, hospital pharmacies are considered to be radical asset of the modern pharmacy sector.

They are vital part of hospitals and clinics, ensuring safe, effective, and economic use of drugs. According to the study, hospital pharmacies will continue to account for bulk shares of the market in the period of forecast.
Injectables will remain preferred over other mode of administrations of proliferative vitreoretinopathy management drugs.

Treatment of PVR through intravitreal injectables has been considered beneficial as they delivery drugs directly to retina and vitreous. Simplicity of achieving intravitreal injection by doctors is a key factor driving adoption of this method.

Subretinal injection has been gaining ground in the treatment of PVR, as it directly affects the resident cells & tissues in subretinal space. However, requirement for highly proficient and stable operators for subretinal injection continues to prevail as a major concern in the healthcare sector.

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Advantages of deep learning in classifying Optus images in RRD have been observed to be slight, however the method has been deemed clinically imperative to achieve higher accuracy. It has been observed that multiple non-linear processing layers in deep learning approach can be leveraged for effective prevention and treatment of proliferative vitreoretinopathy by further studies.

Proliferative Vitreoretinopathy Market: North America Remains at the Vanguard

North America will continue to be at the forefront of the proliferative vitreoretinopathy market, with approximately two-fifth market revenue share estimated for the region by 2027-end.

Favorable government policies and reimbursements provided by the government, along with the occupancy of robust healthcare facilities are key growth determinants for growth of the proliferative vitreoretinopathy market in North America. Additionally, strong penetration of PVR management drugs such as "lornoxicam" has further supported demand for treatment of PVR in the region.

Recent studies state that high level of vascular endothelial growth factor (VEGF) have been detected in the fibrovascular tissues of the eyes, which has prompted use of anti-VEGF as the most effective & efficient management method, in patients with proliferative vitreoretinopathy.

Emergence and robust adoption of intravitreal pharmacologic agents, particularly drugs that inhibit the actions of VEGF, have directed focus of approach toward the proliferative vitreoretinopathy therapeutics from vision stabilization to vision improvement.

Improvement in the patient's visual acuity while undergoing RRD via utilization of anti-VEGF has been deemed more effective compared to improvements observed in the treatment using corticosteroids.

Proliferative Vitreoretinopathy Market: Potential of Systemic Anti-TNF? Treatment in Reduction of PVR to Influence Future Developments

Lack of effective prophylaxis or treatment has made proliferative vitreoretinopathy one of the most devastating complications witnessed in RRD.
TNFα has been implied in PVR development, which in turn necessitates blockade of this factor for reducing or preventing onset of proliferative vitreoretinopathy.

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However, systemic treatment of PVR using anti-TNFα entails several side-effects and risks, and employment of such drugs for PVR treatment is not yet justified. Researchers have sought indirect approaches for determination of effectiveness of anti-TNFα in protection against PVR development post-RRD surgery.

Despite sound principles on which the approaches are based, low prevalence of patients affected with RRD, chronic inflammatory diseases, and PVR has prevented researchers from drawing conclusions with regard to potential effectiveness of the anti-TNFα therapy as prophylactic treatment for preventing or reducing PVR incidences following RRD.

However, these approaches hold promise in promoting future in-vivo studies, and randomizing clinical trials in humans with the help of more preclinical research.

Proliferative Vitreoretinopathy Market: New PVR Development Suppression & Prevention Methods to Underpin Growth

Proliferative vitreoretinopathy, an inflammatory fibrotic disease, stems from inflammatory milieu post-RRD, which in turn prevents retinal healing.
Several studies aimed at suppressing or preventing the development of PVR are being conducted worldwide, with some of the recent ones elucidating effect of "substance P (SP)," and targeted use of non-steroidal anti-inflammatory drugs such as "lornoxicam."

Research carried out on lornoxicam has not only demonstrated successful improvement in the condition of retina and choroid, but also reduced frequency of membrane formation significantly.
Studies conducted on substance P have revealed that SP has the capability of inhibiting apoptosis, and epithelial-mesenchymal transition (EMT) induced by TNFα caused, thereby suppressing or preventing development of proliferative retinopathy.

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