Organ-on-a-chip Market Future prospects and Recent Breakthroughs With Top Players Organovo, Hepregen, Hurel Corporation, Nortis

An organ-on-a-chip is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems, a type of artificial organ. The organ-chips are designed to accurately recreate the natural physiology and mechanical forces that cells experience in the human body. The chips are lined with living human cells and their tiny fluidic channels reproduce blood and/or air flow just as in the human body.

Organ-on-a-chip in comparison to the current costs of R&D per new drug. Cost estimates were derived from literature, because actual cost data are not publicly available.

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The main advantage of these chips is that they can be manufactured for a very low cost and this can allow to test the effect of a wide range of drug concentration on the efficiency of the medicine. This will allow organs on chip technology to considerably accelerate scientific research. In 2010, Harvard's Wyss Institute, led by Donald Ingber, produced the first successful chip, a lung model. Two years later Ingber's lab was included in a public-private collaboration tasked with creating 10 different human organs-on-chips.

A microfluidic chip is a set of micro-channels etched or molded into a material (glass, silicon or polymer such as PDMS, for PolyDimethylSiloxane). The micro-channels forming the microfluidic chip are connected together in order to achieve the desired features (mix, pump, sort, or control the biochemical environment).

Another PDMS 3D microfluidic heart-on-a-chip design is measured to generate 10% to 15% of uniaxial cyclic mechanical strains.

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Organovo, Hepregen, Hurel Corporation, Nortis, TissUse, Tara Biosystems, and AxoSim are some of the players engaged in organ-on-a-chip market. These companies are located in North America, with most being start-ups albeit with major funding and are expected to attain major commercial success in the near future.

Key Developments

Major players in the market are focused on various business strategies such as merger and acquisition, in order to enhance their market presence. For instance, in March 2018, BioIVT acquired Ascendance Biotechnology to expand its drug safety testing and toxicology portfolios.

Major players in the market are focused on various business strategies such as merger and acquisition, in order to enhance their market presence. For instance, in November 2018, BioIVT acquired Biological Specialty Corporation (BSC), which will expand its ability to offer fresh blood products.

Major players in the market are focused on various business strategies such as hosting conferences, events, and research symposium, in order to showcase recent research advances in the market. For instance, in August 2019, BioIVT, a provider of research models for drug and diagnostic development hosted research symposium titled, ‘“Innovation in Immuno-oncology: Breaking Down the Barriers’ at Massachusetts, U.S. This event highlighted research advances with implication for clinical practices and drug discovery of immune-oncology.

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