Designing multi-purpose vaccines
1. TRANSFORM a living bacteria (Mycoplasma pneumoniae) into a vaccine chassis
2. APPLY this vaccine chassis against bacterial diseases in livestock animals,
3. CONTRIBUTE to the reduction of antibiotics administered to farm animals
A well-rounded approach to science featuring ethics and communication
Successes across labs and offices
Each project partner contributed with tools, methods and approaches to the overall success of MYCOSYNVAC. To list a few examples, partners have:
- Engineered a new set of genetic tools to incorporate on/off switches in Mycoplasma for better and safer vaccines, showing good results in the lab and currently being analysed in vivo.
- Developed genome-scale metabolic, dynamic and whole-cell kinetic models of Mycoplasma and designed an open access modelling software tool (DMPy). The computer simulations revealed important bottlenecks and lead to crucial improvements for the large-scale production of vaccines
- Developed new methods that allow designing Mycoplasma that is not pathogenic, and to integrate entire 'genetic circuits' in the organism.
- Identified the surface proteins of several strains of Mycoplasma (to which the immune system reacts) and utilized those for future vaccine designs.
- Presented the project to the public across Europe, produced a short documentary film on Youtube and developed a free educational online and mobile game called "Battle for Cattle", along with self-learning and teaching materials.
- Developed a new genome engineering called MydelOrbit that allows fast knock in and knock out in any genome of interest, which may be considered for future use also in human therapy.
- Significantly increased an understanding of Mycoplasma, and developed novel technologies and results under consideration for their potential in developing novel veterinary vaccines
"Global challenges like antibiotic resistance are simply too big to tackle without investing in new ideas. Our work in re-engineering Mycoplasma is an example of the exciting opportunities cutting-edge synthetic biology techniques can fight the overuse of antibiotics in pigs and cattle. As well as farm animals, our work may one day combat human afflictions like pneumonia, which kills one in ten people that catch it in hospitals." said Luis Serrano, project leader and director of the Centre for Genomic Regulation in Barcelona.
MycoSynVac was a 5 year project that received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 634942.
Dr. Markus Schmidt
1030 Vienna, Austria
Biofaction is a research and science communication company based in Vienna, Austria. Biofaction has significant expertise in science communication, film production, technology assessment and the study of ethical, legal and social issues in a number of emerging sciences and technology (genetic engineering, synthetic biology, converging technology).
This release was published on openPR.
Permanent link to this press release:
Please set a link in the press area of your homepage to this press release on openPR. openPR disclaims liability for any content contained in this release.
You can edit or delete your press release Designing multi-purpose vaccines here
News-ID: 1983946 • Views: 558
More Releases from Biofaction KG
Bacteria as CO2 recycling powerhouse
E. coli can live and feed on formate & methanol: Scientists from the Max Planck Institute (Germany) have reached a significant breakthrough presented in their recent Nature Chemical Biology publication. Their research for EU project eForFuel has redesigned the model biotechnological bacteria Escherichia coli (E. coli) to live and feed on methanol and formate: a possibility that serves as a stepping stone towards future endeavors aiming at recycling CO2 into various
More Releases for Mycoplasma
Mycoplasma Detection Service Market Size & Growth Analysis Report, 2021-2027
Mycoplasma Detection Service Market is thoroughly, accurate and comprehensively assessed in a report focusing on market dynamics, market competition, regional growth, segment analysis, and key growth strategies. Report buyers will have access to proven market figures including global market size in terms of revenue and volume. (Get 15% Discount on Buying this Report) A full report of Global Mycoplasma Detection Service Market is available at: https://www.orionmarketreports.com/mycoplasma-detection-service-market/53929/ The Mycoplasma Detection Service key players in
Mycoplasma Diagnostics Market Opportunity Analysis by 2024
The global market for mycoplasma disorder featured the top five vendors, namely Thermo Fisher Scientific, Inc., F. Hoffmann-La Roche, Merck KGaA, Agilent Technologies, and Lonza Group accounting for over 68% of the overall market in 2016, observes Transparency Market Research (TMR) in a recent report. The high level of consolidation has ensued intense competition and increased focus of leading vendors on mergers and acquisitions, geographical expansion, and introduction of technologically
Mycoplasma Diagnostics Market to Reach US$ 1.35 Billion in 2024
Transparency Market Research states that the global mycoplasma diagnostics market will expand at a promising 10.6% CAGR over the period between 2016 and 2024, rising from a valuation of US$602.0 mn in 2016 to US$1.35 bn in 2024. The vast rise in the rate of prevalence of respiratory tract infections has emerged as the key growth driver for the global mycoplasma diagnostics market in the past few years. A report
Mycoplasma Diagnostics Market Demand is Increasing
Global Mycoplasma Diagnostics Market: Snapshot Mycoplasma diagnostics is a class of medical tests or examination conducted to evaluate nucleic acids or proteins at a molecular level. This aids in the early detection of mycoplasma contaminations in samples. Mycoplasma diagnostics is considered as a rapidly evolving and fast growing segment in the in-vitro diagnostic industry. Usually, usage of molecular diagnostics was limited due to necessity of vastly skilled specialists and high cost
Mycoplasma Diagnostics Market Analysis, Applications Share, Trends & Forecast to …
Global Mycoplasma Diagnostics Market: Snapshot Mycoplasma diagnostics is a class of medical tests or examination conducted to evaluate nucleic acids or proteins at a molecular level. This aids in the early detection of mycoplasma contaminations in samples. Mycoplasma diagnostics is considered as a rapidly evolving and fast growing segment in the in-vitro diagnostic industry. Usually, usage of molecular diagnostics was limited due to necessity of vastly skilled specialists and high
Global Mycoplasma Diagnostics Market Analysis
Albany, New York, May 3, 2017: This report on Mycoplasma Diagnostics Studies the current as well as future prospects of the market globally. The stakeholders of this report include companies and intermediaries engaged in the manufacture and commercialization of various mycoplasma techniques and products as well as new entrants planning to enter this market. This report comprises an elaborate executive summary along with a market snapshot providing overall information of