openPR Logo
Press release

Better Control, Healthier Yields: Biotech Process Analytical Technology

10-20-2011 10:29 AM CET | Health & Medicine

Press release from: Mettler-Toledo International Inc.

METTLER TOLEDO recently published a white paper entitled "Process Analytical Technology (PAT) for Biotech: A Review of Recently Reported Applications in Fermentation and Bioprocessing." The paper explores how Process Analytical Technologies, or PATs, help optimize fermentation and bioprocess actions critical to pharmaceutical, specialty chemical, commodity chemical, and bulk fuel development and manufacturing.

"PAT instrumentation, with applications from the laboratory to production scale, helps ensure bioprocesses are performing as designed to maximize batch yield and productivity," said Mr. Redman.

Effective screening and optimization for bioprocess development requires accurate monitoring and tight control of operating conditions. The METTLER TOLEDO literature review determined that PATs such as in situ monitoring are being used effectively to optimize bioprocesses in a manner unachievable by traditional methods of offline sampling.

Mr. Redman explained, "In our analysis, it became clear that for complex cell systems, where flocculation and aggregation alter biomass concentration, simplistic measurements such as turbidity and optical density do not capture the entire picture. Systematically applied PATs, on the other hand, enhance process controls for better consistency.

"Measurements such as Focused Beam Reflectance Measurement [FBRM] provide precise particle population measurements sensitive to changes in cell count, dimension and shape, each of which has been directly correlated to biomass. Morphologic change mechanisms and their kinetics are better quantified, which allows for real-time cell population control," he added.

Benefits were found across all processes reviewed, including fermentation, biocatalysis, peptide synthesis, and protein and peptide crystallization. Crystallization - whether protein or small molecule - requires consideration of process parameters that impact crystal nucleation, growth, and agglomeration. Real-time particle characterization has become standard PAT from early solubility curve determination to critical process optimization ensuring consistency in scale-up.

Advanced PATs help identify relevant parameters for optimizing chemical synthesis as well. Study results explored the relative influence of temperature and reagent concentrations on yield and selectivity while avoiding the cost and time delay involved in withdrawing, preparing, and analyzing samples on an ongoing basis.

"Across multiple processes and industries, PATs are being used to help ensure fermentation and bioprocessing exercises yield desired outcomes. The result is fewer pre-process experiments and more effective scale-up," concluded Mr. Redman. To download a complete copy of "A Review of Recently Reported Applications in Fermentation and BioProcessing" for free, visit [web address].

METTLER TOLEDO specialists Urs Groth, Fabio Visentin, Dominique Hebrault, Ben Smith, Des O'Grady, and Brian O'Sullivan assisted principal author Terry Redman in the white paper's creation.

METTLER TOLEDO's global network of technology and application consultants possess extensive research and industry experience supporting bioprocess development and scale-up. Visit METTLER TOLEDO at www.mt.com/autochem for information on our products/services and an extensive list of upcoming and on-demand webinars.

METTLER TOLEDO specializes in the area of precision instruments for professional use. METTLER TOLEDO laboratory instruments are used in research, scientific, drug discovery, and quality control labs, amongst many others in the pharmaceutical, chemical, food and cosmetics industries. METTLER TOLEDO comprehensive industrial solutions cover the various steps in a host of manufacturing processes at many of the same customers that laboratory serves. Solutions range from receiving raw materials through various manufacturing processes, in-line process control and end-of-line packaging control, to logistics and shipping. Increasingly, these solutions are fully integrated into the customer's IT environment, helping automate their workflows. In food retail, our offering for fresh food management ranges from receiving and pre-packaging, to in-store solutions for self-service departments, deli counters, and checkout terminals.

Mettler-Toledo International Inc.
Im Langacher, Zip Code 8606
Greifensee, Switzerland
E-Mail : ePublicRelations@mt.com
Phone : +41-44-944 33 85
Website : www.mt.com

This release was published on openPR.

Permanent link to this press release:

Copy
Please set a link in the press area of your homepage to this press release on openPR. openPR disclaims liability for any content contained in this release.

You can edit or delete your press release Better Control, Healthier Yields: Biotech Process Analytical Technology here

News-ID: 197068 • Views: 1225

More Releases from Mettler-Toledo International Inc.

New Digital Conductivity Sensors Monitor a Wide Range of Chemical Concentrations
METTLER TOLEDO Thornton, a leading provider of pure water analytical measurement solutions, announces the expansion of its conductivity sensor portfolio with the UniCond 4-Edigital sensors.The new four-electrode sensors have been designed to provide highly accurate measurement across a very wide range: a single UniCond 4-E measures from pure potable water to acid or base concentrations. Applications for the UniCond 4-E series include Clean-in-Place and desalination processes, deionization regeneration, industrial processing,
Short Video about Fast and Safe Installation of Tank Scales
A short video explains how the SafeLock features of the Pinmount Weigh Modules from METTLER TOLEDO help to do the installation right the first time. Each Weigh Module is delivered pre adjusted and ready to install. The SafeLock protects the Weigh Module against accidental overload and ensures safety during installation. There is no need for auxiliary devices such as dead stands or dummy load cells. Pinmount Weigh Modules are delivered as
Safe Automated Weighing of Potent Compounds in the Pharmaceutical Industry
METTLER TOLEDO today announced an upcoming webinar entitled “Safe Automated Weighing of Potent Compounds in the Pharmaceutical Industry" with special guest presenter Dr. Roy Helmy, Director of GlobalAnalytical Chemistry at Merck Research Laboratories in Rahway, NJ. In this free educational webinar, laboratory managers andprofessionalswho are concerned with safety or responsible for safety measures will be introduced to an efficient and effective solution for weighing small quantities of potent compounds. Dr.Helmy will
White Paper Discusses Maintaining Sustainable Quality with Weighing
In food production, accurate weighing can greatly impact the overall quality and integrity of the product, as well as enhancing a business's productivity and competitiveness. When a food manufacturer's weighing equipment is not verified, it risks inaccurate weighing and inadequate process quality, safety and compliance. In a new white paper, "GWP - The Global Weighing Standard for the Food Industry," the experts at METTLER TOLEDO have outlined how the global

All 5 Releases


More Releases for METTLER

Partnership Program between METTLER TOLDEO and Konica Minolta
Two world-wide renowned specialists in their field join forces: METTLER TOLEDO and Konica Minolta Sensing announce a strategic partnership in the field of Multi-parameter Analysis for the Flavours & Fragrances industry. The partnership will bundle the CM-5 or CR-5 Spectrophotometer from Konica Minolta with the Density, Refractive index and pH instruments from METTLER TOLEDO to provide a complete system for automatic quality monitoring of raw materials and finished goods. Trend towards
METTLER TOLEDO Posts New Optimizing API Production Processes Webinar
Mettler-Toledo has announced its latest on-demand webinar for the pharmaceutical industry. Optimizing API Production Processes explains the value of implementing in-line process analytical systems for API production. During the three major steps of API production -- chemical reaction, crystallization, and drying -- process control is central to maximizing yield and efficiency. Although lab analysis of samples provides accurate measurements, it is frequently too slow to allow timely actions and often means
METTLER TOLEDO Thornton Introduces Total Organic Carbon Sensor with ISM
METTLER TOLEDO Process Analytics Division announces the introduction of its 5000TOCi sensor with Intelligent Sensor Management(ISM). The new sensor is ideal for continuous, fast, and reliable monitoring of total organic carbon (TOC) levels in applications such as Water for Injection, reverse osmosis membranes, effectiveness of TOC destruct UV lamps, resin bed performance, organics shedding, and quality of final rinse water. With fast response and continuous on-line measurements, the 5000TOCi sensor ensures
METTLER TOLEDO launches the SmartCal reference substance
METTLER TOLEDO, a leading global supplier of precision instruments and services,has launchedthe innovative SmartCalreference substance,designed to verify and document moisture analyzer performance with a simple 10-minute test. SmartCal is a new quality control checkbased on a certified and traceable reference substance,whichverifies instrument performancewith a simple 10-minute moisture measurement.SmartCal fulfills the quality management system requirements of the food sector (BRC, IFS), the pharmaceutical industry (GMP, USP ) and also meetsISO9001. A User-friendly, 10-minute
METTLER TOLEDO's 2nd Annual Customer Council
METTLER TOLEDO's 2012 Customer Council is a two-day event featuring speakers, roundtable discussions, panels and activities for grocery retailers, industry experts and solution providers. This collaborative occasion offers opportunity to share challenges and best practices, and discover new ways to strengthen business. Introduced in January 2011, the Customer Council was created to provide a common forum to share ideas and learn from the best and brightest in the grocery industry, in
METTLER TOLEDO Presents Kinetic Experimentation Webinar
METTLER TOLEDO has expanded its leading webinar program with an interactive event focused on teaching chemical kinetic experimentation methods. The event will aid in the training of industrial chemists worldwide. METTLER TOLEDO will hold a webinar, entitled “Teaching Chemical Kinetic Experimentation,” on Wednesday, March 30, 2011. By demonstrating basic kinetics experiments, guest lecturer Professor John R. Sowa, Jr. will explore how the methodology he uses in chemistry instruction can help those