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Free Download: IR Spectroscopy Defines Catalyzed Reactions

09-23-2011 02:36 PM CET | Advertising, Media Consulting, Marketing Research

Press release from: Mettler-Toledo International Inc.

/ PR Agency: ePublicRelations@mt.com
METTLER TOLEDO is pleased to announce publication of a new white paper entitled “Metal Catalyzed Transformations.” As part of METTLER TOLEDO’s Recent Advances in Organic Chemistry series, “Metal Catalyzed Transformations” covers academic examples where in situ spectroscopy supplied critical but hard-to-obtain reaction parameters in a time- and resource-saving way. The paper is available for free download at www.mt.com/webaddress?.

[City, State/Country]—Authored by METTLER TOLEDO’s Adrian Burke and Dominique Hebrault, “Metal Catalyzed Transformations” reviews four recent academic examples where METTLER TOLEDO’s ReactIRTM in situ spectroscopy quickly supplied key reaction parameters—some of which had been lacking using other methodology—to researchers in highly usable graphic formats. ReactIR also allowed results collection in fewer experiments saving researchers’ time as well as materials cost.

Defining reaction start and end points—and ensuring reaction completeness—has historically presented a challenge to researchers in both academia and industry. However, IR spectroscopy, such as METTLER TOLEDO’s ReactIR, has been shown to help researchers describe mechanisms, pathways and kinetics of critical catalytic reactions. “The ability to thoroughly define these parameters is increasingly important due to the large number of complex manufacturing processes that rely on metal catalysts, which can be scarce, expensive, or both,” said Mr. Burke, head of Software and Segment Marketing for METTLER TOLEDO AutoChem. “Better process definition means more reliable reactions as well as reduced materials costs.”

The paper highlights the contexts in which ReactIR answered key reaction questions. In the first three studies, ReactIR was used to analyze reaction time-to-completion, the structure of reaction intermediaries, and reaction rate & mechanism, respectively. The fourth and final study demonstrated the power of combining structural information offered by the functional specificity of mid-IR with the kinetic information gained from in situ reaction-rate monitoring: Researchers determined that formation of an unexpected intermediary was negatively affecting racemization.

ReactIR in situ spectroscopy was shown to provide valuable information that enabled full description of the complex reactions. Results also proved complementary to other structural data such as NMR. Finally, the combination of ReactIR with METTLER TOLEDO’s iC KineticsTM software created a more robust methodology that allowed the study of reaction kinetics using fewer experiments than more traditional approaches.

“We hope this paper demonstrates how ReactIR in situ spectroscopy, when used either on its own or with other technologies, can help clarify reaction parameters in both academic and industry environments and ultimately promote more accurate, predictable and cost-effective manufacturing,” concluded Mr. Burke.

For more on ReactIR spectroscopy, or complementary technologies such as iC Kinetics or METTLER TOLEDO’s EasyMaxTM, please visit www.mt.com/autochem. To download the white paper itself, please visit www.mt.com/address

METTLER TOLEDO provides the enabling technology, software and people that can help build a seamless workflow to translate bench scale chemistry into a commercial process. For more than 20 years, our enabling tools and services have been a strategic resource providing critical information for thousands of development scientists and engineers. Companies have used that knowledge to accelerate the discovery, development and scale-up of new chemical processes spanning the chemical and biopharmaceutical industries. For more, visit www.mt.com

Mettler-Toledo International Inc.
Im Langacher, Zip Code 8606
Greifensee, Switzerland

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