highly effective therapies for various MDS types would support the Myelodysplastic Syndrome (MDS) Treatment Market growth are Celgene, Novartis, and Otsuka. Some of the other market players are Astellas, Astex, Acceleron Pharma, Onconova Pharmaceuticals

Major pharmaceutical organizations such as Celgene are investing major amounts in research and development of MDS specific drugs and many of their drugs are showing potential in the clinical trials as shown in the table no.1. Furthermore, in 2016, Opsona Therapeutics Ltd. received orphan drug designation for its OPN-305 humanized IgG4 monoclonal antibody for MDS treatment. Also, after Celgene lost its U.S. exclusivity for Vidaza, many generic formulations have entered in the market for Vidaza and Natco Pharma is also expected to launch generic version of Vidaza in 2017, which will further boost myelodysplastic syndrome treatment market.

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Increasing knowledge about the disease and its symptoms with advanced methods and techniques for early diagnosis and treatment for various forms of the disease is fuelling the market growth. The American Cancer Society estimates that, about 1/3rd of the MDS patients can rapidly advance to cancer of bone marrow cells called as acute myeloid leukemia. Thus, increased understanding of the pathology of the syndrome is directing the research towards developing more specialized and symptom based treatments with effective costs, so that majority of the MDS patients can avail these benefits.

The genetic transformations associated with the disease and biologics of the MDS is being explored. Diagnosis and treatment options are being researched at various standard cancer research centers. Mutations of TP53, TET2, and DNMT3A have been identified as possible MDS patients with shorter OS after allogenic HSCT which suggests the need of alternative treatment options than transplantation.

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Extensive research studies are being performed on existing treatment options such as chemotherapy, immune suppression, targeted therapy, stem cell transplant, and drugs to raise platelet counts such as Romiplostim (Nplate), which is used as a therapy for a disease called as Immune thrombocytopenic purpura (ITP). However, recent studies reports to have increased platelet counts in people with MDS according to the American Cancer Society.
Awareness initiatives to lead to early diagnosis and treatment

Furthermore, governmental organizations and drug manufacturing companies are spreading awareness about the disease with various ways, such as by providing funding and conducting awareness programs. MDS International Foundation is one such organization which is supporting the patients through various ways be it treatment or psychological support. Furthermore EvansMDS a funding initiative of the Edward P.Evans Foundation has awarded $45 Mn since 2011 for research specifically focused on MDS and AML.

Key players operating in the myelodysplastic syndrome treatment market include Celgene, Novartis, and Otsuka. Some of the other market players are Astellas, Astex, Acceleron Pharma, Onconova Pharmaceuticals, GlaxoSmithKline, Eli-Lilly, and CTI Biopharma.

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