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Urea Cycle Disorders (UCDs) Therapeutics - Pipeline Analysis 2018, Clinical Trials & Results | PhaseRx, Inc, Synlogic, Inc., Castle Creek Pharmaceuticals
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UCDs clinically present as recurrent episodes of hyperammonemia manifested by vomiting, lethargy and coma. The diagnosis of UCDs occurs during neonatal screening; while, some milder cases can diagnose later.
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The management of UCDs is based on minimizing the nitrogen load by decreasing dietary protein intake. Thus, patients generally consume a protein-restricted diet in order to minimize the production of ammonia from dietary nitrogen.
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The drug candidates in UCDs therapeutics pipeline include, but not limited to, SYNB1020 and mRNA therapeutics. Some of the major companies having pipeline drugs for UCDs includes PhaseRx Inc., Synlogic and Castle Creek Pharma.
• The report provides a comprehensive understanding of the pipeline activities covering all drug candidates under various stages of development, with the detailed analysis of pipeline and clinical trials.
• Pipeline analysis of drugs by phases includes product description and development activities including information about clinical results, designations, collaborations, licensing, grants, technology, and others.
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