Depression Therapeutics Market in Depth Analysis | Key Players are Pfizer, Inc., Eli Lilly and Company, AstraZeneca, Plc, Allergan Plc, GlaxoSmithKline Plc, Intellipharmaceutics International, Inc., Takeda Pharmaceutical Company Limited

Several potential blockbuster drugs are expected to lose patent protection during the forecast period. For instance, Fetzima, manufactured by Allergan Plc, is protected by three patents that are expected to expire in 2031, 2032, and 2023, each. Patent for Viibryd, manufactured by Allergan Plc is expected to expire in 2019. Major manufacturers receive approval of the U.S. Food & Drug Administration for commercialization of several antidepressant drugs. For instance, Levomilnacipran received the U.S. FDA approval in 2013, under brand name Fetzima by Forest Laboratories, Inc. Allergan Plc. and its partner Gedeon Richter Plc. received FDA approval for Vraylar (cariprazine) for treatment of manic or mixed episodes of bipolar I disorder and schizophrenia among adults.

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In 2017, Intellipharmaceutics International Inc. received approval from the U.S. Food and Drug Administration for quetiapine fumarate extended-release tablets in the 50, 150, 200, 300, and 400 mg strengths. The approved product is a generic equivalent of the branded product, Seroquel XR. Takeda Pharmaceutical Company Ltd. renamed its drug Brintellix (vortioxetine) to Trintellix (vortioxetine), in order to avoid misunderstanding and confusion between Brintellix and the anti-blood clotting therapy Brilinta (ticagrelor), in 2016.

Research and development by leading players is expected to boost growth of the global depression therapeutics market. GlaxoSmithKline plc collaborated with University of Cambridge and Janssen Pharmaceuticals to form a MRC Immunopsychiatry Consortium in 2017, to investigate the links between depression and inflammation. The trial studied whether or not an anti-inflammatory drug (an anti-IL6 antibody) could be used to treat depression. Allergan Plc's Vraylar (cariprazine) cleared phase III trial, while Rapastine is under phase II trial and is expected to receive approval by 2022. Allergan Plc. and its partner Gedeon Richter Plc. succeeded in phase 3 study of cariprazine for the treatment of major depressive episodes among adults, in 2017. Alkermes, Inc.’s ALKS 5461 is in Phase III clinical trials for treatment of major depressive disorder.

Various side effects such as increased suicidal tendency, sexual dysfunction and anxiety has limited the adoption of depression drugs. Moreover, due to these side effects manufacturers have been dragged in court many a times which has demotivated them to invest more in this market. For instance, in 2017, GlaxoSmithKline Plc was asked to pay US$ 3 Mn to a woman whose husband committed suicide after taking generic version of Paxil, an antidepressant drug, even though the generic drug was manufactured by another company, Mylan N.V. The jury ruled that since GlaxoSmithKline plc controls the drug’s design and label, applied to both generic and branded, the company is liable and will have to pay US$ 3 Mn to the complainant.

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Some major players operating in the global depression therapeutics market are Pfizer, Inc., Eli Lilly and Company, AstraZeneca, Plc, Allergan Plc, GlaxoSmithKline Plc, Intellipharmaceutics International, Inc., Takeda Pharmaceutical Company Limited, H.Lundbeck A/S, Otsuka Holdings Co.,Ltd., Apotex, Inc., Shionogi & Co. Ltd., Zhejiang Hua Hai Pharmaceutical Co., Ltd, and Chengdu Kanghong Pharmaceutical Group Co.,Ltd.

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