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Calibration Free Supersaturation For Crystallization

01-27-2011 03:37 PM CET | Health & Medicine

Press release from: Mettler-Toledo International Inc.

In this webinar, a method will be presented which facilitates the calibration free use of in situ ATR-FTIR spectra for the production and control of qualitative supersaturation trajectories.

Development and scale-up experiments are performed in a 100ml and 1L scale laboratory reactors. These lab reactor platforms, used in conjunction with Process Analytical Technologies (PAT), are used to develop and optimize the crystallization of both an Active Pharmaceutical Ingredient (API) and benzoic acid. The use of this methodology for assessing and solving laboratory based tech transfers and scale-up issues is also demonstrated.

The use of a commercially available software package is shown to implement an open loop feedback control strategy, used in conjunction with ATR-FTIR peak height values. The presented strategy demonstrates how qualitative supersaturation trajectories can be controlled to a specific set point and in turn ensure particle dimension and quality are not jeopardized in the tech transfer and scale-up of these processes.

The knowledge gained when coupled with in situ particle dimension information significantly increase process understanding and as a result minimal experimentation is required to output a desirable crystallization process.

METTLER TOLEDO specializes in the area of precision instruments for professional use. METTLER TOLEDO laboratory instruments are used in research, scientific, drug discovery, and quality control labs, amongst many others in the pharmaceutical, chemical, food and cosmetics industries. METTLER TOLEDO comprehensive industrial solutions cover the various steps in a host of manufacturing processes at many of the same customers that laboratory serves. Solutions range from receiving raw materials through various manufacturing processes, in-line process control and end-of-line packaging control, to logistics and shipping. Increasingly, these solutions are fully integrated into the customer's IT environment, helping automate their workflows. In food retail, our offering for fresh food management ranges from receiving and pre-packaging, to in-store solutions for self-service departments, deli counters, and checkout terminals.

Mettler-Toledo International Inc.
Im Langacher, Zip Code 8606
Greifensee, Switzerland
E-Mail : ePublicRelations@mt.com
Phone : +41-44-944 33 85
Website : www.mt.com

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