Metabolism Drugs Market – Insights With Major Key Players Merck & Co, Novartis AG, Amicus Therapeutics, AstraZeneca, Boehringer Ingelheim

The global metabolism drugs market size was valued at US$ 5,765.3 million in 2017, and is expected to witness a robust CAGR of 6.3% over the forecast period (2018 – 2026).

Metabolism diseases results from malfunctioning or inadequate function of the body’s original metabolism. Metabolism diseases can also have a genetic origin, as they can be caused by genetic birth defects as well. Metabolic diseases from genetic defects have low incidence and prevalence rate. Metabolism involves breaking down of carbohydrates, proteins, and fats present in the consumed food, to generate energy.

Furthermore, metabolism also involves excretion of nitrogen through urine, and breaking down or converting other substances and chemicals. This metabolism is carried out by certain enzymes and proteins designated for the respective role. However, metabolism functions improperly when enzymes and proteins are either not produced by the body (inherited disorders), or the produced enzymes do not function the way they are mean to.

Metabolic disorders occur due to buildup of proteins, lipids, glycogen, urea, calcium stones, and toxic substances among others. Each of these molecules have certain designated metabolic pathways, and metabolic agents (enzymes, proteins) at work. Inability of these agents to carry out their tasks cause buildup of the molecules in the blood and other places. Few examples of metabolic diseases include gaucher disease, hereditary tyrosinemia, hereditary orotic aciduria, and fabry disease.

Rising prevalence of metabolic diseases is expected to support growth of the metabolism drugs market over the forecast period

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Metabolic diseases is a wide category and there are several metabolism disorders caused due to clinically simple defects as well difficult to treat genetic disorders. For instance, obesity is most common type of metabolic disorder and is closely related to metabolic syndrome (a cluster of clinical conditions such as high blood sugar and triglycerides). According to the World Health Organization (WHO), over 650 million people aged 18 years and above were obese in 2016.

Another condition called lysosomal storage disease is a rare disorder, however, a significant number of people are affected with this disease. According to study published in Molecular Genetics and Metabolism Reports in December 2017, lysosomal storage disease has incidence rate of 1 in 4000 to 1 in 13,000 live births. Lysosomal storage disease consists of 60 genetic abnormalities with problematic enzyme function.

Moreover, other rare diseases such as Hunter syndrome (Mucopolysaccaridosis type II (MPS II)), though rare, are life-threatening diseases with no curative treatment available, thus patients are made to rely on available therapies. According to the National Institute of Health 2018 report, Frequency of MPS II is 1 in 100,000 to 1 in 160,000 in males. Increasing incidence of hunter syndrome is expected to boost the metabolism disease drugs market. For instance, in 2014, around 970 patients were enrolled in Hunter Outcome Survey (HOC), which increased to 1195 patients in 2017.

Manufacturers try to find potential revenue gaining opportunities in each and every disease segment by offering effective therapies. Though the prevalence of rare diseases is low, patients rely on therapies that are made available irrespective of their price. These drugs are difficult to develop, and in turn expensive, still manufacturers create therapies for chronic and difficult-to-cure rare diseases, selling them at higher prices.

Approvals to innovative therapies such as enzyme replacement therapy are expected to influence manufacturers to develop novel therapies in the market. This in turn, is expected to support the metabolism drugs market growth over the forecast period. The U.S. Food and Drug Administration (FDA) approved multiple drugs for gaucher disease. For instance, in 2010, FDA approved Vpriv (velaglucerase alfa), an enzyme replacement therapy (ERT), for type 1 gaucher disease. In 2012, Elelyso (taliglucerase alfa) and in 2014, Cerdelga (eliglustat) was approved by FDA for type 1 gaucher disease.

Moreover, research and development of novel therapies for treatment of rare metabolism diseases such as pompe, and others is expected to positively impact the metabolism drugs market growth. For instance, in October 2017, Amicus Therapeutics received orphan drug designation to ATB200/AT2221 from the U.S. FDA for the treatment of Pompe disease. Moreover, novel gene and RNAi therapies are also under research for treatment of these diseases.

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