openPR Logo
Press release

Viennese biotech company Marinomed demonstrates the benefits of its patented Marinosolv® technology

11-28-2018 05:04 PM CET | Health & Medicine

Press release from: Marinomed Biotechnologie GmbH

• Solubilization of the immunomodulator tacrolimus up to 200 times greater using Marinosolv®
• Bioavailability in the eye up to 15 times higher under laboratory conditions when compared to commercially available alternative treatments
• Findings published in the European Journal of Pharmaceutics and Biopharmaceutics
• Clinical trial for Tacrosolv, a tacrolimus-based product candidate against allergic conjunctivitis, planned for 2019

Vienna, 28 November 2018 – Marinomed Biotech AG (Marinomed) – an established Viennese biopharmaceutical company with a global presence – has published the results of scientific investigations that clearly demonstrate the benefits of its Marinosolv® technology platform. The study, which is available to read now in the European Journal of Pharmaceutics and Biopharmaceutics, shows that the solubility of the immunomodulator tacrolimus is 200 times greater in Marinosolv® than in water. This higher solubility could offer significant advantages for producers of tacrolimus-based medicines as well as patients – advantages which Marinomed is already exploiting with the development of Tacrosolv, its product candidate for the treatment of allergic conjunctivitis and dry eye syndrome.

Marinomed’s Chief Executive Officer Dr. Andreas Grassauer commented: “These are important results in terms of demonstrating the effectiveness of our Marinosolv® technology platform. This is the basis of our two product candidates Budesolv and Tacrosolv which we are developing for rapidly growing billion-dollar markets.”

Budesolv, a solubilized version of the corticosteroid budesonide developed for the treatment of allergic rhinitis, is already being tested in a pivotal clinical phase III trial, and Tacrosolv is expected to reach the phase II trial stage for the treatment of conjunctivitis in 2019. The next step for Tacrosolv will then be a pivotal phase III trial for allergic conjunctivitis and dry eye syndrome.

The Marinosolv® platform behind both product candidates was developed by Marinomed in 2015. At present, 40% of approved medicines and nearly 90% of therapeutic molecules currently in the research pipelines of pharmaceutical companies are poorly soluble.* Marinosolv® makes it possible to improve the water solubility of otherwise hardly soluble compounds – resulting in a lower drug dosage and a faster action. The Marinosolv® platform therefore opens up opportunities for the development of products that offer improved local availability of active ingredients in sensitive parts of the body such as the eyes and nose. The impact on the rest of the body is subsequently lower, meaning side effects could be reduced. Marinosolv® also enables preservative-free products to be manufactured with lower production costs.

The data on solubilized tacrolimus published by Marinomed’s research team demonstrates how effectively Marinosolv® can function. In addition to the improved water solubility of the immunomodulator using Marinosolv®, bioavailability was also significantly higher as a result. Different concentrations of tacrolimus were also tested using various forms of administration in the cornea of a model system. In comparison to tacrolimus applications that are already commercially available, the researchers found a 15-fold increase in concentration of the drug in the cornea when it was dissolved using Marinosolv®. Unlike the currently available products, which are taken orally or by injection, it could be simply administered as eye drops. No local, systemic side effects or histopathological changes were found. An additional finding was that tacrolimus, when dissolved in Marinosolv®, permeated into the posterior part of the eye in higher concentrations than the currently available products administered orally or by injection – a result which points to the suitability of Tacrosolv for the treatment of certain other ocular indications.

Commenting on Marinomed’s development objectives for its proprietary platforms, Dr. Grassauer said: “We are planning to capitalize on Marinosolv® to enter the multi-billion-dollar market for the treatment of allergies and eye diseases. All over the world, products from our other platform Carragelose® have already proved successful in treating the causes of colds and flu-like symptoms. We are going to expand both platforms to further strengthen our positions in extremely promising growth markets.”

* source: Acta Pharmaceutica Sinica B, September 2015 issue

Original publication: Pharmacokinetics of topically applied tacrolimus dissolved in Marinosolv, a novel aqueous eye drop formulation. C. Siegl, M. König-Schuster, S. Nakowitsch, C. Koller, P. Graf, N. Unger-Manhart, Y. Schindlegger, N. Kirchoff, C. Knecht, E. Prieschl-Grassauer, W. Sipos. European Journal of Pharmaceutics and Biopharmaceutics (2018), doi: https://doi.org/10.1016/j.ejpb.2018.11.015

About Marinomed Biotech AG
Headquartered in Vienna, biopharmaceutical company Marinomed Biotech AG focuses on developing innovative products for the airway and eye disease segment using patented technology platforms. The Carragelose® platform encompasses innovative patented products for the treatment of viral respiratory tract infections. Carragelose® is available as nasal and throat sprays and lozenges, which are sold in more than 30 countries around the world in collaboration with international partners. The Marinosolv® technology platform improves the efficacy of poorly soluble drugs specifically for the treatment of sensitive areas of the body such as the eyes and nose. For further information visit www.marinomed.com

Inquiries

Dr. Eva Prieschl-Grassauer
Chief Scientific Officer
Marinomed Biotech AG
Veterinärplatz 1
1210 Vienna, Austria
Tel. +43 (0)1 25077 4460
E-mail: eva.prieschl@marinomed.com
http://www.marinomed.com/

Corporate information:

Roland Mayrl
Managing Partner
Metrum Communications
Prinz-Eugen-Strasse 80/16
1040 Vienna, Austria
Tel. +43 (0) 1 504 69 87 331
E-mail: r.mayrl@metrum.at
http://www.metrum.at/

Scientific information:

Dr. Till C. Jelitto
Managing Partner
PR&D – Public Relations for Research & Education
Mariannengasse 8
1090 Vienna, Austria
Tel. +43 (0)1 505 7044
Mobile: +43 (0)664 226 9364
E-mail: jelitto@prd.at
http://www.prd.at

About Marinomed Biotech AG
Headquartered in Vienna, biopharmaceutical company Marinomed Biotech AG focuses on developing innovative products for the airway and eye disease segment using patented technology platforms. The Carragelose® platform encompasses innovative patented products for the treatment of viral respiratory tract infections. Carragelose® is available as nasal and throat sprays and lozenges, which are sold in more than 30 countries around the world in collaboration with international partners. The Marinosolv® technology platform improves the efficacy of poorly soluble drugs specifically for the treatment of sensitive areas of the body such as the eyes and nose. For further information visit www.marinomed.com

Inquiries

Dr. Eva Prieschl-Grassauer
Chief Scientific Officer
Marinomed Biotech AG
Veterinärplatz 1
1210 Vienna, Austria
Tel. +43 (0)1 25077 4460
E-mail: eva.prieschl@marinomed.com
http://www.marinomed.com/

Corporate information:

Roland Mayrl
Managing Partner
Metrum Communications
Prinz-Eugen-Strasse 80/16
1040 Vienna, Austria
Tel. +43 (0) 1 504 69 87 331
E-mail: r.mayrl@metrum.at
http://www.metrum.at/

Scientific information:

Dr. Till C. Jelitto
Managing Partner
PR&D – Public Relations for Research & Education
Mariannengasse 8
1090 Vienna, Austria
Tel. +43 (0)1 505 7044
Mobile: +43 (0)664 226 9364
E-mail: jelitto@prd.at
http://www.prd.at

This release was published on openPR.

Permanent link to this press release:

Copy
Please set a link in the press area of your homepage to this press release on openPR. openPR disclaims liability for any content contained in this release.

You can edit or delete your press release Viennese biotech company Marinomed demonstrates the benefits of its patented Marinosolv® technology here

News-ID: 1404357 • Views: 152

More Releases from Marinomed Biotechnologie GmbH

Marinomed Biotechnologie GmbH: New investment boosts global expansion / innovati …
Marinomed Biotechnologie GmbH will boost the successful expansion of its business activities with new investments. The Austrian investment fund "aws Mittelstandsfonds" is acquiring a share in the company and is providing significant financial means. The fund management was impressed with the successful international market entry of Marinomed's treatments for cold and influenza-like diseases. By further investing, the global roll-out of these products will be accelerated. At the same time, the
Marinomed Biotechnologie GmbH: French Nicox S.A. successfully bids for anti-vira …
Vienna – Marinomed Biotechnologie GmbH agreed to sell its promising anti-viral eye drop program to Nicox S.A. of France. The France-based international ophthalmic company acquires the entire program as well as all associated rights, data, contracts and information. In return Marinomed will receive up to € 5.3 Mio. The anti-viral eye drop program of Marinomed derives from the successful technology platform Mavirex® which exploits anti-viral effects of polymers from red
Marinomed Biotechnologie GmbH: Pharma Company Acquires Rights to Antiviral Produ …
MAVIREX® technology is the basis for five products against viral respiratory infections The rights to five medical products of the Viennese biotech company Marinomed have now been licensed to an international pharmaceutical company for the Chinese market. Besides three antiviral nasal sprays against common cold, influenza and colds in children, the deal also includes the two newest products from Marinomed: antiviral lozenges and a throat spray against viral throat infections.

All 4 Releases


More Releases for Marinosolv

Marinomed Biotech AG: Clinical validation of the Marinosolv® platform
Marinomed Biotech AG: Budesolv with a strongly decreased dose of the active ingredient compared to the marketed product Rhinocort Aqua shows pronounced efficacy already after first application – clinical validation of the Marinosolv® platform • Phase III study successfully completed preparing the ground for entering a multi-billion-dollar market • Even after the first application, Budesolv exhibits noticable efficacy • Allergic nasal symptoms markedly reduced within four hours • Six times less active compound than
08-07-2018 | Health & Medicine
PR&D
Vienna-based biotech company Marinomed obtains EU-wide certification for new col …
• New combination reduces blocked nose without a pharmaceutical ingredient while simultaneously combating viral airway infections • Patent application submitted for innovative formulation Vienna, 7 August 2018. Vienna-based company Marinomed Biotech AG (Marinomed) today announced it had secured EU-wide certification for a new product: a nasal spray that allows the decongestion of the nasal cavity without employing a pharmaceutical ingredient and tackles viral infections of the airways at the same time. The groundbreaking
Pascal Schmidt appointed CFO as Vienna based biotech firm Marinomed strengthens …
• Finance expert Pascal Schmidt joins the management team as of August 1, 2018 • Growth trajectory maintained with 84% increase in revenues in 2017 • Significant progression in the development of the Carragelose® and Marinosolv® platforms in 2017 Vienna, July 31, 2018. Vienna based Marinomed Biotech AG (Marinomed) strengthens its management team with the appointment of Pascal Schmidt as Chief Financial Officer (CFO) from August 1, 2018. This addition to the leadership team marks