Immunostimulatory Adjuvants Market - Size, Share, Outlook, and Forecast till 2026

Immunostimulatory adjuvants are specific class of compounds, which are added in vaccines to enhance immune response of body against specific antigen. Immunostimulators activate the immune system by accelerating activity of any of its components. An adjuvant is a component that potentiates the immune responses to an antigen and/or modulates it towards the desired immune responses. An immunologic adjuvant is defined as any substance that acts to accelerate, prolong, or enhance antigen-specific immune responses when used in combination with specific vaccine antigens.

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Immunologic adjuvants are majorly used to enhance vaccine potency by improvement of the humoral and/or cell-mediated immune response to vaccine antigens. This can be used to develop vaccine for prevention of various viral infections, which in turn is driving growth of the immunostimulatory adjuvants market. Therefore, development of vaccines with appropriate adjuvants is an attractive approach towards eliciting protective and long-lasting immunity in humans. The use of appropriate adjuvants allows vaccine formulations that selectively trigger innate immunity and/or adaptive immunity to obtain a desired type of antigen-specific immune responses. However, only a limited number of adjuvants is licensed for human vaccines due to complications regarding safety and toxicity, which is key factor restraining growth of the immunostimulatory adjuvants market.

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Key developments of Immunostimulatory Adjuvants Market

Market players are engaged in developing novel vaccines containing immunostimulatory adjuvants in order to meet increasing demand from healthcare sector. Furthermore, approval of novel drugs and guidelines regarding utilization of adjuvants by regulatory bodies is fueling growth of the immunostimulatory adjuvants market. For instance, in May 2018, the Centers for Disease Control and Prevention's (CDC) Advisory Committee published guidance on use of Heplisav-B (HepB-CpG), a new vaccine that protects against hepatitis B virus (HBV) infection. The new vaccine is one of five approved inactivated HBV vaccines. Heplisav-B contains a novel immunostimulatory sequence adjuvant. Two doses are administered just 1 month apart, making it an important option for prevention of HBV.

In February 2018, researchers from Kawasaki Institute of Industrial Promotion, The University of Tokyo, Tokyo Medical and Dental University, and Osaka Prefecture University, enhanced adjuvant properties of the RNA by utilizing the high immunogenicity of double stranded (ds)RNA. The dsRNA comprised mRNA itself and an RNA strand complementary to the poly A region of the mRNA. The study aimed to develop significant immune stimulation in a cell line and bone-marrow-derived APCs in vitro. Key players operating in immunostimulatory adjuvants market include Recenttec, Bayer AG, Adjuvance Technologies, Vical, Allergy Therapeutics, and BioCentury.

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