Pulmonary Arterial Hypertension Key Players – Arena Pharmaceuticals Bayer, Eiger BioPharmaceuticals, Gilead and Merck Market Analysis & Forecast to 2026

Pulmonary Arterial Hypertension

Overview

Pulmonary arterial hypertension (PAH) is a rare, fatal cardiopulmonary disease with an annual mortality rate of 15%. The disease is a subset (Group 1) within the World Health Organization’s (WHO’s) classification of the different types of pulmonary hypertension (PH). PAH is characterized by an abnormal rise in the resting mean pulmonary arterial pressure (>25mmHg compared with normal levels of around 14mmHg. ). This increased pressure is caused by pulmonary arterial obstruction due to endothelial dysfunction and vascular remodeling, and leads to increased resistance in the arterial blood vessels

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Top Companies mentioned

Actelion Pharmaceuticals (now key subsidiary of Johnson & Johnson)

Arena Pharmaceuticals Bayer

Eiger BioPharmaceuticals

Eli Lilly

Gilead

GlaxoSmithKline

Merck

Mochida Pharmaceutical

Nippon Shinyaku Co. Ltd

 Major Highlight

Since PAH is a progressive disorder, the pulmonary pressure keeps building up as the patient advances through the later stages of the disease, leading to reduced cardiac output, right heart failure, and ultimately, death.

The 5EU market is anticipated to grow the fastest of the three regions, recording a CAGR of 5.4%, while the US and Japan will each record CAGRs of 1.2% and 1.0%, respectively. At the end of 2026, the US will contribute around 67% of global sales, while the 5EU and Japan will account for 28% and 5% of global sales, respectively.

The higher sales numbers for the US can be attributed to the higher price of pharmaceuticals and the greater diagnosed prevalence of PAH in the region.

Scope

Overview of pulmonary arterial hypertension, including epidemiology, etiology, pathophysiology, symptoms, diagnosis, and treatment guidelines. 

Annualized PAH therapeutics market revenue, annual cost of therapy and treatment usage pattern data from 2016 and forecast for ten years to 2026. 

Key topics covered include strategic competitor assessment, market characterization, unmet needs, clinical trial mapping and implications for the PAH therapeutics market. 

Pipeline analysis: comprehensive data split across different phases, emerging novel trends under development, and detailed analysis of late-stage pipeline drugs.

Analysis of the current and future market competition in the global PAH therapeutics market. Insightful review of the key industry drivers, restraints and challenges. Each trend is independently researched to provide qualitative analysis of its implications.

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