Worldwide Business Survey: CD19 Therapeutics Market Size & Share, Growth, Trends, and Forecast 2017 - 2025

The report "CD19 Therapeutics Market - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2017 - 2025", has been prepared based on an in-depth market analysis with inputs from industry experts.

​This exclusive report will provide you with the market size and forecast (US$ Mn) for the global market and its segments for the period from 2015 to 2025 along with the growth rate (CAGR) from 2017 to 2025, considering 2016 as base year. In addition, drivers, restraints and opportunities, competitive landscape have also been covered under the current proposed table of contents, which will in due course help you to take strategic decisions with respect to the market.

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The human immune system is composed of various types of specialized molecules and cells, which are involved in complicated interactions and activities to assist immune response. Immunotherapies use body’s innate potential to precisely target a specific molecular antigen and produce an efficient immune response against cells that show disease symptoms. CD 19 acts on follicular dendritic cells and B-lineage cells. It plays an important role in autoimmune diseases and B cell malignancies. Hence, it is a potential target for a number of monoclonal antibodies (mAbs). For years, chemotherapy has been popularly acknowledged as one of the principle anti-tumor therapies to get rid of proliferative tumor cells. Anti-CD19 mAbs are being developed to treat CD19 autoimmune diseases and lymphomas. It is one of the most novel research areas in the field of drug discovery in the pharma industry. Several of the anti-CD19 techniques are presently being tested in clinical trials.

The global CD19 therapeutics market is driven by several important factors. Acute leukemia is regarded one of the most common forms observed in childhood malignancies, which accounts for roughly around 20% to 30% of all the pediatric malignancies depending on the age. According to CDC report, 2500 new patients are diagnosed with B-lineage acute lymphoblastic leukemia (B-ALL) in the U.S. each year. High incidence rates of non-Hodgkin’s lymphoma (NHL) have been confirmed in countries in the West. Additionally, the findings suggest that most of NHL subtypes are more predominant among men than women. CD19 is a 95-kDa transmembrane glycoprotein which belongs to the immunoglobulin (Ig) superfamily. Researchers suggest that CD 19 can act as a major positive response in regulating the B cells. Other factors driving the global CD 19 therapeutics market are rise in investment in health care by government and private organizations, increase in demand for minimal invasive surgeries, growing awareness about health, and early diagnosis of diseases. However, rise in cost of treatment, side effects associated with treatment, and lack of reimbursement policies in developing countries such as India, Singapore, and Brazil are likely to restrain the market.

The pipeline of the drug comprises products across four major classes. These are antibody drug conjugates, chimeric antigen receptor (CAR) T-Cell therapy (CAR-T therapies), engineered antibodies, and bispecific antibody (BsAb). Recent approval of BLINCYTO which is a CD19 targeting bsAb and advancements in the chimeric antigen receptor (CAR) T-Cell therapies has delivered a substantial boost to the global CD 19 therapeutics market. These innovative techniques focus primarily on hematological cancers, precisely B cell malignancies. Research suggests that several key players have entered into collaborations with other stakeholders to fund the commercial and clinical development of CAR-T therapies. For instance, KTE-C19, CTL019, JCAR015, and JCAR017 are examples of late stage products discovered through collaborative approach of top pharmaceutical companies.

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Other than pharma companies, the top research institutes involved in this area include the University of Pennsylvania, the MD Anderson Cancer Centre, the Memorial Sloan Kettering Cancer Center (MSKCC), the National Cancer Institute (NCI), and the Fred Hutchinson Cancer Research Center (FHCRC). Treatment of hematological malignancies is the primary focus of drug developers. However, approaches are also on track to use these therapies in the treatment of other symptoms including autoimmune diseases and solid tumors.

North America is the major market for CD19 therapeutics driven by rise in health care funding, presence of top players and availability of reimbursement policies. Asia Pacific is anticipated to grow rapidly in the next few years due to rise in geriatric population, increase in per capita income, and growing health care infrastructure.
The global CD19 therapeutics market is highly fragmented, with presence of large number start-ups and some of the top research organizations. Top players in this market are Bellicum Pharmaceuticals, Amgen, ImmunoGen, Affimed, MedImmune, Merck, and Novartis Juno Therapeutics.
The report offers a comprehensive evaluation of the market. It does so via in-depth qualitative insights, historical data, and verifiable projections about market size. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: Regional markets, technology, types, and applications.

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The study is a source of reliable data on:
Market segments and sub-segments
Market trends and dynamics
Supply and demand
Market size
Current trends/opportunities/challenges
Competitive landscape
Technological breakthroughs
Value chain and stakeholder analysis
The regional analysis covers:
North America (U.S. and Canada)
Latin America (Mexico, Brazil, Peru, Chile, and others)
Western Europe (Germany, U.K., France, Spain, Italy, Nordic countries, Belgium, Netherlands, and Luxembourg)
Eastern Europe (Poland and Russia)
Asia Pacific (China, India, Japan, ASEAN, Australia, and New Zealand)
Middle East and Africa (GCC, Southern Africa, and North Africa)

The report has been compiled through extensive primary research (through interviews, surveys, and observations of seasoned analysts) and secondary research (which entails reputable paid sources, trade journals, and industry body databases). The report also features a complete qualitative and quantitative assessment by analyzing data gathered from industry analysts and market participants across key points in the industry’s value chain.
A separate analysis of prevailing trends in the parent market, macro- and micro-economic indicators, and regulations and mandates is included under the purview of the study. By doing so, the report projects the attractiveness of each major segment over the forecast period.

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Highlights of the report:
A complete backdrop analysis, which includes an assessment of the parent market
Important changes in market dynamics
Market segmentation up to the second or third level
Historical, current, and projected size of the market from the standpoint of both value and volume
Reporting and evaluation of recent industry developments
Market shares and strategies of key players
Emerging niche segments and regional markets
An objective assessment of the trajectory of the market
Recommendations to companies for strengthening their foothold in the market

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