Axial spondyloarthritis (axSpA) Market and Forecast Analyst to 2024

ReportsWorldwide has announced the addition of a new report title Axial spondyloarthritis (axSpA) Market and Forecast Analyst to 2024 to its growing collection of premium market research reports.

Introduction

Axial spondyloarthritis (axSpA) is a chronic, systemic, inflammatory rheumatic disease that predominantly affects the spine and sacroiliac (SI) joints, leading to chronic back pain. The chronic inflammation can eventually result in new bone formation in the SI joints and spine, causing permanent impairment in spinal mobility. Ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA) are the two sub-diseases that comprise axSpA, the former of which is defined by radiographic evidence of inflammatory damage to the SI joints (radiographic sacroiliitis), whereas the latter is defined by findings of sacroiliitis on magnetic resonance imaging scans but without the detection of advanced sacroiliitis by conventional radiography.

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Although the etiology of axSpA remains unclear, the condition is inheritable and genetics play a major role, with mutations in certain genes, including the human leukocyte antigen B27 gene, known to be associated with an increased risk of developing AS. The initial signs and symptoms of the disease, including spinal pain and stiffness, are not specific to axSpA, therefore there is often a lag time between onset and diagnosis. Studies suggest that axSpA is most prevalent in Caucasian populations and AS is typically more common in male adults, whereas nr-axSpA occurs more frequently in females. Furthermore, axSpA is often associated with a series of extra-articular manifestations and co-morbidities, including uveitis, cardiovascular risk, and inflammatory bowel disease. As a result, direct medical spending on the diagnosis and treatment of these conditions intensifies axSpA’s economic impact.

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