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Global Oncolytic Virus Therapy Market & Oncolytic Virus clinical Trials Outlook 2022

07-07-2017 08:59 AM CET | Health & Medicine

Press release from: Kuick Resarch

Global Oncolytic Virus Therapy Market & Oncolytic Virus

Advancements in human genomics over the last two decades have shown that cancer is mediated by somatic aberration in the host genome. This discovery has incited enthusiasm among cancer researchers; many now use therapeutic approaches in genetic manipulation to improve cancer regression and find a potential cure for the disease.

The dominant cancer treatment modalities such as chemotherapy, radiotherapy, and even targeted kinase inhibitors and mAbs are limited by low efficacy, toxicity, and treatment resistant tumor subclones. Oncolytic viral therapy offers a novel therapeutic strategy that has the potential to dramatically improve clinical outcomes. Oncolytic virotherapy is an emerging bio-therapeutic platform based on genetic engineering of viruses capable of selectively infecting and replicating within cancer cells. Such viruses have been found to be both safe and to produce anti-tumor effects in a number of Phase I and II clinical trials. OV therapy holds the promise that it may function as a cancer vaccine strategy.

Looking beyond the expected clinical approval of oncolytic viruses as single agents, there is enormous scope for the development of more complex protocols to achieve superior treatment outcomes. Preclinical studies provide a very strong basis for this assertion, demonstrating numerous synergistic interactions that can overcome the various barriers constraining oncolytic viruses, such as the use of cell carriers to optimize virus delivery or of immunosuppressive drugs to enhance their intratumoral spread.

The recent FDA approval of the T-VEC (Imlygic, Amgen) for the local treatment of unresectable metastatic melanoma is the first clinical and regulatory validation of an OV as a therapeutic. Approval was based on therapeutic benefit, but Imlygic was not shown to improve overall survival or have an effect on visceral metastases, and the extent to which the immunotherapeutic component actually contributes to therapy is unclear. Indeed, the immune system is a double edged sword in the context of virotherapy.

For Report Sample Contact: neeraj@kuickresearch.com or +91-11-47067990

Download Report: https://www.kuickresearch.com/report--global-oncolytic-virus-therapy-market-and-pipeline-outlook-2022.php

Report Table of Contents

Prologue to Oncolytic Virus
1.1 Outline of Oncolytic Virotherapy
1.2 Trail from Genesis to Biogenetics

Primer of Virotherapy in Malignancies
2.1 Oncolytic Viruses towards Cancer
2.2 Approaches for Targeting Tumor Cells
2.2.1 Pro Apoptotic Targeting
2.2.2 Translational Targeting
2.2.3 Transcriptional Targeting
2.2.4 Transductional Targeting

Mechanism Involved in Viral Oncolysis
3.1 Viral Entry into Cancerous Cells
3.2 Efficacy Routes Followed by Oncogenic Viruses
3.3 Mechanism of Tumor Specificity
3.3.1 Defective Anti-Viral Responses
3.3.2 Receptor Targeting for Tumor Selective Intake
3.3.3 Targeting to Tumor Specific Promoters
3.3.4 Viral Gene Deletions
3.3.5 Proteolytic Processing of Virus Particles in Tumor Microenvironment

Cancer Immunotherapy by Oncolytic Viruses
4.1 Stimulation of Antitumor Immune Responses
4.2 Oncolytic Viruses as Cancer Vaccines

Varieties of Viruses Casted as Oncolytic Viruses
5.1 Oncolytic Wild Type Viruses
5.1.1 Reovirus (Respiratory Enteric Orphan Virus)
5.1.2 Vesicular Stomatitis Virus (VSV)
5.1.3 Newcastle Disease Virus (NDV)
5.1.4 Myxoma
5.2 Genetically Engineered Oncolytic Viruses
5.2.1 Adenoviruses
5.2.2 Herpes Simplex Virus
5.2.3 Vaccinia Virus

Approved Oncolytic Virus Therapeutics
6.1 Onxy-15
6.2 RIGVIR
6.3 Talimogene laherparepvec (T-VEC)
6.4 Reolysin

Potential Oncolytic Viruses for Cancers
7.1 Breast Cancer
7.2 Lung Cancer
7.3 Prostate Cancer
7.4 Melanoma
7.5 Brain Tumor
7.6 Blood Cancer

Global Oncolytic Virus Therapy Market Overview
8.1 Preface towards Oncolytic Virus Arcade
8.2 Market Aspects of Approved Oncolytic Viruses
8.3 Oncolytic Virus Clinical Pipeline Overview

Oncolytic Virus Market Dynamics
9.1 Accelerative Parameters
9.2 Major Challenges Faced by Oncolytic Virus

Future Aspects of Oncolytic Viral Therapy

Global Oncolytic Virus Clinical Pipeline by Company, Indication and Phase
11.1 Research
11.2 Preclinical
11.3 Phase-I
11.4 Phase-I/II
11.5 Phase-II
11.6 Phase-II/III
11.7 Phase-III

Marketed Oncolytic Virus Clinical Insight by Company and Indication
12.1 Talimogene Laherparepvec (IMLYGIC)
12.2 H 101 (Oncorine)

No Development Reported Oncolytic Virus Clinical Insight by Company, Indication and Phase
13.1 No Development Reported
13.2 Discontinued

Competitive Landscape
14.1 BioVex
14.2 Cell Genesys
14.3 Crusade Laboratories
14.4 Genelux Corporation
14.5 Jennerex Biotherapeutics
14.6 Lokon Pharma
14.7 Merck
14.8 MultiVir
14.9 Oncolys BioPharma
14.10 Oncolytics Biotech
14.11 Oncos Therapeutics
14.12 PsiOxus Therapeutics
14.13 Shanghai Sunway Bioteh
14.14 Takara Bio
14.15 VCN Biosciences
14.16 ViroTarg
14.17 Vyriad

Kuick Research is a market research and analytics company that provides targeted information for critical decisions at business, product and service levels. We are quick, predictive and known by the recommendations we have made in the past. Our result-oriented research methodology offers understanding of multiple issues in a short period of time and gives us the capability to keep you full with loads of practical ideas. By translating research answers into strategic insight and direction, we not only rate the success potential of your products and/or services, but also help you identify the opportunities for growth in new demographies and find ways to beat competition.

Neeraj Chawla
neeraj@kuickresearch.com
KuicK Research
Avanta Business Center 4th Floor,
Statesman House Barakhamba Road,
Connaught Place New Delhi – 110 001, India
+91-11-47067990

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