US Cancer Vaccine Market Sales Revenue Opportunity Report 2020

Escalating cancer incidences have made the investigators to come forth with therapeutics that could reduce high morbidity and mortality rates. Cancer segment has several products belonging to different categories having different pharmacological efficacy. So, it becomes imperative for investigators to develop products that have both high pharmacological and commercialization potential. Numerous cancer therapeutic is available in market but they have limited pharmacological efficacy and high unmet medical necessities prevails across the globe. Vaccination has been successfully employed to treat various infectious diseases and this idea has been extended to treat different malignancies. In past few decades, various malignancies have increased several folds in US due to which regulatory authorities are willing to accept cancer vaccines as a viable option. After hard work of several decades, investigators have been able to successfully market cancer vaccines in US market.

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"US Cancer Vaccine Market Outlook 2020"Table of Contents

1. Introduction to Cancer Vaccine

2. Cancer Vaccine Mechanism & Innovations
2.1 Idiotype Cancer Vaccine Mechanism
2.2 Cellular Cancer Vaccines Mechanism
2.3 Ganglioside Antigens based Cancer Vaccines Mechanism
2.4 Peptide Cancer Vaccine Mechanism
2.5 Tumor Host Interaction Cancer Vaccine Mechanism

3. Adjuvants Platforms for Cancer Vaccine Delivery

4. US Cancer Incidence & Prevalence
4.1 Leading Cancer Incidence
4.2 Incidence by State
4.3 Incidence by Gender
4.4 Incidence by Age Group

5. US Cancer Vaccine Market Analysis
5.1 Current Market Scenario
5.2 Cancer Vaccine Clinical Pipeline Analysis
5.3 Pricing & Reimbursement Policy

6. Cancer Vaccine with Orphan Status

7. Cancer Research Funding & Grants

8. US Cancer Vaccine Market Dynamics
8.1 Favorable Market Parameters
8.2 Market Challenges

9. US Cancer Vaccine Market Future Growth Opportunities

10. US Cancer Vaccine Clinical Pipeline by Company, Indication & Phase
10.1 Research
10.2 Preclinical
10.3 Clinical
10.4 Phase-I
10.5 Phase-I/II
10.6 Phase-II
10.7 Phase-II/III
10.8 Phase-III
10.9 Registered

11. Clinical Insight of Marketed Cancer Vaccines in US
11.1 Bladder Cancer Vaccine - ID Biomedical (PACIS®)
11.2 Bladder Cancer Vaccine - Organon Teknika (OncoTICE)
11.3 Human Papillomavirus Vaccine Quadrivalent - Merck (Gardasil®)
11.4 Human Papillomavirus Vaccine Recombinant Bivalent - GlaxoSmithKline/MedImmune
(Cervarix®)
11.5 Prostate Cancer - Dendreon Corporation (Provenge®)

12. Discontinued & Suspended Cancer Vaccine in Clinical Pipeline
12.1 No Development Reported
12.2 Discontinued
12.3 Suspended

13. FDA Regulations for Clinical Trials of Cancer Vaccines
13.1 Considerations for both Early and Late Phase Clinical Trials
13.1.1 Patient Population
13.1.2 Monitoring the Immune Response
13.1.3 Biomarkers as Evidence of Efficacy
13.1.4 Adjuvants Used To Stimulate Immune Response
13.1.5 Multi-Antigen Vaccines
13.1.6 Disease Progression/Recurrence Immediately or Shortly After the Initial Administration of Cancer Vaccines
13.1.7 Concomitant & Subsequent Therapies
13.2 Considerations for Early Phase Clinical Trials
13.2.1 Starting Dose & Dosing Schedule
13.2.2 Booster & Maintenance Therapy
13.2.3 Dose Escalation
13.2.4 Single-Arm versus Randomized Phase 2 Trials In Early Development
13.3 Considerations for Late Phase Clinical Trials
13.3.1 Safety Profile from Early Phase Clinical Trials
13.3.2 Endpoints
13.3.3 Statistical Issues
13.3.4 Control Issues
13.3.5 Delayed Vaccine Effect
13.3.6 Autologous Vaccine Trials
13.3.7 Accelerated Approval Regulations

14. Competitive Landscape
14.1 Aduro BioTech
14.2 Advaxis
14.3 Antigen Express
14.4 Argos Therapeutics
14.5 Bavarian Nordic
14.6 Celldex Therapeutics
14.7 Cosmo Pharmaceuticals
14.8 Dendreon Corporation
14.9 Galena Biopharma
14.10 Generex Biotechnology
14.11 Gradalis
14.12 GSK
14.13 Merck
14.14 NewLink Genetics
14.15 Oxford BioMedica

Figure 1-1: Categorization & Function of Cancer Vaccines
Figure 2-1: Classification of Different Types of Cancer vaccines
Figure 5-1: US Cancer Vaccine Market (US$ Billion), 2014-2020
Figure 5-2: US Share in Global Cancer Vaccines Market (%), 2014 & 2020
Figure 5-3: US Vaccine Markey by Therapeutic & Prophylactic Vaccines, 2014 & 2020
Figure 5-4: US Prophylactic Cancer Vaccines Market, (US$ Billion), 2014-2020
Figure 5-5: US Therapeutic Cancer Vaccines Market, (US$ Billion), 2014-2020
Figure 5-6: US Cancer Vaccine Pipeline by Phase (%), 2015
Figure 5-7: US Cancer Vaccine Pipeline by Phase (Number), 2015
Figure 5-8: No Development Reported US Cancer Vaccine Pipeline by Phase (%), 2015
Figure 5-9: No Development Reported US Cancer Vaccine Pipeline by Phase (Number), 2015
Figure 5-10: Discontinued US Cancer Vaccine Pipeline by Phase (%), 2015
Figure 5-11: Discontinued US Cancer Vaccine Pipeline by Phase (Number), 2015
Figure 5-12: Suspended US Cancer Vaccine Pipeline by Phase (%), 2015
Figure 5-13: Suspended US Cancer Vaccine Pipeline by Phase (Number), 2015
Figure 14-1: Advaxis Clinical Pipeline
Figure 14-2: Argos Therapeutics Clinical Pipeline
Figure 14-3: Cosmo Pharmaceuticals Clinical Pipeline
Figure 14-4: Gradalis Clinical Pipeline
Figure 14-5: NewLink Genetics Clinical Pipeline

Table 4-1: Estimated Number of New Cases for Selected Cancers by State, 2015
Table 4-2: Estimated Number of Deaths for Selected Cancers by State, 2015
Table 4-3: Estimated Number of New Cancer Cases and Deaths by Gender, 2015
Table 4-4: Estimated New Cancer Cases by Age (Years), 2015
Table 4-5: Estimated Cancer Deaths by Age (Years), 2015
Table 6-1: US Orphan Designated Cancer Vaccines
Table 7-1: Spending on Cancer Research (US$ Million), 2010-2012
Table 7-2: Grants for Cancer Research (US$), 2013
Table 7-3: Grants for Cancer Research by States (US$), 2013
Table 7-4: Cancer Funding by Area of Research (US$)
Table 14-1: Aduro BioTech Cancer Vaccine Pipeline
Table 14-2: Aduro BioTech Cancer Immunotherapies
Table 14-3: Antigen Express Cancer Vaccine Pipeline
Table 14-4: Bavarian Nordic Cancer Vaccine Pipeline
Table 14-5: Celldex Therapeutics Cancer Vaccine Pipeline
Table 14-6: Dendreon Corporation Cancer Vaccine Pipeline
Table 14-7: Galena Biopharma Cancer Vaccine Pipeline
Table 14-8: GSK Cancer Vaccine Pipeline
Table 14-9: Merck Cancer Vaccine Pipeline
Table 14-10: Oxford BioMedica Cancer Vaccine Pipeline

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