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Synovial Sarcoma Exhibits Emerging Pipeline with 22 Drug Candidates
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Insights on pipeline segments
As per the findings of the research, around 44.0% of drug candidates for the treatment of Synovial sarcoma pipeline are being developed to be administered by intravenous route, 28.0% by oral route, 17.0% are undisclosed and 11.0% are to be administered by other routes which includes intradermal and intramuscular.
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New innovating technologies offer development of promising drugs
Many technologies such as REOLYSIN technology, ZVex and GLAAS technology, Laser Micro-beam Microdissection are being developed that can bring the innovative treatment, which can control the progression of Synovial sarcoma. ZVex and GLAAS are complementary discovery platforms designed to activate and expand the immune system’s natural ability to create tumour-specific cytotoxic T cells (CTLs) in vivo. ZVex and GLAAS have been productive and generated all of Immune Design’s oncology product candidates. In addition to oncology, these novel technology platforms hold promising results for applications in the fields of infectious and allergic diseases, and have also been the source of several partnered programs.
Major companies collaborate for the development of Synovial sarcoma Pipeline
The research also found that various companies have collaborated for the development of Synovial sarcoma pipeline. In February 2014, Pfizer Inc. (Pfizer) and Merck & Co., Inc. (Merck) agreed to explore the therapeutic potential of Merck’s investigational anti-PD-1 therapy, MK-3475, in combination with two of the Pfizer’s oncology assets. A Phase I/II clinical study was undertaken to evaluate the safety and anti-cancer efficacy of MK-3475 combined with Pfizer’s axitinib (INLYTA) in renal cell carcinoma (RCC). A separate Phase I study was also done to evaluate the safety and tolerability of the combination of MK-3475 and PF-05082566 (PF-2566), Pfizer’s investigational, fully humanized monoclonal antibody (mAb) that stimulates signaling through 4-1BB (CD-137), a protein involved in regulation of immune cell proliferation and survival.
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Many companies are developing Synovial sarcoma drug candidates in different phases. Adaptimmune Therapeutics plc, Epizyme Inc., Advenchen Laboratories LLC, F. Hoffmann-La Roche AG, Cue Biopharma, Inc., Bayer AG, Merck Sharp & Dohme Corp., Pfizer Inc., Immune Design Inc. and various other companies have their Synovial sarcoma drug candidates in different stages of development.
Other key players developing drugs for Synovial sarcoma include Takara Bio Inc., Oncolytics Biotech Inc., Accuronix Therapeutics, Inc., Cue Biopharma, Inc., NewVac LLC, Stemsynergy Therapeutics, Inc. and Immunocore Limited.
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