Anisindione 2017 Global Market Key Players – Aimpow, Toronto Research Chemicals, Santacruz Biotechnology, Schering Plough, Bayer– Analysis and Forecast to 2022

What is Anisindione and what are its Contraindications?

Anisindione (brand name Miradon) is a synthetic anticoagulant and an indanedione derivative. It prevents the formation of anticoagulant proteins C and S, as well as active procoagulation factors II, VII, IX, and X in the liver by reducing the vitamin K. This results in inhibition of gamma-carboxylation of precursor protein glutamic acid to gamma-carboxyglutamic acid. The resultant effect of all these reactions in the body is prolongation of blood clotting time and reduced activity of clotting factors. Anisindione is used for treatment of atrial fibrillation with embolization, the prophylaxis and treatment of venous thrombosis, the prophylaxis and treatment of pulmonary embolism, disseminated intravascular coagulation and treatment of coronary occlusion.

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Molecular Formula of Anisindione is C16H12O3
synonyms-2-(4-methoxyphenyl)-1H-indene-1,3(2H)-dione,2-para-Anisyl-1,3-indandione,2-(p-Methoxyphenyl)indane-1,3-dione, Unidone, Anisindionum

Methods of manufacturing

Anisindione is prepared from anisaldehyde and phthalide in sodium alcoholate. The alternate method of fabricating this compound is from 1-p-methoxybenzalphthalide and sodium methoxide.

Adverse reactions

Apart from hemorrhagic disorders, other adverse reactions include nausea and vomiting, abdominal cramps, diarrhea, pyrexia, anorexia, dermatitis or exfoliative dermatitis, sore throat, jaundice, hepatitis, anemia , liver damage, dermatitis, headache, urticaria, erythema and necrosis of the skin and other tissues alopecia, leukopenia, myeloid immaturity, paralysis of accommodation of eyes, sore mouth or mouth ulcers, priapism, albuminuria, eosinophilia, red cell aplasia, steatorrhearenal tubular necrosis, blurred vision, anuria, thrombo-cytopenia purple toes, atypical mononuclear cells, leukocytosis, leukocyte agglutinins, agranulocytosis, cutaneous gangrene and Phenprocoumon-induced delayed callus formation after bone fracture.

Contraindications

• History or tendency of bleeding, hemophilia, purpura, polycythemia vera, leukemia, cerebral hemorrhage which has taken place recently, ulcers in the the gastrointestinal tract, ulcerative colitis, wounds due to trauma or wounds from surgery
• recent or planned eye surgery, brain surgery, or surgery of spinal cord or prostatectomy
• Patients with continuous tube drainage of small gut
• Visceral carcinoma, severe kidney disease, severe liver disease, pericarditis, subacute bacterial endocarditis, diverticulitis, polyarthritis or aneurysm.
• malignant severe or hypertension, threatened abortion, preeclampsia or eclampsia,
• Malnutrition, emaciation, and vitamin K or C deficiencies.
• Pregnancy - Anisindione is not to be used during pregnancy as the
drug travels across the placental barrier and can cause damage to fetus.

Hemorrhage of neonate or Fetus and intrauterine fetal death have happened even when the level of prothrombin in mother were within the accepted range. Other disorders like hypoplasia of nasal structures, Conradi-Hunermann syndrome may occur. Other alternatives like heparin, which does not cross the placenta, need to be used in cases of pregnancy.

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In this report, the global Anisindione market is valued at USD XX million in 2016 and is expected to reach USD XX million by the end of 2022, growing at a CAGR of XX% between 2016 and 2022.

Geographically, this report split global into several key Regions, with sales (K Pcs), revenue (Million USD), market share and growth rate of Anisindione for these regions, from 2012 to 2022 (forecast), covering
• United States
• China
• Europe
• Japan
• Southeast Asia
• India

Global Anisindione market competition by top manufacturers/players, with Anisindione sales volume, Price (USD/Pcs), revenue (Million USD) and market share for each manufacturer/player; the top players including
• Aimpow
• Toronto Research Chemicals
• Santacruz Biotechnology
• Schering Plough
• Bayer
...

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Table of Contents

Global Anisindione Sales Market Report 2017
1 Anisindione Market Overview
1.1 Product Overview and Scope of Anisindione
1.2 Classification of Anisindione by Product Category
1.2.1 Global Anisindione Market Size (Sales) Comparison by Type (2012-2022)
1.2.2 Global Anisindione Market Size (Sales) Market Share by Type (Product Category) in 2016
1.2.3 Oral Drugs
1.2.4 Injectable Drugs
1.3 Global Anisindione Market by Application/End Users
1.3.1 Global Anisindione Sales (Volume) and Market Share Comparison by Application (2012-2022)
1.3.2 Anticoagulant
1.3.3 Protein Hydrolysis
1.3.4 Others
1.4 Global Anisindione Market by Region
1.4.1 Global Anisindione Market Size (Value) Comparison by Region (2012-2022)
1.4.2 United States Anisindione Status and Prospect (2012-2022)
1.4.3 China Anisindione Status and Prospect (2012-2022)
1.4.4 Europe Anisindione Status and Prospect (2012-2022)
1.4.5 Japan Anisindione Status and Prospect (2012-2022)
1.4.6 Southeast Asia Anisindione Status and Prospect (2012-2022)
1.4.7 India Anisindione Status and Prospect (2012-2022)
1.5 Global Market Size (Value and Volume) of Anisindione (2012-2022)
1.5.1 Global Anisindione Sales and Growth Rate (2012-2022)
1.5.2 Global Anisindione Revenue and Growth Rate (2012-2022)
10 Anisindione Maufacturing Cost Analysis
10.1 Anisindione Key Raw Materials Analysis
10.1.1 Key Raw Materials
10.1.2 Price Trend of Key Raw Materials
10.1.3 Key Suppliers of Raw Materials
10.1.4 Market Concentration Rate of Raw Materials
10.2 Proportion of Manufacturing Cost Structure
10.2.1 Raw Materials
10.2.2 Labor Cost
10.2.3 Manufacturing Process Analysis of Anisindione
10.3 Manufacturing Process Analysis of Anisindione

11 Industrial Chain, Sourcing Strategy and Downstream Buyers
11.1 Anisindione Industrial Chain Analysis
11.2 Upstream Raw Materials Sourcing
11.3 Raw Materials Sources of Anisindione Major Manufacturers in 2016
11.4 Downstream Buyers

12 Marketing Strategy Analysis, Distributors/Traders
12.1 Marketing Channel
12.1.1 Direct Marketing
12.1.2 Indirect Marketing
12.1.3 Marketing Channel Development Trend
12.2 Market Positioning
12.2.1 Pricing Strategy
12.2.2 Brand Strategy

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