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Hemophilia Therapeutics Pipeline Analysis, 2017 - Clinical Trials & Results, Patent, Collaboration, and Other Developments
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Most of the large pharma companies are spending in research and development for treatment of haemophilia, which are in clinical trials. Pfizer, Inc. is developing a gene therapy in collaboration with Spark Therapeutics, Inc., through SPK-FIX program for treatment of haemophilia, as a potential onetime therapy. SPK-9001 is a bio-engineered adeno-associated virus (AAV) capsid expressing a codon-optimized, high-activity human factor IX variant, which was advanced using Spark's proprietary technology. Chugai Pharmaceutical is developing a compound in collaboration with F. Hoffmann-La Roche AG, Emicizumab, which is considered as a Breakthrough Therapy by the US Food and Drug Administration. LFB USA, Inc. is introducing a biological, wich is recombinant Coagulation FVIIa for the treatment of haemophilia. Coagulation FVIIa is currently in Phase III clinical development stage. Alnylam Pharmaceuticals Inc. is developing a drug for the treatment of haemophilia, ALN-AT3SC, which lowers the level of plasma antithrombin. ALN-AT3SC drug led to restoration of homeostasis in people with haemophilia. OPKO Biologics Ltd. Is developing a drug MOD-5014, whih is a long-acting recombinant FVIIa for the treatment of hemophiia A or B. Octapharma AG is developing a compound fr the treatment of haemophilia, Wilate, which is stable, double virus inactivated, stable, highly purified concentrate of freeze-dried, active von Willebrand factor (VWF) and FVIII. Wilate is currently in Phase III clinical development. Novo Nordisk A/S is estimating a homeostatic effect of turoctocog alfa pegol, which is currently in Phase III. Bayer AG is developing a compound BAY1093884. BAY1093884 is an anti-TFPI antibody which is currently in Phase I. Shire Plc is developing a compound SHP656, which is currently in Phase I clinical development.
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Some of the key players having a pipeline of hemophilia therapeutics include Shire Plc, Biogen, Pfizer Inc., Novo Nordisk A/S, CSL Behring, F. Hoffmann-La Roche Ltd., Bayer AG, Biotest AG, Kedrion Biopharma Inc., and Octapharma AG.
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