B-Cell Non-Hodgkin Lymphoma Pipeline Expands as 75+ Companies Driving Innovation in the Therapeutics | DelveInsight

DelveInsight's "B-Cell Non-Hodgkin Lymphoma Pipeline Insight 2026" report provides comprehensive insights about 75+ companies and 80+ pipeline drugs in B-Cell Non-Hodgkin Lymphoma pipeline landscape. It covers the B-Cell Non-Hodgkin Lymphoma pipeline drug profiles, including clinical and nonclinical stage products. It also covers the B-Cell Non-Hodgkin Lymphoma therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive B-cell non-Hodgkin Lymphoma pipeline products in this space.

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Key Takeaways from the B-Cell Non-Hodgkin Lymphoma Pipeline Report
• In August 2026, Johnson & Johnson continued clinical development of JNJ-95566692 and JNJ-87801493 in relapsed/refractory B-cell non-Hodgkin lymphoid malignancies, including multiple large B-cell lymphoma subtypes. The Phase I study is evaluating these investigational approaches in patients with limited approved treatment options.
• In August 2026, AstraZeneca's AZD0486 remained under clinical evaluation in B-cell non-Hodgkin lymphoma, including diffuse large B-cell lymphoma, high-grade B-cell lymphoma, and follicular lymphoma. The ongoing study includes relapsed/refractory cohorts and is evaluating the investigational therapy in patients who have received multiple prior treatments.
• DelveInsight's B-Cell Non-Hodgkin Lymphoma pipeline report depicts a robust space with 75+ active players working to develop 80+ pipeline therapies for B-Cell Non-Hodgkin Lymphoma treatment.
• The leading B-Cell Non-Hodgkin Lymphoma Companies such as Xencor, MEI Pharma, Celldex Therapeutics, TG Therapeutics, Shanghai Unicar-Therapy Bio-medicine Technology, Chia Tai Tianqing Pharmaceutical Group, Mustang Bio, Novartis, Loxo Oncology, Genmab, Nkarta, Nurix Therapeutics, Prelude Therapeutics and others.
• Promising B-Cell Non-Hodgkin Lymphoma Therapies such as Bendamustine hydrochloride injection, ibrutinib, PF-3512676, Cyclophosphamide, Mitoxantrone, Vincristine, Velcade, Temsirolimus, Glofitamab, Atezolizumab, Obinutuzumab, and others.

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B-Cell Non-Hodgkin Lymphoma Overview
B-cell non-Hodgkin lymphoma (NHL) is a type of cancer that originates from abnormal B lymphocytes, a type of white blood cell that is part of the immune system. It is the most common form of NHL, accounting for over 85% of cases. B-cell NHL can be further classified into various subtypes based on the specific characteristics of the cancer cells, such as their appearance under a microscope, the presence of certain proteins on their surface, and their genetic features. The most prevalent subtypes include diffuse large B-cell lymphoma (DLBCL), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), and Burkitt lymphoma. B-cell NHL can develop in lymph nodes or other lymphoid tissues, and it may also affect extralymphatic organs such as the gastrointestinal tract. B-cell non-Hodgkin lymphoma presents with various symptoms that can include painless swelling of lymph nodes, unexplained fever, drenching night sweats, persistent fatigue, weight loss, itchy skin, and pain in the chest, abdomen, or bones. These symptoms, when occurring together, are referred to as B symptoms and are significant for prognosis and staging of the disease.

B-Cell Non-Hodgkin Lymphoma Emerging Drugs Profile

• Valemetostat: Daiichi Sankyo
Valemetostat is an investigational and potential first-in-class EZH1/2 dual inhibitor in phase II clinical development for hematologic cancers including acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), and Non-Hodgkin lymphoma (NHL), including adult T-cell leukemia/lymphoma (ATL/L), peripheral T-cell lymphoma (PTCL), and B-cell lymphomas.

• MB-106: Mustang Bio
MB-106 is a CD20-targeted autologous CAR T cell therapy developed for the treatment of B-cell non-Hodgkin lymphomas (B-NHLs) and chronic lymphocytic leukemia (CLL). This therapy, optimized as a third-generation CAR derived from a fully human antibody, has shown promising results in clinical trials. Currently, the drug is in Phase I/II stage of its clinical trial for the treatment of B-cell non-Hodgkin lymphoma.

• CB-010: Caribou Biosciences
CB-010, our lead clinical-stage program, is an allogeneic anti-CD19 CAR-T cell therapy designed for patients with relapsed or refractory B cell non-Hodgkin lymphoma (r/r B-NHL). It is the first known allogeneic CAR-T cell therapy in clinical trials to incorporate a PD-1 knockout, utilizing a genome-editing strategy aimed at enhancing antitumor activity by preventing premature CAR-T cell exhaustion. The manufacturing process for CB-010 involves three key edits using Cas9 chRDNA guides: knocking out the TRAC gene to remove the T cell receptor, site-specific insertion of an anti-CD19 CAR into the TRAC gene, and knocking out PD-1. Currently, the drug is in Phase I stage of its clinical trial for the treatment of r/r B-NHL.

• LP-284: Lantern Pharma
LP-284 is an innovative small molecule drug developed by Lantern Pharma, designed to selectively target cancer cells with mutations in DNA damage repair pathways. Its development is accelerated by AI and biological modeling through Lantern's RADR platform. The FDA has granted orphan drug designation to LP-284 for treating high-grade B-cell lymphoma (HGBL) with MYC and BCL2 rearrangements. Currently, the drug is in Phase I stage of its clinical trial.

The B-Cell Non-Hodgkin Lymphoma pipeline report provides insights into
• The report provides detailed insights about companies that are developing therapies for the treatment of B-Cell Non-Hodgkin Lymphoma with aggregate therapies developed by each company for the same.
• It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for B-Cell Non-Hodgkin Lymphoma Treatment.
• B-Cell Non-Hodgkin Lymphoma Companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
• B-Cell Non-Hodgkin Lymphoma Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
• Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the B-Cell Non-Hodgkin Lymphoma market.

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B-Cell Non-Hodgkin Lymphoma Companies
Xencor, MEI Pharma, Celldex Therapeutics, TG Therapeutics, Shanghai Unicar-Therapy Bio-medicine Technology, Chia Tai Tianqing Pharmaceutical Group, Mustang Bio, Novartis, Loxo Oncology, Genmab, Nkarta, Nurix Therapeutics, Prelude Therapeutics and others.

B-Cell Non-Hodgkin Lymphoma pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
• Oral
• Intravenous
• Subcutaneous
• Parenteral
• Topical

B-Cell Non-Hodgkin Lymphoma Products have been categorized under various Molecule types such as
• Recombinant fusion proteins
• Small molecule
• Monoclonal antibody
• Peptide
• Polymer
• Gene therapy

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Scope of the B-Cell Non-Hodgkin Lymphoma Pipeline Report
• Coverage- Global
• B-Cell Non-Hodgkin Lymphoma Companies- Xencor, MEI Pharma, Celldex Therapeutics, TG Therapeutics, Shanghai Unicar-Therapy Bio-medicine Technology, Chia Tai Tianqing Pharmaceutical Group, Mustang Bio, Novartis, Loxo Oncology, Genmab, Nkarta, Nurix Therapeutics, Prelude Therapeutics and others.
• Promising B-Cell Non-Hodgkin Lymphoma Therapies- Bendamustine hydrochloride injection, ibrutinib, PF-3512676, Cyclophosphamide, Mitoxantrone, Vincristine, Velcade, Temsirolimus, Glofitamab, Atezolizumab, Obinutuzumab, and others.
• B-Cell Non-Hodgkin Lymphoma Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
• B-Cell Non-Hodgkin Lymphoma Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III

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Table of Content
1. Introduction
2. Executive Summary
3. B-Cell Non-Hodgkin Lymphoma: Overview
4. Pipeline Therapeutics
5. Therapeutic Assessment
6. B-Cell Non-Hodgkin Lymphoma- DelveInsight's Analytical Perspective
7. Late Stage Products (Phase III)
8. Drug name: Company name
9. Drug profiles in the detailed report.....
10. Mid Stage Products (Phase II)
11. Valemetostat: Daiichi Sankyo
12. Drug profiles in the detailed report.....
13. Early Stage Products (Phase I)
14. CB-010: Caribou Biosciences
15. Drug profiles in the detailed report.....
16. Preclinical and Discovery Stage Products
17. Drug name: Company name
18. Drug profiles in the detailed report.....
19. Inactive Products
20. B-Cell Non-Hodgkin Lymphoma Key Companies
21. B-Cell Non-Hodgkin Lymphoma Key Products
22. B-Cell Non-Hodgkin Lymphoma- Unmet Needs
23. B-Cell Non-Hodgkin Lymphoma- Market Drivers and Barriers
24. B-Cell Non-Hodgkin Lymphoma- Future Perspectives and Conclusion
25. B-Cell Non-Hodgkin Lymphoma Analyst Views
26. B-Cell Non-Hodgkin Lymphoma Key Companies
27. Appendix

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