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Hepcidin antagonist, Pipeline Analysis, 2016 by P&S Market Research

03-07-2017 01:51 PM CET | Health & Medicine

Press release from: P&S Market Research- Pharmaceuticals

Hepcidin antagonist, Pipeline Analysis, 2016 by P&S Market

Hepcidin is a small peptide which acts as iron regulatory hormone. The name ‘hepcidin’ is taken from the place of synthesis in hepatocytes (hep), whereas cidin denotes its antimicrobial activity. Liver is the key organ that secrete hepcidin and regulates iron hormone. Hepcidin was initially observed in human urine sample and in human blood ultrafiltrate as a small bactericidal peptide (defensin and cathelicidin) and now it is known as liver–expressed antimicrobial peptide. Hepcidin is encoded by HAMP, 19q13 gene, which is expressed in the liver, heart, lungs, brain, spinal cord, intestine, macrophages and several other organs. The mode of action of hepcidin activity depends on the interaction between hepcidin and ferroportin. Ferroportin is expressed on the surface of reticulo-endothelial macrophages, hepatocytes, duodenal enterocytes and placenta cells. It is the only known mammalian cellular iron exporter. Binding of Hepcidin with ferroportin causes its internalization and degradation in endo lysosomes, which in turn blocks the iron transport through ferroportin.

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The hepcidin antagonist pipeline has more than 10 drugs. In pipeline analysis, drugs are analyzed on the basis of route of administration and molecule type. The pipeline is also analyzed on the basis of monotherapy and combination therapy, and different clinical phases including Phase III, Phase II, Phase I and Pre-clinical stage.

Phase III

Phase III clinical trial known for the comparison of new treatments with the standard treatment in which the safety, efficacy and side effects of new intervention is compared with the already existing treatment. The Phase III clinical trial takes around 2-3 years to complete and the total number of participants vary from 100-1,000. In Hepcidin antagonist, there are 3 drugs in phase III clinical trial. For instance, Luspatercept, a phase III drug candidate of Celgene Corporation is being developed in collaboration with Acceleron Pharma, Inc., for the treatment of anemia with myelodysplastic syndromes and anemia associated with beta thalassaemia.

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Phase II

NOX-H94 is a phase II drug candidate of NOXXON Pharma N.V. The drug candidate is an anti-hepcidin single-stranded structured L-RNA oligonucleotide conjugated to 40kDa polyethylene glycol. Phase II clinical trial is the second phase that answer safety, efficacy and dosing of the new intervention. It takes around 2 years to complete and between 100 – 120 patients participate in the Phase II trial.

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Phase I

PRS 080, a phase I/II drug candidate is under development by Pieris Pharmaceuticals, Inc. for the treatment of anemia. The drug candidate is an hepcidin antagonist, which can restore iron utilization and erythropoiesis. The company mentioned that the compound has successfully shown a favorable safety profile in healthy volunteers and is expected to complete a multi-dose trial by mid of 2017. In Phase I clinical trial, safety of the new intervention is determined. The trial takes around 1-2 years to complete and the total number of volunteers participating in the trial vary between 15 – 30.

About P&S Market Research

P&S Market Research is a market research company, which offers market research and consulting services for various geographies around the globe. We provide market research reports, industry forecasting reports, business intelligence, and research based consulting services across different industry/business verticals.

As one of the top growing market research agency, we’re keen upon providing market landscape and accurate forecasting. Our analysts and consultants are proficient with business intelligence and market analysis, through their interaction with leading companies of the concerned domain. We help our clients with B2B market research and assist them in identifying various windows of opportunity, and framing informed and customized business expansion strategies in different regions.

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