Voltage Dependent Gating a Revolution in Biotechnology

Regardless of the source of the crude protein solution (whether from the lysis of 'inclusion bodies', secretory precision fermentation or the lysis of plant proteins), the system separates a target protein from a heterogeneous mixture of charged molecules, such as proteins, and molecules with a neutral charge or completely without.

While classical methods force you to clean the broth to find the protein, the system forces to cleanly exit the broth. It transforms downstream processing from a costly, multistage batch bottleneck into an elegant, continuous, and highly automated separation.

Forget about the laborious, cumbersome purification using chromatographic methods, which are time-consuming and, until now, have only been possible on a batch basis. They are the antithesis of this technology, which also allows for automated operation, is built on a modular system of reactors, and offers easy scalability.
This technology has not been published in any science papers or patents and should be regarded as a real innovation. A small system in a stacked configuration contains 5 reactors of 200 litres each in sum 1 m3/h throughput.

1. Active Anti-Fouling via Pulsed-Current Gating
Continuous direct current (DC) leads to rapid concentration polarization, resulting in heavy bio-fouling on membrane surfaces.
Mechanism: The electric field is pulsed at high frequencies in the millisecond range (e.g.).
Benefit: During the OFF phase, the polarization boundary layer collapses. Cellular debris and foulants diffuse back into the bulk solution before irreversible fouling can occur. High permeate flux is maintained without chemical Clean-in-Place (CIP) interruptions.
2. Isothermal Processing with Minimal Shear Stress
Mechanism: Separation is driven by an electrical potential gradient (∇V) rather than high hydraulic trans-membrane pressure (TMP). Integrated cooling loops continuously absorb Joule heating, while millisecond pulse pauses prevent local thermal spikes.
Benefit: Target proteins experience virtually zero mechanical shear force and remain within a tight thermal window, preserving 100% native conformation and biological activity.
3. Reduced System Resistance & Streamlined Integration
Mechanism: Using a single CEM and two functional chambers minimizes inter-electrode distance and eliminates secondary membrane boundaries.
Benefit: Significantly lower voltage requirements, reduced operational power draw, simpler skid hydraulics, and lower capital expenditure compared to multi-chamber or chromatography-based alternatives.

The system is modular and easily scalable.

For example, the costs (APEX/OPEX) amount to only around 50 per cent of the production costs for lactoferrin derived from whey. In fact, any company that produces lactoferrin should switch over immediately, as the payback period is less than one year and the ROI extremely high.

Bioway Consulting SL
Calle Tirant Lo Blanc 4 , office 19
ES-03750 Pedreguer / Alicante - Spain
Mr. Norbert Pautz (Presscontact)
mail: contact@biowayconsulting.com
phone: 0034965030786
www.biowayconsulting.com

Bioway has been in existence for almost 40 years and was founded as a sole proprietorship in Germany. A limited liability company was established in Switzerland with a subsidiary in Germany and later as a private limited on shares in Cyprus. Now since November 2024 Bioway Consulting SL is incorporated
Bioway deals with electrolysis-based wastewater treatment technologies, incorporating complementary technologies such as membrane filtration. Furthermore, a system for air purification / disinfection was developed to inactivate infectious biological particles such as viruses and bacteria.
Bioway works as a consultant mainly in D, A, CH - German-speaking countries, whereby new technologies are further developed and sold on the market in co-operation with system manufacturers.
The main task is to advise customers, solve problems, implement technology to solve tasks and sell systems / equipment for the purification of liquids (e.g. cooling lubricants) and industrial waste water. R & D take place in an own laboratory is Spain. New project again is protein extraction with electrolytic methods.

This release was published on openPR.