Brutons Tyrosine Kinase Inhibitors Treatment Pipeline Shows Strong Momentum as 30+ Pharma Companies in the Race | DelveInsight

DelveInsight's "Brutons Tyrosine Kinase Inhibitors Pipeline Insight 2025" report provides comprehensive insights about 30+ companies and 30+ pipeline drugs in the Brutons Tyrosine Kinase Inhibitors pipeline landscape. It covers the Brutons Tyrosine Kinase Inhibitors pipeline drug profiles, including clinical and nonclinical stage products. It also covers the Brutons Tyrosine Kinase Inhibitors pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

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Key Takeaways from the Brutons Tyrosine Kinase Inhibitors Pipeline Report

* On February 02, 2026, Guangzhou Lupeng Pharmaceutical Company Ltd announced a Phase III Clinical Study Comparing Rocbrutinib Monotherapy Versus Investigator's Choice of BTK Inhibitors in Patients With Relapsed or Refractory Mantle Cell Lymphoma (MCL). A Phase 3, randomized, open-label study comparing Rocbrutinib versus investigator's choice of BTK inhibitor (ibrutinib, acalabrutinib, zanubrutinib, or orelabrutinib) in patients with MCL who have received at least one prior line of therapy and are naive to BTK inhibitor treatment (except for intolerance).
* On January 22, 2026- BeOne Medicines conducted a study is to investigate the efficacy and safety of BGB-16673 compared with investigator's choice (idelalisib plus rituximab [for CLL only] or bendamustine plus rituximab or venetoclax plus rituximab retreatment) in participants with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) previously exposed to both BTK inhibitors (BTKi) and BCL2 inhibitors (BCL2i).
* On January 21, 2026, Inhye Ahn initiated a phase 2 study of pirtobrutinib with obinutuzumab for participants with CLL or SLL. Eligible participants will receive 6 cycles of pirtobrutinib alone followed by an additional 6 cycles of pirtobrutinib-obinutuzumab combination therapy. All participants will stop treatment after 12 cycles in total (approximately 1 year).
* DelveInsight's Brutons Tyrosine Kinase Inhibitors Pipeline report depicts a robust space with 30+ active players working to develop 30+ pipeline therapies for Brutons Tyrosine Kinase Inhibitors treatment.
* The leading Brutons Tyrosine Kinase Inhibitors Companies, such as InnoCare Pharma, BeiGene, Principia Biopharma, Carna Biosciences, Loxo Oncology, Aptose Biosciences, Biogen and others.
* Promising Brutons Tyrosine Kinase Inhibitors Therapies such as BGB-3111, Ibrutinib, BGB-16673, Bendamustine, Rituximab, Idelalisib , and others.

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The Brutons Tyrosine Kinase Inhibitors Pipeline Report provides a disease overview, pipeline scenario, and therapeutic assessment of the key pipeline therapies in this domain. The Brutons Tyrosine Kinase Inhibitors Pipeline Report also highlights the unmet needs with respect to the Brutons Tyrosine Kinase Inhibitors.

Brutons Tyrosine Kinase Inhibitors Overview

Bruton's Tyrosine Kinase (BTK) inhibitors are a class of drugs that block the activity of the BTK enzyme, which plays a key role in the survival, proliferation, and signaling of B-cells in the immune system. By inhibiting BTK, these drugs disrupt abnormal B-cell signaling, making them highly valuable in treating B-cell-driven cancers (such as certain leukemias and lymphomas) and autoimmune diseases. They are designed to prevent disease progression by stopping cancerous or overactive B-cells from growing, communicating, and avoiding cell death.

Brutons Tyrosine Kinase Inhibitors Emerging Drugs Profile

* Zanubrutinib: BeiGene

Zanubrutinib (BGB-3111), a small molecule inhibitor of Bruton's tyrosine kinase, or BTK, that is currently being evaluated in a broad late-stage clinical trials program globally, including in China, as a potential monotherapy and in combination with other therapies to treat various B cell malignancies. It is approved for the treatment of mantle cell lymphoma, chronic lymphocytic leukemia or small lymphocytic lymphoma and Waldenstrom's macroglobulinemia. In May 2021, BeiGene announced that the U.S. Food and Drug Administration (FDA) has accepted a supplemental new drug application (sNDA) for BRUKINSA (zanubrutinib) for the treatment of adult patients with marginal zone lymphoma (MZL) who have received at least one prior anti-CD20-based therapy and granted priority review.

* Rilzabrutinib: Principia Biopharma

Rilzabrutinib (formerly known as PRN1008) is a BTK inhibitor, oral, first in class, wholly owned by Principia Biopharma is currently being evaluated in three different disease indications. It is currently in Phase III for Pemphigus, Immune Thrombocytopenia (ITP) and Phase II for autoimmune diseases like IgG4-Related Disease. Orphan drug designation is received from the United States Food and Drug Administration for rilzabrutinib for the treatment of pemphigus vulgaris and from the European Commission for the treatment of pemphigus (pemphigus vulgaris and pemphigus foliaceus).

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The Brutons Tyrosine Kinase Inhibitors Pipeline report provides insights into:-

* The report provides detailed insights about companies that are developing therapies for the treatment of Brutons Tyrosine Kinase Inhibitors with aggregate therapies developed by each company for the same.
* It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Brutons Tyrosine Kinase Inhibitors Treatment.
* Brutons Tyrosine Kinase Inhibitors Companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
* Brutons Tyrosine Kinase Inhibitors Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
* Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Brutons Tyrosine Kinase Inhibitors market.

Brutons Tyrosine Kinase Inhibitors Companies

InnoCare Pharma, BeiGene, Principia Biopharma, Carna Biosciences, Loxo Oncology, Aptose Biosciences, Biogen and others.

Brutons Tyrosine Kinase Inhibitors pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

* Oral
* Parenteral
* Intravenous
* Subcutaneous
* Topical.
* Molecule Type

Brutons Tyrosine Kinase Inhibitors Products have been categorized under various Molecule types such as

* Monoclonal Antibody
* Peptides
* Polymer
* Small molecule
* Gene therapy
* Product Type

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Scope of the Brutons Tyrosine Kinase Inhibitors Pipeline Report

* Coverage- Global
* Brutons Tyrosine Kinase Inhibitors Companies- InnoCare Pharma, BeiGene, Principia Biopharma, Carna Biosciences, Loxo Oncology, Aptose Biosciences, Biogen and others.
* Brutons Tyrosine Kinase Inhibitors Therapies- BGB-3111, Ibrutinib, BGB-16673, Bendamustine, Rituximab, Idelalisib , and others.
* Brutons Tyrosine Kinase Inhibitors Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
* Brutons Tyrosine Kinase Inhibitors Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III

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Table of Contents

* Introduction
* Executive Summary
* Brutons Tyrosine Kinase (BTK) Inhibitors: Overview
* Pipeline Therapeutics
* Therapeutic Assessment
* Late Stage Products (Phase III)
* Rilzabrutinib: Principia Biopharma
* Mid Stage Products (Phase II)
* Orelabrutinib: InnoCare Pharma
* Early stage products (Phase I)
* PRN473: Principia Biopharma
* Preclinical stage products
* Inactive Products
* Brutons Tyrosine Kinase (BTK) Inhibitors Key Companies
* Brutons Tyrosine Kinase (BTK) Inhibitors Key Products
* Brutons Tyrosine Kinase (BTK) Inhibitors- Unmet Needs
* Brutons Tyrosine Kinase (BTK) Inhibitors- Market Drivers and Barriers
* Appendix

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