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Oligonucleotide Synthesis Market Forecasted to Reach USD 58.89 Billion By 2035, at an Impressive 15.2% CAGR

01-28-2026 08:27 AM CET | Health & Medicine

Press release from: market research future

Oligonucleotide Synthesis Market

Oligonucleotide Synthesis Market

Oligonucleotide Synthesis: Driving Innovation in Genetic Research and Therapeutics

The world of biotechnology is evolving rapidly, and Oligonucleotide Synthesis is at the forefront of this revolution. These short DNA or RNA sequences play a pivotal role in modern genetic research, diagnostics, and therapeutic development. From developing personalized medicines to advancing cutting-edge research in genomics, oligonucleotides are indispensable in shaping the future of healthcare.

According to Market Research Future, the Oligonucleotide Synthesis Market was valued at USD 12.38 billion in 2024. The market is expected to expand significantly, growing from USD 14.27 billion in 2025 to USD 58.89 billion by 2035, representing a compound annual growth rate (CAGR) of 15.2% over the forecast period from 2025 to 2035.

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Major Players

Thermo Fisher Scientific (US), Integrated DNA Technologies (US), Eurofins Genomics (DE), Agilent Technologies (US), Sigma-Aldrich (US), Biosearch Technologies (US), GenScript (CN), Twist Bioscience (US), Bioneer (KR)

Advancements in Oligonucleotide Synthesis have transformed how scientists approach genetic studies. Traditional methods of synthesizing DNA sequences were often time-consuming and prone to errors. Today, modern synthesis technologies offer high precision, scalability, and cost-effectiveness, allowing researchers to produce complex sequences with remarkable efficiency. This precision is crucial for applications like CRISPR gene editing, antisense therapy, and PCR-based diagnostics, where even a minor error can impact results significantly.

The growing demand for custom oligonucleotides is driven by their diverse applications in drug discovery, molecular diagnostics, and vaccine development. Pharmaceutical companies are increasingly relying on synthetic oligonucleotides to design targeted therapies, especially for genetic disorders and rare diseases. For instance, antisense oligonucleotides have shown promising results in treating conditions like spinal muscular atrophy, highlighting the therapeutic potential of these molecules.

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Moreover, the Oligonucleotide Synthesis market is witnessing robust growth due to increased investment in research and development across academic and industrial sectors. Biotechnology firms are focusing on automation and high-throughput synthesis platforms to meet the rising demand for high-quality oligonucleotides. This trend is expected to accelerate as personalized medicine and gene therapies gain wider acceptance worldwide.

Another significant aspect driving the market is the emphasis on quality and purity. Modern oligonucleotide synthesis methods ensure minimal contamination, high reproducibility, and longer shelf life, making them suitable for critical research and clinical applications. Advanced purification techniques such as HPLC and PAGE are now standard in ensuring the integrity of synthesized sequences, which is crucial for sensitive applications like RNA therapeutics.

Furthermore, collaborative efforts between research institutions and industry leaders are pushing the boundaries of innovation in oligonucleotide technology. The integration of artificial intelligence and machine learning in synthesis planning and error prediction is enhancing efficiency and reducing costs. These advancements not only improve productivity but also open new avenues for discovering novel therapies and diagnostic tools.

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About Market Research Future:
Market Research Future (MRFR) is a global market research company that takes pride in its services, offering a complete and accurate analysis with regard to diverse markets and consumers worldwide. Market Research Future has the distinguished objective of providing the optimal quality research and granular research to clients. Our market research studies by products, services, technologies, applications, end users, and market players for global, regional, and country level market segments, enable our clients to see more, know more, and do more, which help answer your most important questions.

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