Press release
mRNA Synthesis and Manufacturing Services Market Growth Driven by Increasing Demand for Infectious Disease Vaccines and Advanced Therapeutics
mRNA Synthesis and Manufacturing Services Market
Global mRNA Synthesis and Manufacturing Services Market Size is valued at USD 958.52 Mn in 2024 and is predicted to reach USD 2,294.90 Mn by the year 2034 at a 7.7% CAGR during the forecast period for 2025-2034.
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Messenger RNA (mRNA) molecules, comprising single-stranded nucleic acids transcribed from DNA, serve a critical function in gene expression by guiding the production of specific proteins within cells. Due to their inherent flexibility and adaptability, mRNA platforms have emerged as a pivotal foundation for the development of both therapeutic and prophylactic vaccines targeting a wide spectrum of infectious and chronic diseases.
Compared with traditional pharmaceutical approaches, mRNA vaccines offer enhanced immunogenicity, higher success rates, and more cost-effective manufacturing processes. The global deployment of mRNA-based COVID-19 vaccines, followed by regulatory approvals for additional viral pathogens, has markedly accelerated the demand for mRNA manufacturing capabilities.
Beyond vaccines, mRNA therapeutics exhibit significant promise for treating complex conditions, including infectious diseases, metabolic genetic disorders, oncology indications, and cardiovascular and cerebrovascular diseases. These therapies present no risk of unintended infection or insertional mutagenesis, providing a notable advantage over conventional gene therapy approaches. Additionally, mRNA enables sustained protein expression through continuous translation, yielding improved therapeutic efficacy relative to traditional protein- or peptide-based treatments.
The growth of the mRNA synthesis and manufacturing services sector is driven by the rising prevalence of rare diseases, such as propionic acidemia, methylmalonic acidemia, glycogen storage disorders, as well as metabolic and immunological disorders. Increasing incidences of chronic conditions, including cancer, cardiovascular disease, pulmonary disorders, and chronic kidney disease, are further amplifying market demand. Technological advancements in biopharmaceutical production have prompted service providers to expand manufacturing infrastructure and capacity to meet the growing requirements of this innovative therapeutic category.
Market expansion is further reinforced by the increasing number of clinical trials targeting oncology and infectious diseases. Current industry trends highlight elevated investment activity, strategic collaborations, mergers, and intensified research and development efforts. For example, in April 2021, U.S.-based mRNA company Arcturus Therapeutics entered into a joint venture with Japan's Axcelead, Inc., establishing a new entity in Chiba Prefecture and commencing construction of a manufacturing facility in Minamisoma City, Fukushima Prefecture. Such strategic initiatives are expected to significantly bolster sector growth and facilitate broader market adoption in the coming years.
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The expansion of mRNA synthesis and manufacturing services is, however, being hampered by a dearth of manufacturing procedures that are flexible, sustainable, and efficient in terms of cost. Also, the lengthy process of approvals and long-term clinical trials will hamper the market growth in the forecasting period.
The mRNA synthesis and manufacturing services market in North America will be driven by the availability of significant financing for research, the expansion of federal programmes toward RNA-based therapeutics, and the increasing number of clinical studies.
Some of the significant market players in the mRNA synthesis and manufacturing services market are eTheRNA (Etherna Immunotherapies), Eurogentec, Aldevron, biosynthesis, Biomay, Jena Biosciences, APExBIO, TriLink BioTechnologies, CELLSCRIPT, Thermo Fisher Scientific, New England Biolabs, BioNTech (Pfizer), Translate Bio, CureVac, Moderna, Ethris (AstraZeneca), Kernal Biologics, Silence Therapeutics, In-Cell-Art, Anima Biotch, H3 Biomedicine Inc., Tiba Biotechnology, Arcturus Therapeutics, Ionis Pharmaceuticals, Inc., Stemirna Therapeutics Co., Ltd., eFFECTOR Therapeutics, Inc., Ziphius Therapeutics NV, miRagen Therapeutics, Inc., RNAimmune (Sirnaomics), Skyhawk Therapeutics, Inc, Strand Therapeutics Inc., and other Prominent Players.
Key Developments in the Market :
• In Aug 2022, A novel enzymatic mRNA capping solution for the manufacture of mRNA was introduced by New England Biolabs® under the name Faustovirus Capping Enzyme. This new enzyme boosts the capping effectiveness and scalability for mRNA manufacturing workflows, including vaccine production.
• In Jan 2022, Pfizer and BioNTech signed a new global collaboration agreement to work together on developing the first mRNA-based shingles vaccine. Both Pfizer's antigen technology and BioNTech's proprietary mRNA technology will be utilised to develop potential product candidates. It is expected that clinical trials will begin in the second half of the year 2022.
• In Oct 2021, Silence Therapeutics and Hansoh Pharma announced a collaboration to develop therapeutics utilising Silence's mRNAi GOLDTM Platform. The upfront cash payment from Hansoh is expected to be sixteen million dollars, and the possible milestone payments for Silence might be as high as one billion three hundred million dollars.
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Market Segmentation:
Global mRNA Synthesis and Manufacturing Services Market, by Type of Industry 2022-2030 (Value US$ Mn)
• Therapeutics and Vaccine Developers
• CDMO Organizations
• Custom Synthesis/Other Service Providers
Global mRNA Synthesis and Manufacturing Services Market, by Applications, 2022-2030 (Value US$ Mn)
• Infectious Disease Vaccines
• Other Vaccines
• Therapeutics and Others
Global mRNA Synthesis and Manufacturing Services Market, by Scale of Operation, 2022-2030 (Value US$ Mn)
• Research / Preclinical
• Clinical
• Commercial
Global mRNA Synthesis and Manufacturing Services Market, by Region, 2022-2030 (Value US$ Mn)
• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa
North America mRNA Synthesis and Manufacturing Services Market, by Country, 2022-2030 (Value US$ Mn)
• U.S.
• Canada
Europe mRNA Synthesis and Manufacturing Services Market, by Country, 2022-2030 (Value US$ Mn)
• Germany
• France
• Italy
• Spain
• Russia
• Rest of Europe
Asia Pacific mRNA Synthesis and Manufacturing Services Market, by Country, 2022-2030 (Value US$ Mn)
• India
• China
• Japan
• South Korea
• Australia & New Zealand
Latin America mRNA Synthesis and Manufacturing Services Market, by Country, 2022-2030 (Value US$ Mn)
• Brazil
• Mexico
• Rest of Latin America
Middle East & Africa mRNA Synthesis and Manufacturing Services Market, by Country, 2022-2030 (Value US$ Mn)
• GCC Countries
• South Africa
• Rest of Middle East & Africa
•
Why should buy this report:
To receive a comprehensive analysis of the prospects for the global mRNA Synthesis and Manufacturing Services Market
To receive an industry overview and future trends of the mRNA Synthesis and Manufacturing Services Market
To analyze mRNA Synthesis and Manufacturing Services Market drivers and challenges
To get information on the mRNA Synthesis and Manufacturing Services Market size (Value US$ Mn) forecast to 2030
Significant investments, mergers & acquisitions in the mRNA Synthesis and Manufacturing Services Market industry
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InsightAce Analytic is a market research and consulting firm that enables clients to make strategic decisions. Our qualitative and quantitative market intelligence solutions inform the need for market and competitive intelligence to expand businesses. We help clients gain competitive advantage by identifying untapped markets, exploring new and competing technologies, segmenting potential markets and repositioning products. Our expertise is in providing syndicated and custom market intelligence reports with an in-depth analysis with key market insights in a timely and cost-effective manner.
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