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In-Depth Examination of Segments, Industry Developments, and Key Players in the Histidine Tag (His-Tag) Antibody Market
Histidine Tag His Tag Antibody
Market Size Forecast and Growth Potential in the Histidine Tag (His-Tag) Antibody Market
The histidine tag (His-Tag) antibody market is expected to rapidly expand, reaching a valuation of $2.22 billion by 2029. This translates to a compound annual growth rate (CAGR) of 11.6% over the forecast period. The surge is driven by factors such as the increasing demand for targeted therapies, wider use of His-Tag antibodies in drug discovery, growth in biopharmaceutical manufacturing, rising investments in biotech research, and a stronger emphasis on personalized medicine. Key trends set to influence the market include innovations in antibody engineering, improvements in purification techniques, development of high-affinity recombinant antibodies, advances in molecular tagging technologies, and automation within laboratory workflows.
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Leading Market Participants in the Histidine Tag (His-Tag) Antibody Industry
Several prominent companies dominate the histidine tag (His-Tag) antibody landscape. Key players include Thermo Fisher Scientific Inc., Danaher Corporation, Merck KGaA, Bio-Rad Laboratories Inc., GeneTex Inc., Bio-Techne Corporation, GenScript Biotech Corporation, Sino Biological Inc., Cell Signaling Technology Inc., Wuhan Elabscience Biotechnology Co. Ltd., ABclonal Technology Co. Ltd., Proteintech Group Inc., Santa Cruz Biotechnology Inc., Rockland Immunochemicals Inc., Creative Diagnostics Inc., Aviva Systems Biology Corporation, Abnova Corporation, Boster Biological Technology Co. Ltd., Columbia Biosciences Corporation, and NSJ Bioreagents.
A notable development occurred in December 2023, when Danaher Corporation, a US-based biotech firm, acquired UK-based Abcam plc for $5.7 billion. This strategic acquisition enhances Danaher's footprint in the life sciences and proteomics sectors, broadening its offerings of research reagents, antibodies, and related solutions pivotal for drug discovery and diagnostic applications. Abcam is well known for producing His-Tag antibodies used for detecting and purifying recombinant proteins.
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Key Trends and Emerging Market Opportunities in the Histidine Tag (His-Tag) Antibody Sector
Industry leaders are increasingly focusing on advanced product innovation, including the creation of automated biosensor-based His-Tag quantification kits. These kits provide fast, efficient, and standardized protein detection from both crude and purified samples. For example, in November 2025, HexagonFab Limited, operating as Abselion in the UK, launched the Tagged Protein Quantification Kit for His-tagged proteins. Developed for use with the Amperia platform and utilizing GenScript's THE His Tag monoclonal antibodies, this kit offers a rapid, mix-and-read, antibody-free solution. When paired with Abselion's Amperia biosensors, it enables real-time, label-free protein measurements, streamlining workflows by eliminating the need for multiple instruments or specialized training. This innovation aims to speed up expression screening, optimize bioprocesses, and enhance quality control through reliable His-tagged protein quantification.
Breakdown of Market Segments in the Histidine Tag (His-Tag) Antibody Industry
The histidine tag (His-Tag) antibody market is segmented across several dimensions:
1) By Product Type:
- Monoclonal Antibodies
- Polyclonal Antibodies
- Recombinant Antibodies
- Nanobodies
- Other Product Types
2) By Application:
- Western Blotting
- Immunoprecipitation
- Flow Cytometry
- Other Applications
3) By End-User:
- Pharmaceutical Companies
- Biotechnology Companies
- Academic and Research Institutions
- Contract Research Organizations (CROs)
- Other End-Users
Further subcategories provide detailed classifications:
- Monoclonal Antibodies include mouse, rabbit, rat, humanized, chimeric, and isotype control variants.
- Polyclonal Antibodies cover rabbit, goat, chicken, donkey, sheep, and serum-free types.
- Recombinant Antibodies feature recombinant rabbit and mouse monoclonals, single chain variable fragments, fragment antigen binding, multispecific engineered antibodies, and recombinant antibody pairs for capture and detection.
- Nanobodies consist of single domain antibodies derived from camelids and alpacas, fluorescent protein-fused nanobodies, enzyme-conjugated nanobodies, immobilized nanobodies for affinity purification, and intrabody nanobodies for intracellular detection.
- Other product types include secondary antibodies targeting His-tag, conjugated secondary antibodies, magnetic and agarose beads with nickel nitrilotriacetic acid, ELISA kits for histidine tag detection, and lateral flow assays.
Regional and future outlooks suggest that the market's growth will be propelled by continuous technological advances and expanding applications in drug development and bioprocessing. This positions the histidine tag (His-Tag) antibody sector as an essential and rapidly evolving part of the biotechnology landscape.
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With over 17500+ reports from 27 industries covering 60+ geographies, The Business Research Company has built a reputation for offering comprehensive, data-rich research and insights. Armed with 1,500,000 datasets, the optimistic contribution of in-depth secondary research, and unique insights from industry leaders, you can get the information you need to stay ahead.Our flagship product, the Global Market Model (GMM), is a premier market intelligence platform delivering comprehensive and updated forecasts to support informed decision-making.
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