Press release
Moderate to Severe Psoriasis Market is projected to reach USD 47.68 billion by 2034
The global Moderate to Severe Psoriasis Market was valued at USD 24.73 billion in 2024 and is projected to reach USD 47.68 billion by 2034, growing at a CAGR of 6.8% during the forecast period (2025-2034). Growth is driven by rising global psoriasis prevalence, rapid adoption of biologics, strong expansion of IL-17 and IL-23 inhibitors, increasing use of oral targeted therapies, and greater clinical recognition of psoriasis as a systemic inflammatory disease associated with significant comorbidities.Download Full PDF Sample Copy of Market Report @ https://exactitudeconsultancy.com/request-sample/71343
Moderate to severe psoriasis affects approximately 20-30% of the global psoriasis population and typically requires systemic therapies, phototherapy, or biologic interventions. These patients experience higher rates of psoriatic arthritis, cardiovascular disease, obesity, depression, and metabolic disorders, which supports strong therapy demand across the long-term treatment cycle.
Key Market Highlights
• 2024 Market Size: USD 24.73 billion
• 2034 Forecast: USD 47.68 billion
• CAGR (2025-2034): 6.8%
• Largest Therapy Class: IL-17 and IL-23 inhibitors
• Fastest-Growing Segment: JAK inhibitors & next-generation biologics
Epidemiology & Patient Population Insights
1. Global Psoriasis Prevalence
• ~125 million people have psoriasis worldwide.
• Moderate to severe forms affect 25-35 million individuals.
2. Disease Severity Definition
Moderate to severe psoriasis typically includes:
• PASI score: ≥10
• BSA involvement: >10%
• DLQI: major quality-of-life impairment
3. Major Comorbidities
Moderate to severe patients have increased risk of:
• Psoriatic arthritis
• Cardiovascular disease
• Type 2 diabetes
• Hypertension
• Depression and anxiety
• Nonalcoholic fatty liver disease
These comorbidities increase systemic therapy utilization.
Market Growth Drivers
1. Exceptional Adoption of Biologics
Leading biologic classes driving growth:
• IL-17 inhibitors
• IL-23 inhibitors
• TNF inhibitors
These agents offer rapid, durable skin clearance with strong safety profiles.
2. Rising Use of Oral Targeted Therapies
PDE4 inhibitors and JAK inhibitors are increasingly used for patients who prefer oral therapy or do not qualify for injectables.
3. Expanding Psoriatic Arthritis (PsA) Co-diagnosis
Up to 30% of psoriasis patients develop PsA, boosting biologic utilization.
4. Increasing Access to Dermatology Care
Teledermatology accelerates diagnosis and long-term disease management.
5. Growing Awareness of Systemic Psoriasis Burden
Governments and dermatology societies promote early intervention for moderate to severe cases.
Market Restraints
• High cost of biologics and targeted therapies
• Reimbursement challenges in developing regions
• Long-term immunosuppression risks
• Diagnostic delays in underserved populations
Market Opportunities
1. Next-Generation IL-23 Inhibitors
Longer dosing intervals and improved safety offer strong growth prospects.
2. Expansion of JAK Inhibitors
Short-term flare control and systemic inflammation reduction broaden their adoption.
3. Personalized Dermatology & Biomarkers
Pharmacogenomic testing and cytokine signatures will guide therapy selection.
4. AI-Based PASI Scoring Tools
Improves accuracy in severity assessment for telemedicine and clinic use.
5. Biosimilars for TNF and IL-17 Inhibitors
Creates affordability and increases biologic penetration globally.
Segmentation Overview
By Treatment Type
• Biologics
o IL-17 inhibitors
o IL-23 inhibitors
o TNF inhibitors
o IL-12/23 inhibitors
• Systemic therapies
• Oral targeted therapies (PDE4 & JAK inhibitors)
• Phototherapy
• Topical adjunct therapies
By Route of Administration
• Injectable (SC/IV)
• Oral
• Topical (supportive care)
By Patient Group
• Adults
• Adolescents
• Pediatric (emerging approvals)
By End User
• Hospitals
• Dermatology clinics
• Specialty infusion centers
• Retail & online pharmacies
Explore Full Report here: https://exactitudeconsultancy.com/reports/71343/moderate-to-severe-psoriasis-market
Regional Insights
North America - Largest Market
High biologic penetration, strong reimbursement coverage, and significant PsA comorbidity burden.
Europe - Widely Adopted Biologic Treatment Pathways
NICE/EADV guidelines drive structured use of advanced therapies.
Asia Pacific - Highest Growth Rate
Large population, urbanization, pollution, and rising healthcare access.
Latin America - Expanding Dermatology Care
Growing awareness and improving therapeutic access.
Middle East & Africa - Emerging
Infrastructure expansion supports gradual adoption.
Competitive Landscape
Key companies active in moderate to severe psoriasis therapy development include:
• Novartis
• Eli Lilly
• AbbVie
• Johnson & Johnson (Janssen)
• Amgen
• UCB Pharma
• Pfizer
• Bristol Myers Squibb
• Sun Pharma
• LEO Pharma
Focus areas: IL-17/IL-23 inhibition, next-generation biologics, JAK inhibitors, and topical innovation.
Recent Market Developments
• New IL-23 inhibitors showing multi-year sustained skin clearance
• Expansion of biologics into pediatric and adolescent populations
• Increased real-world data validating JAK inhibitor effectiveness
• Significant AI integration for remote PASI scoring
• Biosimilar launches improving biologic affordability
Future Outlook (2025-2034)
The Moderate to Severe Psoriasis Market will grow rapidly as:
• Biologics continue expanding globally
• Oral targeted therapies gain broader acceptance
• Precision medicine guides treatment pathways
• Digital dermatology improves triage and diagnosis
• New-generation IL-23 and IL-17 biologics reshape long-term care
By 2034, the market is forecasted to reach USD 47.68 billion, supported by strong innovation in immunology and rising treatment demand among high-severity patients.
This report is also available in the following languages : Japanese (中等度から重度の乾癬市場), Korean (중등도에서 중증 건선 시장), Chinese (中重度银屑病市场), French (Marché du psoriasis modéré à sévère), German (Markt für mittelschwere bis schwere Psoriasis), and Italian (Mercato della psoriasi da moderata a grave), etc.
Request for a sample of this research report at (Use Corporate Mail ID for Quick Response) @ https://exactitudeconsultancy.com/request-sample/71343
Our More Reports:
Moderate to Severe Plaque Psoriasis ( ONLY CANADA DATA) Market
https://exactitudeconsultancy.com/reports/71425/moderate-to-severe-plaque-psoriasis-only-canada-data-market
Phototherapies for Psoriasis Market
https://exactitudeconsultancy.com/reports/71430/phototherapies-for-psoriasis-market
Concussion Market
https://exactitudeconsultancy.com/reports/72676/concussion-market
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https://exactitudeconsultancy.com/reports/76109/alzheimer-s-disease-treatment-market
About Us
Exactitude Consultancy is a market research & consulting services firm which helps its client to address their most pressing strategic and business challenges. Our market research helps clients to address critical business challenges and also helps make optimized business decisions with our fact-based research insights, market intelligence, and accurate data.
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