Anal Cancer Market Size (US) was ~USD 7 million in 2023, which is further expected to increase by 2034, estimates DelveInsight

DelveInsight's "Anal Cancer Market Insights, Epidemiology, and Market Forecast-2034′′ report offers an in-depth understanding of the Anal Cancer, historical and forecasted epidemiology as well as the Anal Cancer market trends in the United States, EU4 (Germany, Spain, Italy, France) the United Kingdom and Japan.

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Key Takeaways from Anal Cancer Market Report
• The United States accounted for the highest cases of incident cases of anal cancer among the 7MM countries, which is expected to increase at a CAGR of 3.6% for the study period i.e. 2020-2034.
• In 2023, in the United States, approximately 82% of patients who tested positive for HPV were diagnosed with anal cancer, with HPV being the primary causative factor.
• EU4 and the UK collectively accounted for nearly 9,000 incident cases of anal cancer in 2023, which is likely to increase by 2034. Among the EU4 countries, Germany accounted for the highest number of incident cases of anal cancer.
• In Japan, there is a different trend compared to other 6MM markets regarding histology-specific cases of anal cancer. While Squamous Cell Carcinoma (SCC) accounts for the highest number of cases in other markets, in Japan, the highest histology-specific cases are accounted for by Adenocarcinoma and other types, followed by SCC type.
• Among EU4 and the UK, Germany accounted for the highest Anal cancer market size, which was approximately USD 1 million in 2023.
• In 2023, Japan accounted for approximately 2% market share of anal cancer, which is expected to increase during the study period (2020-2034).
• The launch of the retifanlimab is expected to transform the treatment landscape, potentially becoming a market leader in the 7MM by 2034.
• The leading Anal Cancer Companies such as Incyte Corporation, BioMimetix and others.
• Promising Anal Cancer Therapies such as Retifanlimab, BMX-001 and others.

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Anal Cancer Overview
Anal cancer is a rare type of cancer that begins in the tissues of the anus, which is the opening at the end of the digestive tract through which stool leaves the body. It typically develops from the cells lining the anal canal and is most commonly related to infection with the human papillomavirus (HPV). While early symptoms may be subtle, they can include rectal bleeding, pain, itching, or a lump near the anal region. Risk factors include HPV infection, smoking, weakened immune systems, and certain sexual practices. Anal cancer is often treatable when diagnosed early, and management may involve a combination of chemotherapy, radiation therapy, and sometimes surgery, depending on the stage and extent of the disease.

Anal Cancer Epidemiology Segmentation in the 7MM
• Incident Cases of Anal Cancer
• Anal Cancer Gender-specific Cases
• Anal Cancer Age-specific Cases
• Anal Cancer Histology-specific Cases
• Anal Cancer HPV Status-specific Cases
• Anal Cancer Stage-specific Cases
• Anal Cancer Linewise Treated Cases

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Anal Cancer Treatment Market
The Anal Cancer treatment landscape is undergoing substantial changes with ongoing research and studies encompassing chemotherapy, immunotherapy, radiation therapy, and innovative combinations throughout the different stages of ASCC. These advancements in therapeutic exploration are indicative of a dynamic and evolving field with the potential to enhance treatment options and outcomes for individuals with anal cancer.

Anal Cancer Emerging Therapies
• Retifanlimab: Incyte Corporation
Retifanlimab (formerly INCMGA0012), an investigational intravenous anti-PD1 antibody, is currently under evaluation in registration-directed trials as a monotherapy for patients with microsatellite instability-high endometrial cancer and squamous cell carcinoma of the anal canal. Currently, the drug is being evaluated in the POD1UM-303/InterAACT 2 (NCT04472429) Phase III clinical trial.

• BMX-001: BioMimetix
BioMimetix is pioneering the advancement of BMX-001, a novel class of small molecules known as redox-active metalloporphyrins (MnPs), which have demonstrated robust anti-inflammatory effects. The mechanism of action of BMX-001 involves a dual impact on tumor cells and normal tissues. In tumor cells, BMX-001 inhibits the NF-?B and HIF-1?? pathways, leading to heightened tumor cell destruction, angiogenesis inhibition, and decreased long-term tumor proliferation. Currently, the company is recruiting patients in its Phase I/II clinical trial of patients with newly diagnosed anal cancer.

Anal Cancer Drugs Uptake and Pipeline Development Activities
The drugs uptake section focuses on the rate of uptake of the potential drugs recently launched in the Anal Cancer market or expected to get launched during the study period. The analysis covers Anal Cancer market uptake by drugs, patient uptake by therapies, and sales of each drug. Moreover, the therapeutics assessment section helps understand the drugs with the most rapid uptake and the reasons behind the maximal use of the drugs. Additionally, it compares the drugs based on market share. The report also covers the Anal Cancer Pipeline Development Activities. It provides valuable insights about different therapeutic candidates in various stages and the key companies involved in developing targeted therapeutics. It also analyzes recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.

Anal Cancer Market Outlook
The first-line treatment option for locoregional anal cancer is combination chemoradiotherapy (CRT). The exception is early-stage perianal disease excluding the anal sphincter and superficially invasive SCC of the anus, for which wide local excision is a treatment option. In anal cancer, the treatment paradigm has shifted from surgery to combined chemoradiation therapy. With this shift, the function of the anus could be preserved. After several randomized trials of induction chemotherapy, maintenance chemotherapy, and planned treatment breaks, the combination of MMC, 5-FU, and RT, without induction or maintenance chemotherapy or treatment breaks, remains the standard of care. Over the past decade, intensity-modulated radiotherapy (IMRT) has replaced older treatment techniques as the standard of care. Moreover, strategies to decrease radiation-associated toxicities are an additional focus of current research on SCCA. A potential strategy to decrease hematologic toxicity is bone marrow-sparing IMRT. Immunotherapy is presently recommended as a second-line treatment option in the metastatic setting but is currently being explored in the locoregional setting. Immune checkpoint inhibitors (ICI) have been an active focus of recently published studies on patients with locoregional SCCA.

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Scope of the Anal Cancer Market Report
• Study Period: 2020-2034
• Coverage: 7MM
• Anal Cancer Companies- Incyte Corporation, BioMimetix and others.
• Anal Cancer Therapies- Retifanlimab, BMX-001 and others.
• Anal Cancer Therapeutic Assessment: Anal Cancer current marketed and Anal Cancer emerging therapies
• Anal Cancer Market Dynamics: Anal Cancer market drivers and Anal Cancer market barriers
• Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies
• Anal Cancer Unmet Needs, KOL's views, Analyst's views, Anal Cancer Market Access and Reimbursement

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Table of Contents
1. Anal Cancer Market Report Introduction
2. Executive Summary for Anal Cancer
3. SWOT analysis of Anal Cancer
4. Anal Cancer Patient Share (%) Overview at a Glance
5. Anal Cancer Market Overview at a Glance
6. Anal Cancer Disease Background and Overview
7. Anal Cancer Epidemiology and Patient Population
8. Country-Specific Patient Population of Anal Cancer
9. Anal Cancer Current Treatment and Medical Practices
10. Anal Cancer Unmet Needs
11. Anal Cancer Emerging Therapies
12. Anal Cancer Market Outlook
13. Country-Wise Anal Cancer Market Analysis
14. Anal Cancer Market Access and Reimbursement of Therapies
15. Anal Cancer Market Drivers
16. Anal Cancer Market Barriers
17. Anal Cancer Appendix
18. Anal Cancer Report Methodology
19. DelveInsight Capabilities
20. Disclaimer
21. About DelveInsight

About Us

DelveInsight is a leading healthcare-focused market research and consulting firm that provides clients with high-quality market intelligence and analysis to support informed business decisions. With a team of experienced industry experts and a deep understanding of the life sciences and healthcare sectors, we offer customized research solutions and insights to clients across the globe. Connect with us to get high-quality, accurate, and real-time intelligence to stay ahead of the growth curve.

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