Polyrizon (NASDAQ: PLRZ) Soars as Superior Mucoadhesion Naloxone Hydrogel Signals Stronger Real-World Opioid Overdose Reversal Potential

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Polyrizon Ltd. (Nasdaq: PLRZ) soars in after-hours and pre-market trading after announcing powerful new preclinical data demonstrating that its proprietary intranasal naloxone hydrogel exhibits significantly superior mucoadhesion compared to a marketed intranasal naloxone spray yesterday - a critical performance advantage for real-world opioid overdose emergencies.

Using an established ex-vivo rabbit nasal mucosa model, researchers compared the persistence of Polyrizon's hydrogel to a commercial naloxone product under repeated washing with Simulated Nasal Electrolyte Solution (SNES). Polyrizon's Trap & Target Trademark (T&T) hydrogel retained dramatically higher fluorescence levels, with results reaching p < 0.0001, demonstrating far stronger and more durable mucosal adhesion.

Enhanced mucoadhesion is a key driver of intranasal drug delivery performance - particularly for emergency opioid overdose reversal - because increased nasal residence time supports more reliable absorption and potentially faster onset of action.

"These results further validate the potential of our T&T hydrogel platform," said Tomer Izraeli, CEO of Polyrizon. "Outperforming a marketed product in mucoadhesion is a significant milestone for our Naloxone program."

The new findings build on Polyrizon's previously reported stability data, reinforcing the Company's positioning in intranasal drug delivery, biodefense, and next-generation hydrogel-based therapeutics. With global opioid overdose deaths continuing to rise, Polyrizon's innovation may represent a meaningful improvement in emergency response tools.

Investors now anticipate next steps including preclinical advancement, regulatory pathway updates, and future clinical development as Polyrizon moves toward what could become a best-in-class intranasal naloxone product. For more information, visit www.polyrizon-biotech.com [http://www.polyrizon-biotech.com/].

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