Press release
Tangential Flow Filtration (TFF) Market to Reach USD 4.63 Billion by 2030
TFF-also known as crossflow filtration-is essential for producing monoclonal antibodies (mAbs), viral vectors, recombinant proteins, vaccines, plasma products, and nucleic-acid-based therapies (including mRNA therapeutics).
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Key Takeaways
• Market Size 2023: USD 2.14 billion
• Market Size 2030: USD 4.63 billion
• CAGR (2024-2030): 11.7%
• Top Demand Drivers: Biologics boom, CGT expansion, mRNA vaccine/therapy growth, and increased downstream purification needs.
• Largest Product Segment: Single-use TFF systems as modular plants become the industry standard.
Market Story
The biopharma industry is transitioning toward high-purity, flexible, and scalable downstream processing systems. Tangential Flow Filtration has become a critical step due to its efficiency, minimal clogging, high recovery yield, and compatibility with sensitive biomolecules.
TFF is now indispensable in:
• Monoclonal antibody (mAb) manufacturing
• AAV, lentiviral, and adenoviral vector purification
• mRNA and LNP (lipid nanoparticle) processing
• Plasma fractionation
• Recombinant protein concentration/exchange
• Cell harvesting and clarification
The rise of cell & gene therapy, personalized medicine, and mRNA technologies is accelerating TFF adoption across both clinical-stage and commercial GMP facilities.
Market Segments
By Product Type
• Single-Use TFF Systems (Largest and Fastest Growing)
• Reusable TFF Systems
• TFF Cassettes & Modules
• TFF Filters & Membranes
• Accessories & Fittings
• Automated TFF Skids
Single-use systems lead due to reduced cleaning validation and contamination risks.
By Membrane Material
• Polyethersulfone (PES) (Most Widely Used)
• Regenerated Cellulose (RC)
• PVDF
• Other High-Performance Polymers
PES remains dominant due to its stability, throughput, and broad pH tolerance.
By Technique
• Ultrafiltration (UF) (Largest Share)
• Microfiltration (MF)
• Diafiltration (DF)
• Permeate Flow TFF
• Nanofiltration (NF)
Ultrafiltration is widely used for mAbs, proteins, and viral vector purification.
By Application
• Monoclonal Antibody Production
• Viral Vector Processing (AAV, Lentivirus, Adenovirus)
• mRNA & LNP Filtration
• Vaccine & Plasma Product Manufacturing
• Recombinant Protein Processing
• Buffer Exchange & Desalting
• Cell Harvesting & Clarification
Vector purification and mRNA workflows are the fastest-growing applications.
By End User
• Biopharmaceutical & Biotechnology Companies
• CDMOs & CMOs (Fastest Growing User Group)
• Academic & Research Institutes
• Vaccine Manufacturers
• Diagnostic and Specialty Biotech Firms
CDMOs lead adoption due to multi-client bioproduction needs.
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Recent Industry Developments
• 2024 - Sartorius expanded its single-use TFF portfolio for viral vector and mRNA manufacturing.
• 2024 - Merck KGaA (MilliporeSigma) launched next-gen TFF membrane modules optimized for high-titer mAb production.
• 2023 - Cytiva (Danaher) enhanced its ÄKTA and ReadyToProcess TFF platforms for GMP scalability.
• 2023 - Pall Corporation introduced automated TFF solutions integrated with PAT tools.
• 2023 - Repligen launched high-performance TFF cassettes for gene therapy applications.
Expert Quote
"Tangential Flow Filtration is the backbone of modern biologics and advanced therapy manufacturing. As mRNA, viral vectors, and cell therapies scale globally, TFF will continue to drive downstream efficiency and product purity."
- Irfan Tamboli, Business Development Executive, Exactitude Consultancy
Key Market Drivers
1. Expansion of Biologics & Biosimilars
Global mAb pipelines and biosimilar approvals require high-throughput TFF systems.
2. Surge in Cell & Gene Therapy Pipelines
TFF supports ultrafiltration and buffer exchange for viral vector production.
3. Rapid Adoption of mRNA Vaccines & Therapeutics
mRNA encapsulated in lipid nanoparticles (LNPs) relies heavily on TFF purification.
4. Shift Toward Single-Use Bioprocessing
Single-use TFF systems reduce contamination risks and enhance operational flexibility.
5. Regulatory Emphasis on High-Purity Biomanufacturing
GMP compliance demands robust, reproducible filtration techniques.
Forecast Outlook (2024-2030)
Future growth will be driven by:
• AI-assisted TFF process optimization
• Larger-scale single-use filtration systems
• Hybrid stainless-steel & single-use facilities
• Increased adoption in high-titer vector manufacturing
• PAT-integrated automated TFF skids
By 2030, fully automated, closed-loop TFF systems will dominate biologics downstream processing.
Regional Insights
North America
Largest market due to strong biologics pipelines and advanced manufacturing infrastructure.
Europe
High adoption supported by biosimilar development and expanding CGT manufacturing.
Asia-Pacific
Fastest-growing region (CAGR > 13%) driven by China, India, South Korea, and Singapore biopharma investments.
Latin America & Middle East
Growth supported by modernization of vaccine and plasma product manufacturing.
Conclusion
The Tangential Flow Filtration Market is positioned for strong growth as biologics, mRNA, and cell & gene therapy production accelerate worldwide. With continued innovation in membranes, automation, and single-use systems, TFF will remain central to high-purity bioprocessing through 2030.
This report is also available in the following languages : Japanese (タンジェンシャルフローろ過市場), Korean (접선 흐름 여과 시장), Chinese (切向流过滤市场), French (Marché de la filtration à flux tangentiel), German (Markt für Tangentialflussfiltration), and Italian (Mercato della filtrazione a flusso tangenziale), etc.
Request for a sample of this research report at (Use Corporate Mail ID for Quick Response) @ https://exactitudeconsultancy.com/request-sample/73500
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About Us
Exactitude Consultancy is a market research & consulting services firm which helps its client to address their most pressing strategic and business challenges. Our market research helps clients to address critical business challenges and also helps make optimized business decisions with our fact-based research insights, market intelligence, and accurate data.
https://bulletin.exactitudeconsultancy.com/
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https://www.analytica.global/
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https://exactitudeconsultancy.com/
Connect Us:
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PHONE NUMBER +1 (704) 266-3234
EMAIL ADDRESS: sales@exactitudeconsultancy.com
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