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Cytokine Release Syndrome Management Market on Track for Strong Growth, Estimated to Grow at 6.4% CAGR Through 2029

11-21-2025 07:59 AM CET | Health & Medicine

Press release from: The Business Research Company

Cytokine Release Syndrome Management

Cytokine Release Syndrome Management

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What Is the Expected CAGR for the Cytokine Release Syndrome Management Market Through 2025?
The market concerned with managing cytokine release syndrome has experienced robust expansion lately, projected to advance from a valuation of $22.32 billion in 2024 to $23.76 billion in the subsequent year, reflecting a consistent annualized growth rate (CAGR) of 6.5%; this upward trend during the historical span is explainable by several factors, including escalating healthcare spending, greater public knowledge, shifts in lifestyle patterns, substantial disposable income levels, the uptake of individualized medical treatments, and a greater utilization of therapies focused on specific targets.

What's the Projected Size of the Global Cytokine Release Syndrome Management Market by 2029?
Forecast analysis indicates the market encompassing management of cytokine release syndrome is poised for substantial expansion, projected to reach a valuation of $30.48 billion by the year 2029, reflecting a compound annual growth rate of 6.4% throughout this period; this upward trajectory is fueled by several key factors, including escalating requirements for both diagnostic capabilities and therapeutic interventions, augmented financial support from governmental bodies, an increased necessity for efficacious treatment modalities, the demographic shift towards an older population, and proactive efforts undertaken by both public sector entities and private corporations.

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Top Growth Drivers in the Cytokine Release Syndrome Management Industry: What's Accelerating the Market?
The escalating adoption of precision-based treatments is anticipated to fuel the expansion of the market dedicated to managing cytokine release syndrome in the coming period.These specialized treatments, or targeted therapies, function by specifically inhibiting the proliferation and dissemination of malignancies through intervention on the molecular pathways critical for tumor formation.The primary rationale behind the greater utilization of these targeted modalities stems from their capacity to zero in on cancerous cells with high accuracy, concurrently lessening harm to surrounding healthy tissues, thereby boosting therapeutic outcomes while mitigating adverse reactions relative to older treatment paradigms.Effective oversight of cytokine release syndrome becomes necessary for maximizing the benefits of these targeted approaches by keeping severe inflammatory responses in check, which consequently boosts both the safety profile and the efficacy of interventions like CAR-T cell therapy and immune checkpoint inhibitors.Illustratively, data reported in January 2024 by the American Society of Gene and Cell Therapy, an organization centered in the US focusing on cell and gene-based treatments, revealed that during the final three months of 2023, the count of gene therapies advancing through Phase III trials experienced a 10% augmentation, representing the initial quarterly increase of this nature observed since the span encompassing the third quarter of 2022.Consequently, the growing deployment of targeted therapies serves as a significant impetus for the advancement of the market concerned with cytokine release syndrome treatment.

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What Trends Will Shape the Cytokine Release Syndrome Management Market Through 2029 and Beyond?
Industry leaders within the cytokine release syndrome management sector are primarily concentrating their efforts on advancing novel treatment modalities, specifically host-directed small molecule pharmaceuticals, through comprehensive clinical investigations; these drugs are engineered to fine-tune the immune system's reaction and mitigate the intensity of cytokine storms, all while assuring that the body's essential defenses against pathogens or malignancies remain functional. Such a host-directed small molecule therapeutic represents a modest-sized chemical entity designed to engage the host's immunological signaling cascades to dampen the overproduction of cytokines, effectively assisting in the control of CRS by preempting excessive immune system activation. To illustrate this development, the US biotechnology firm CytoAgents Inc. revealed in April 2025 the successful conclusion of the initial dose-escalation group within their ongoing Phase 1b/2a evaluation of CTO1681, an experimental host-directed small molecule drug engineered for both the prophylaxis and treatment of CRS in individuals undergoing CAR T-cell treatments. This exploratory intervention exhibited an encouraging safety assessment, registering neither dose-limiting adverse effects nor any detriment to the performance of the CAR T-cells; the ongoing study employs a sequential six-dose escalation structure to ascertain CTO1681's safety, its acceptability, initial effectiveness, and ultimately to pinpoint the appropriate dosage level for subsequent Phase 2 studies.

What Are the Main Segments in the Cytokine Release Syndrome Management Market?
The cytokine release syndrome managementmarket covered in this report is segmented -

1) By Treatment Type: Monoclonal Antibodies; Corticosteroids; Intravenous Immunoglobulin (IVIG); Targeted Therapy; Supportive Care; Other Treatment Types
2) By Indication: Chimeric Antigen Receptor (CAR) T-Cell Therapy; Immune Checkpoint Inhibitors; Hematopoietic Stem Cell Transplantation (HSCT); Autoimmune Diseases; Infections; Other Indications
3) By Route Of Administration: Intravenous (IV); Subcutaneous (SC); Oral; Intramuscular (IM); Intrathecal; Other Routes Of Administration
4) By End Users: Hospital Pharmacies; Retail Pharmacies; Online Pharmacies; Specialty Clinics; Research Institutions; Other End Users

Subsegments:
1) By Monoclonal Antibodies: Tocilizumab; Siltuximab; Infliximab; Rituximab; Other Monoclonal Antibodies
2) By Corticosteroids: Dexamethasone; Prednisone; Methylprednisolone; Hydrocortisone; Other Corticosteroids
3) By Intravenous Immunoglobulin (IVIG): Immunoglobulin G (IgG)-Based Intravenous Immunoglobulin; Immunoglobulin A (IgA)-Based Intravenous Immunoglobulin; Immunoglobulin M (IgM)-Based Intravenous Immunoglobulin; Polyvalent Intravenous Immunoglobulin; Other Types of Intravenous Immunoglobulin
4) By Targeted Therapy: Janus Kinase (JAK) Inhibitors; Interleukin-6 (IL-6) Inhibitors; Tumor Necrosis Factor-Alpha (TNF-a) Inhibitors; Bruton's Tyrosine Kinase (BTK) Inhibitors; Other Targeted Agents
5) By Supportive Care: Antipyretic Medications; Analgesic Medications; Intravenous Fluids And Electrolyte Solutions; Oxygen Therapy; Vasopressor Agents
6) By Other Treatment Types: Plasmapheresis (Therapeutic Plasma Exchange); Antihistamine Medications; Leukapheresis; Experimental Therapies; Nutritional Support

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Which Top Companies are Driving Growth in the Cytokine Release Syndrome Management Market?
Major companies operating in the cytokine release syndrome management market are Pfizer Inc., Johnson & Johnson Private Limited, F. Hoffmann-La Roche Ltd., AbbVie Inc., Sanofi S.A., Bristol Myers Squibb Company, Novartis AG, GlaxoSmithKline plc, Amgen Inc., Gilead Sciences Inc., Regeneron Pharmaceuticals Inc., Genentech Inc., Incyte Corporation, Swedish Orphan Biovitrum AB, Biocon Limited, MacroGenics Inc., Legend Biotech Corporation, Bluebird Bio Inc., InflaRx N.V., Humanigen Inc.

Which Regions Will Dominate the Cytokine Release Syndrome Management Market Through 2029?
North America was the largest region in the cytokine release syndrome management market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the cytokine release syndrome management market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

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With over 17500+ reports from 27 industries covering 60+ geographies, The Business Research Company has built a reputation for offering comprehensive, data-rich research and insights. Armed with 1,500,000 datasets, the optimistic contribution of in-depth secondary research, and unique insights from industry leaders, you can get the information you need to stay ahead.
Our flagship product, the Global Market Model (GMM), is a premier market intelligence platform delivering comprehensive and updated forecasts to support informed decision-making.

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Learn More About The Business Research Company
With over 17500+ reports from 27 industries covering 60+ geographies, The Business Research Company has built a reputation for offering comprehensive, data-rich research and insights. Armed with 1,500,000 datasets, the optimistic contribution of in-depth secondary research, and unique insights from industry leaders, you can get the information you need to stay ahead.Our flagship product, the Global Market Model (GMM), is a premier market intelligence platform delivering comprehensive and updated forecasts to support informed decision-making.

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