Global Human Liver Model Market: Major Trends Reshaping the Future of the Industry

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What Will the Human Liver Model Industry Market Size Be by 2025?
The scale of the human liver model market has experienced swift expansion lately, projected to increase from $2.34 billion in 2024 to reach $2.62 billion in 2025, reflecting an 11.9% compound annual growth rate; this upward trajectory during the past period stems from factors such as the demand for novel drug development processes, progress in biotechnological fields, the search for substitutes to animal testing methodologies, an increase in prevalent liver ailments, and evolving regulatory requirements placed upon research.

What's the Long-Term Growth Forecast for the Human Liver Model Market Size Through 2029?
Anticipation points toward substantial expansion within the human liver model marketplace over the coming years, projecting a valuation of $4.39 billion by the year 2029, underpinned by a compound annual growth rate (CAGR) of 13.7%; this upward trajectory is fueled by factors such as the incorporation of artificial intelligence and machine learning, the emergence of models derived from actual patients, advancements in bioengineering, the growing necessity for drug safety and toxicity evaluations, and the increasing adoption of in silico or virtual clinical trial methodologies.

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What Are the Key Growth Drivers Fueling the Human Liver Model Market Expansion?
The increasing prevalence of hepatic ailments is anticipated to boost the expansion of the human liver model sector moving ahead. Liver disease encompasses any condition affecting the liver that impairs or prevents its proper operation. Utilizing human liver models presents a developing research avenue capable of enhancing comprehension of liver pathologies and advancing pharmaceutical development; consequently, the surge in liver disease occurrences is driving the market for human liver models. To illustrate this trend, data from Cancer Australia, a governmental cancer organization based in Australia, indicated that approximately 2,905 new instances of liver cancer were identified in Australia during 2022 (comprising 2,113 cases among males and 792 among females) in September of that year. Moreover, projections suggest that the probability of developing liver cancer by the age of 85 in 2022 stood at 1 in 103 overall, translating to 0.97%, with the risk estimated at 1 in 70 or 1.4% for males and 1 in 195 or 0.51% for females. This growing incidence of liver diseases solidifies the upward momentum for the human liver model market.

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What Are the Key Trends Driving Human Liver Model Market Growth?
A significant movement within the marketplace for human liver models centers on novel product development, which is rapidly gaining traction. Leading firms engaged in this sector are focusing their efforts on engineering cutting-edge offerings as a means to solidify their standing. Specifically, in April 2023, LifeNet Health Life Sciences, an entity based in the US specializing in human cell and tissue solutions, introduced TruVivo, a revolutionary liver system constructed entirely from human cells, designed to facilitate essential preclinical investigations into novel therapeutic agents and chemical compounds. This advanced 2D+ methodology successfully integrates the detailed data fidelity characteristic of 3D constructs alongside the ease of use and adaptability inherent in 2D platforms.

How Is the Human Liver Model Market Segmented?
The human liver modelmarket covered in this report is segmented -

1) By Product: Liver Organoids; Liver-On-A-Chip; 2D Models; Animal Models; 3D Bioprinting
2) By Application: Educational; Drug Discovery; Other Applications
3) By End Users: Research Institutes; Pharmaceutical Companies; Other End Users

Subsegments:
1) By Liver Organoids: Primary Liver Organoids; Induced Pluripotent Stem Cell (iPSC)-Derived Organoids
2) By Liver-On-A-Chip: Microfluidic Liver Chips; Multi-Organ Chip Systems
3) By 2D Models: Liver Cell Cultures; Liver Cell Lines
4) By Animal Models: Rodent Models; Large Animal Models
5) By 3D Bioprinting: Bioprinted Liver Tissues; Hybrid Bioprinted Models

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Which Companies Are Leading the Charge in Human Liver Model Market Innovation?
Major companies operating in the human liver model market include Corning Incorporated, EISCO Scientific LLC, BioIVT LLC, Cyprotex plc, Emulate Inc., Cellink AB, Nortis Inc., InSphero AG, CN Bio Innovations Ltd., TissUse GmbH, Ascendance Biotechnology Inc., HemoShear Therapeutics Inc., Cyfuse Biomedical, MIMETAS BV, Biopredic International Sarl, ZenBio, Hurel Corporation, Regenovo, Pandorum, Organovo Holdings Inc., BICO Group, Hepregen Corporation, Kirkstall Ltd., HepaLife Technologies Inc., Cellaïon SA.

Which Regions Are Leading the Global Human Liver Model Market in Revenue?
North America was the largest region in the human liver model market in 2024. The regions covered in the human liver model market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

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