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Quince Therapeutics Reports Favorable iDSMB Safety Review for eDSP in Ongoing Phase 3 NEAT Trial for Ataxia Telangiectasia

11-11-2025 06:13 PM CET | Health & Medicine

Press release from: DelveInsight Business Research

Quince Therapeutics Reports Favorable iDSMB Safety Review

Quince Therapeutics, Inc. (Nasdaq: QNCX), a late stage biotechnology company focused on leveraging a patient's own biology to treat rare diseases, announced that its ongoing pivotal Phase 3 trial of encapsulated dexamethasone sodium phosphate (eDSP) in patients with Ataxia Telangiectasia has passed a key safety milestone. The independent data and safety monitoring board (iDSMB) conducted a pre planned safety review and found no safety concerns, recommending the study continue without modification.

The trial named NEAT (Neurological Effects of eDSP in Subjects with Ataxia Telangiectasia; NCT06193200/IEDAT 04 2022) is an international, multicenter, randomized, double blind, placebo controlled study evaluating eDSP in Ataxia Telangiectasia patients. The therapy uses Quince's proprietary Autologous Intracellular Drug Encapsulation (AIDE) platform to encapsulate dexamethasone sodium phosphate in a patient's own red blood cells, aiming to deliver corticosteroid efficacy while reducing the side effect burden of chronic steroid use.

According to the company, the safety review reaffirms confidence in the favourable safety profile of eDSP to date. The CEO/CMO Dirk Thye, M.D. noted the company remains on track to report topline results in the first quarter of 2026.
With no modifications recommended by the iDSMB, Quince can continue the Phase 3 NEAT trial as designed, providing a clearer path forward toward a potential first to market treatment for A T, a rare and serious neurological disease with significant unmet need. The positive review may support investor confidence, regulatory dialogue, and future commercial strategy.

Unlock comprehensive insights on Ataxia Telangiectasia, explore market trends, epidemiology, and forecasts through 2034 to drive strategic decisions.
https://www.delveinsight.com/report-store/ataxia-telangiectasia-at-market?utm_source=openpr&utm_medium=pressrelease&utm_campaign=gpr

How a DelveInsight Report Helps in Keen Market Research
DelveInsight offers comprehensive, indication and therapy area specific reports that include epidemiology, market size, forecasting, pipeline analysis, and competitive landscapes. For a condition such as Ataxia Telangiectasia, a DelveInsight report would provide:
• Historical and forecasted incidence/prevalence of Ataxia Telangiectasia across key geographies
• Key drivers of market growth and unmet needs in the disease area
• A detailed view of the clinical pipeline (including eDSP and competing therapies)
• Market opportunity sizing and segmentation (by geography, patient sub type, treatment stage)
• Competitive landscape and possible regulatory / reimbursement scenarios

By combining the clinical milestone from Quince with DelveInsight's structured market intelligence, stakeholders can evaluate how this trial result might influence market entry timelines, commercial potential, patient pool size, and revenue projections. In short, the DelveInsight report acts as a strategic tool to translate clinical developments into business insights and planning.

Discover actionable intelligence on Ataxia Telangiectasia market size, trends, and long-term forecasts through 2034 for informed planning.
https://www.delveinsight.com/sample-request/ataxia-telangiectasia-at-market?utm_source=openpr&utm_medium=pressrelease&utm_campaign=gpr

Media Contact
Company Name: DelveInsight Business Research LLP
Contact Person: Gaurav Bora
Email: info@delveinsight.com
City: Albany
State: New York
Country: United States
Website: https://www.delveinsight.com

About DelveInsight
DelveInsight is a leading Business Consultant, and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.
It also offers Healthcare Consulting Services, which benefits in market analysis to accelerate the business growth and overcome challenges with a practical approach.

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