Post-Operative Pain Therapeutics Market Soars: Innovative Treatments Redefining Recovery in 2025 | Top key players - Trevena Inc., Heron Therapeutics, Bayer AG.

Market Overview:

The Post-Operative Pain Therapeutics Market is estimated to reach at a CAGR of 5.2% during the forecast period (2024-2031). The Market is growing due to the rising number of surgical procedures worldwide and increased demand for effective pain management therapies. According to DataM Intelligence

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The Post-operative Pain Therapeutics Market encompasses drugs, devices, and treatment solutions designed to manage and alleviate pain following surgical procedures. It includes opioids, non-opioid analgesics, regional anesthetics, and novel therapies aimed at improving patient recovery, reducing complications, and enhancing post-surgery comfort. The market growth is driven by rising surgical procedures and demand for effective pain management.

Industry Recent Developments: United States

✅ November 2025: Ongoing Phase 2b registration trial by Allay Therapeutics for ATX101, a product providing sustained analgesia post total knee arthroplasty, aiming for FDA NDA submission if successful.

✅ October 2025: AtriCure launched its cryoXT device in the U.S., using cryoablation technology to reduce post-operative pain following amputations, cleared by the FDA.

✅ September 2025: Johnson & Johnson announced a $2 billion investment to expand manufacturing at FUJIFILM's Holly Springs site in North Carolina to support advanced medicines production focused on postoperative pain therapeutics.

Industry Recent Developments: Japan

✅ November 2025: Japan's topical pain management therapeutics market is growing, driven by demand for non-systemic pain relief therapies such as topical NSAIDs, with major players like Hisamitsu Pharmaceutical and Rohto leading the segment.

✅ October 2025: Continued rise in demand for post-operative pain medications tied to increasing age-related surgeries, with innovations focusing on safer, lower-dose drug formulations adapting to the aging population.

✅ September 2025: Growth in intrathecal drugs for chronic back pain and muscle spasticity management, with a push towards novel non-opioid, non-steroidal drugs to address side effects and improve safety and efficacy.

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FDA / Regulatory Approvals in 2025:

✅ In January 2025, the suzetrigine (brand name Journavx) oral tablet was approved by the U.S. Food & Drug Administration (FDA) for moderate‐to‐severe acute pain (including post‐surgical/acute settings). This marks the first approval of a new non‐opioid analgesic class in over 20 years.

✅ Regulatory frameworks and guidelines in 2025 increasingly emphasise alternatives to opioids and multimodal analgesia approaches - this regulatory shift is supporting novel therapies in the post‐operative pain space.

✅ Meanwhile, pipeline products in the post‐operative pain domain (for example a new fast‐acting formulation of meloxicam designated MR‐107A‐02 by Viatris Inc., and a candidate by Tris Pharma Inc.) announced positive Phase III results with the intention to submit NDAs later in 2025.

Mergers, Acquisitions & Licensing Transactions in 2025:

✅ In May 2025, Eli Lilly and Company announced the acquisition of SiteOne Therapeutics in a deal worth up to US $1 billion for rights to its experimental non‐opioid pain therapy STC‐004 (a Nav1.8 inhibitor), signalling strategic interest in the post‐operative pain therapeutics space.

✅ Although broader pharma/biotech M&A data show many deals in 2025, dedicated acquisitions purely in the post‐operative pain niche remain relatively limited - the Lilly/SiteOne deal stands out as a major move.

Major Key Players:

Mallinckrodt Pharmaceuticals
Trevena Inc.
Heron Therapeutics
Teva Pharmaceutical Industries Ltd.
Camarus
Bayer AG
Pacira BioSciences Inc.
Pfizer Inc.
Novartis AG
Hyloris Pharmaceuticals SA
Eli Lilly & Company.

Segments Covered in the Post-operative Pain Therapeutics Market:

By Drug Type: Opioids, NSAIDs, Glucocorticoids, Local Anesthetics, Tricyclic Antidepressants, Antiepileptic drugs, Others.

By Route of Administration: Oral, Intravenous, Intramuscular, Others.

By Type of Pain: Neuropathic Pain, Nociceptive Pain.

By Distribution Channel: Hospital Pharmacies, Retail Pharmacies, Online Pharmacies, E-commerce, Others.

Regional Analysis for Post-operative Pain Therapeutics Market:

⇥ North America (U.S., Canada, Mexico)

⇥ Europe (U.K., Italy, Germany, Russia, France, Spain, The Netherlands and Rest of Europe)

⇥ Asia-Pacific (India, Japan, China, South Korea, Australia, Indonesia Rest of Asia Pacific)

⇥ South America (Colombia, Brazil, Argentina, Rest of South America)

⇥ Middle East & Africa (Saudi Arabia, U.A.E., South Africa, Rest of Middle East & Africa)

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Chapter Outline:

⏩ Market Overview: It contains five chapters, as well as information about the research scope, major manufacturers covered, market segments, Post-operative Pain Therapeutics market segments, study objectives, and years considered.

⏩ Market Landscape: The competition in the Global Post-operative Pain Therapeutics Market is evaluated here in terms of value, turnover, revenues, and market share by organization, as well as market rate, competitive landscape, and recent developments, transaction, growth, sale, and market shares of top companies.

⏩ Companies Profiles: The global Post-operative Pain Therapeutics market's leading players are studied based on sales, main products, gross profit margin, revenue, price, and growth production.

⏩ Market Outlook by Region: The report goes through gross margin, sales, income, supply, market share, CAGR, and market size by region in this segment. North America, Europe, Asia Pacific, Middle East & Africa, and South America are among the regions and countries studied in depth in this study.

⏩ Market Segments: It contains the deep research study which interprets how different end-user/application/type segments contribute to the Post-operative Pain Therapeutics Market.

⏩ Market Forecast: Production Side: In this part of the report, the authors have focused on production and production value forecast, key producers forecast, and production and production value forecast by type.

⏩ Research Findings: This section of the report showcases the findings and analysis of the report.

⏩ Conclusion: This portion of the report is the last section of the report where the conclusion of the research study is provided.

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Frequently asked questions:

➠ What is the global sales value, production value, consumption value, import and export of Post-operative Pain Therapeutics market?

➠ Who are the global key manufacturers of the Post-operative Pain Therapeutics Industry? How is their operating situation (capacity, production, sales, price, cost, gross, and revenue)?

➠ What are the Post-operative Pain Therapeutics market opportunities and threats faced by the vendors in the global Post-operative Pain Therapeutics Industry?

➠ Which application/end-user or product type may seek incremental growth prospects? What is the market share of each type and application?

➠ What focused approach and constraints are holding the Post-operative Pain Therapeutics market?

➠ What are the different sales, marketing, and distribution channels in the global industry?

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