Press release
United States Plasmid Purification Market to hit US$ 5.46 billion by 2033: Industry Developments, Future Growth, Share & Industry Insights
Plasmid Purification Market
According to DataM Intelligence Comprehensive Report has released its latest report on the "Plasmid Purification Market Size 2025," providing a detailed analysis of market trends, key growth drivers, competitive landscape, and regional insights. The report includes market size (value and volume), CAGR projections, and emerging opportunities that help businesses identify growth areas and build effective strategies. Backed by data-driven insights and future outlook, this study serves as a valuable resource for companies looking to stay competitive and capitalize on market potential.
United States: Recent Industry Developments
✅ October 2025: Thermo Fisher Scientific launched an automated plasmid purification system aimed at enhancing scalability for gene therapy manufacturing.
✅ September 2025: Aldevron expanded its GMP plasmid production capabilities to support increased demand from mRNA vaccine manufacturers.
✅ August 2025: Research labs adopted next-gen chromatography techniques to improve plasmid purity and yield efficiency.
Japan: Recent Industry Developments
✅ October 2025: Takara Bio introduced high-throughput plasmid purification kits optimized for synthetic biology applications.
✅ September 2025: Fujifilm expanded bioprocessing facilities focusing on plasmid DNA production for next-generation therapeutics.
✅ August 2025: Collaborative R&D projects between Japanese biotech firms and academic institutions advanced cost-effective purification technologies.
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Major Key Player:
Merck KGaA, QIAGEN, Thermo Fisher Scientific, Inc., Takara Bio Inc., Promega Corporation, Zymo Research Corporation, MP BIOMEDICALS, New England Biolabs, MCLAB, Applied Biological Materials Inc
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Latest M&A
In February 2025, Thermo Fisher Scientific acquired Solventum's Purification and Filtration business in the U.S. for USD 4.1 billion, significantly expanding its plasmid DNA purification and bioprocessing portfolio.
Merck (Merck KGaA) completed a $3.4 billion acquisition of SpringWorks Therapeutics in 2025, supporting expanded biologics manufacturing capabilities impacting plasmid purification supply chains. Merck also acquired JSR Life Sciences' chromatography business in 2025 to strengthen downstream purification tools.
Moderate consolidation with biotech CDMOs focusing on scalable, GMP-grade plasmid production and purification to meet gene therapy demand.
Key Segments:
By Offering
Products - 65%: dominant due to high demand for reagents, kits, and consumables.
Services - 35%: growing segment offering specialized support like custom gene editing and analysis.
By Grade
Molecular Grade - 55%: widely used for basic research and routine cloning applications.
Transfection Grade - 40%: essential for gene delivery and editing workflows.
By Application
Cloning & Protein Expression - 50%: largest use for producing recombinant proteins and gene function studies.
Transfection & Gene Editing - 35%: expanding rapidly with CRISPR and other genome engineering tools.
By End-User
Pharmaceutical & Biotechnology Companies - 60%: primary consumers for drug development and biologics.
Academic & Research Institutes - 30%: key users for fundamental and applied research.
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GMP-grade Plasmid DNA Manufacturing and Quality Control
High-quality GMP-grade plasmid DNA manufacturing ensures stringent quality control to meet therapeutic standards and regulatory requirements. This is critical for producing reliable materials used in advanced gene therapies and vaccines.
Gene Therapy and Cell-based Therapy Applications
Gene and cell-based therapies rely on cutting-edge manufacturing processes to deliver targeted treatments for genetic and degenerative diseases. These therapies are transforming personalized medicine by enabling precise disease intervention.
mRNA Vaccine Production and Bioprocessing Workflows
mRNA vaccine production involves complex bioprocessing workflows designed to optimize yield, purity, and stability. Streamlined processes are key to meeting global demand, especially during pandemics.
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Latest FDA Approvals & Reimbursement
FDA regulatory approvals continue to expand for plasmid DNA manufacturing platforms supporting gene therapies and vaccines, with emphasis on GMP compliance and stringent quality controls.
US Medicare and Medicaid provide reimbursement frameworks for gene therapies utilizing plasmid DNA, easing market access and commercial viability for advanced therapeutics.
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DataM Intelligence is a Market Research and Consulting firm that provides end-to-end business solutions to organizations from Research to Consulting. We, at DataM Intelligence, leverage our top trademark trends, insights and developments to emancipate swift and astute solutions to clients like you. We encompass a multitude of syndicate reports and customized reports with a robust methodology.
Our research database features countless statistics and in-depth analyses across a wide range of 6300+ reports in 40+ domains creating business solutions for more than 200+ companies across 50+ countries; catering to the key business research needs that influence the growth trajectory of our vast clientele.
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