United States Biopharmaceutical Fermentation Systems Market 2025 | Growth Drivers, Key Players & Investment Opportunities

Market Size and Growth

The global biopharmaceutical fermentation systems market is estimated to reach at a high CAGR of 5,9% during the forecast period 2024-2031.

Key Development:

United States: Recent Industry Developments

✅ In October 2025, Rentschler Biopharma SE announced expansion of its regional services in Japan and South Korea, reinforcing its global CDMO footprint and highlighting accelerated cell-line development and biologics manufacturing capabilities in the US-influenced region.

✅ In June 2025, the US biopharmaceutical fermentation systems market gained momentum, reflecting rising demand for advanced bioreactor platforms and biologics manufacturing infrastructure.

✅ In February 2025, Liberation Labs secured USD 50.5 million to complete a 600,000-liter precision fermentation biomanufacturing facility in Indiana, designed to scale microbial-based biologic and biopharmaceutical production.

✅ In January 2025, Seppic Inc. inaugurated a dedicated fermentation biotechnology R&D laboratory at Air Liquide's Innovation Campus in Delaware, enhancing its capability to develop fermentation-derived bio-ingredients for health and biopharmaceutical sectors.

Japan: Recent Industry Developments

✅ In April 2025, Kyowa Kirin Co., Ltd. completed construction of a new drug-substance manufacturing facility (HB7 building) at its Takasaki plant in Gunma Prefecture, equipped with GMP-compliant pilot and early-phase manufacturing lines for biopharmaceuticals.

✅ In April 2025, AGC Biologics announced the installation of two 5,000 L single-use bioreactors at its new Yokohama facility, positioning it among the most advanced mammalian-cell biomanufacturing sites in Japan with GMP operations targeted for 2027.

✅ In March 2025, Fermelanta closed a ¥2 billion Series A funding round to scale microbial fermentation of rare natural compounds, with a pilot plant (~3,000 L bioreactor) scheduled for completion in 2026 underscoring Japan's push into synthetic-biology enabled biomanufacturing.

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Key Players:

=> Corning, Inc., Thermo Fisher Scientific Inc., Danaher Corporation, Sartorius StedimBiotech, Merck KGaA (Merck Millipore), Eppendorf AG, 3M Company., Nova Biomedicals, Lonza, and Repligen Corporation.

Recent Mergers and Acquisitions

United States: Recent M&A Developments

✅ In September 2025, Roche entered into a definitive merger agreement to acquire 89bio for an estimated total value of up to approximately US $3.5 billion, strengthening its biologics and metabolic‐disease pipeline.

✅ In July 2025, BioMarin Pharmaceutical Inc. completed the acquisition of Inozyme Pharma, Inc. for roughly US $270 million in cash, adding an enzyme‐replacement therapy candidate to its portfolio.

✅ In March 2025, Bristol Myers Squibb (BMS) acquired 2seventy bio for about US $286 million to gain full control of its cell‐therapy manufacturing and commercial assets.

✅ In January 2025, GSK announced the acquisition of US‐based biotech IDRx for up to US $1.15 billion, in a move to boost its pipeline in gastrointestinal stromal tumour therapies.

Japan: Recent M&A Developments

✅ In May 2025, Shionogi & Co., Ltd. announced a company split via absorption of the pharmaceutical business of Japan Tobacco Inc. and the acquisition of all issued shares of Akros Pharma Inc. (a U.S. subsidiary) to strengthen its global manufacturing and drug‐substance capabilities.

✅ In February 2025, Bain Capital agreed to acquire Mitsubishi Tanabe Pharma Corporation from Mitsubishi Chemical Group Corporation in a deal valued at ~¥510 billion (≈US $3.3 billion), with the aim of accelerating drug development and manufacturing in Japan.

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Key Segments:

> By Product
Upstream products include raw materials, media, and reagents used in the initial stages of biopharmaceutical production. Downstream products involve purification, formulation, and finishing solutions critical for final product quality and safety. Both product types are essential for efficient, high-yield bioprocessing.

> By Application
Monoclonal antibodies, recombinant proteins, antibiotics, and probiotics represent the primary applications, catering to therapeutic, research, and commercial needs. These applications drive demand for specialized upstream and downstream solutions. Other niche applications include enzyme production and vaccine development.

> By End-User
Biopharmaceutical companies are the largest consumers, using these products for large-scale drug manufacturing. Contract manufacturing organizations (CMOs), contract research organizations (CROs), and academic research institutes rely on these solutions for research and pilot-scale production. The food industry uses probiotics and fermentation products in functional foods.

By Region

North America leads the market due to advanced biopharma infrastructure, research funding, and high adoption of upstream and downstream technologies.

Europe shows steady growth, driven by strong pharmaceutical and biotech ecosystems.

South America is a growing market, particularly in Brazil and Argentina for biopharma and food applications.

Middle East & Africa are emerging markets, with adoption mainly in research institutes and pilot-scale production.

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