Press release
Persistent Epithelial Defect Market: Regenerative and Biologic Therapies Drive Growth to 2034
Persistent Epithelial Defect Market
Rising incidence of corneal surface injuries, adoption of regenerative eye therapies, and innovation in biologic eye drops are driving steady expansion of the persistent epithelial defect (PED) market worldwide.
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Introduction
The Persistent Epithelial Defect (PED) Market is gaining clinical and commercial importance as ophthalmology embraces regenerative medicine, biologic formulations, and advanced wound-healing technologies.
Valued at USD 210 million in 2024, the market is projected to reach USD 420 million by 2034, expanding at a CAGR of 7.1% over the forecast period.
PED refers to a failure of the corneal epithelium to re-epithelialize after injury or surgery, often caused by neurotrophic keratopathy, dry-eye syndrome, or post-LASIK complications. Recent advancements in growth-factor therapies and stem-cell-based solutions are enhancing healing outcomes and reducing vision loss risk.
Key Players in the Market
The PED market comprises ophthalmic leaders and biotech start-ups focused on corneal regeneration and surface repair.
Notable players include:
• Dompé Farmaceutici S.p.A.
• Regeneron Pharmaceuticals Inc.
• Novartis AG (Alcon Division)
• Johnson & Johnson Vision Care Inc.
• Santen Pharmaceutical Co. Ltd.
• Allergan plc (AbbVie Inc.)
• Sun Pharma Industries Ltd.
• KeraMed Inc.
• MIMETAS B.V.
• Horus Pharma
These companies are investing in nerve-growth factor (NGF) treatments, amniotic membrane transplants, and biocompatible drug-delivery systems to accelerate corneal healing and prevent recurrence.
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Key Events in the Last Five Years
• 2020-2021: Clinical adoption of Oxervate (cenegermin-bkbj) by Dompé marked a turning point in PED management, introducing the first NGF-based therapy.
• 2022: Expansion of biologic eye drops and amniotic membrane grafts in ophthalmic clinics across Europe and Asia.
• 2023: AI-enabled corneal topography systems enhanced diagnostic accuracy for neurotrophic and traumatic PED cases.
• 2024: Start-ups in Japan and the U.S. launched novel stem-cell sheet technologies and nanogel-based corneal patches.
Market Growth Rate
According to Exactitude Consultancy, the PED market is expected to grow at a CAGR of 7.1% from 2025 to 2034, driven by:
• Increased prevalence of ocular surface diseases and post-surgical epithelial defects.
• Emerging biologic and regenerative treatments offering superior efficacy.
• Wider availability of AI-based diagnostic tools and home-care monitoring devices.
• Supportive reimbursement policies for advanced ophthalmic products in developed regions.
Market Segments and Growth Analysis
The PED market is segmented by therapy type, disease cause, and region.
By Therapy Type:
• Biologic Eye Drops (NGF, EGF, and Serum-Derived Formulations)
• Amniotic Membrane Transplants and Corneal Bandages
• Autologous Serum Eye Drops and Platelet-Rich Plasma (PRP)
• Stem-Cell and Gene Therapies
• Supportive Medications (Antibiotics, Lubricants, Corticosteroids)
By Disease Cause:
• Neurotrophic Keratopathy
• Dry Eye Disease
• Post-Surgical and Traumatic Defects
• Infectious and Autoimmune Etiologies
By Region:
• North America: Leads in adoption of NGF therapies and corneal implants.
• Europe: Strong clinical trials network for regenerative ophthalmology.
• Asia Pacific: Rising demand for affordable serum therapies in India, Japan, and China.
• Latin America & MEA: Gradual uptake of autologous formulations and AI screening tools.
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Key Market Drivers
1. Regenerative and Biologic Innovation:
NGF-based treatments and stem-cell transplants are restoring epithelial integrity in refractory patients.
2. AI and Digital Diagnostics:
Machine-learning corneal maps enable personalized therapy selection and healing prediction.
3. Rising Surgical Volume:
Increasing LASIK and cataract procedures contribute to higher post-operative PED risk.
4. Expanding Access to Ophthalmic Care:
Tele-ophthalmology and home delivery of biologic eye drops support long-term adherence.
Recent Developments
• 2023: Dompé Farmaceutici expanded Oxervate availability to Latin America and Asia Pacific.
• 2024: Novartis launched a clinical trial for its EGF-enhanced eye drop platform in Europe.
• 2024: Allergan (AbbVie) introduced a next-generation lubricant with bio-adhesive polymers for chronic corneal defects.
• 2024: Japanese research teams announced pre-clinical success for CRISPR-edited epithelial cell therapies for PED.
Expert Insight
"Persistent epithelial defects are among the most challenging corneal conditions. With the integration of growth factor biologics and AI-assisted monitoring, we are now seeing healing rates that were unimaginable a decade ago,"
- Dr. Laura Mendez, Corneal Specialist, Bascom Palmer Eye Institute.
Conclusion
The Persistent Epithelial Defect Market is transitioning from palliative care to curative and regenerative approaches.
As biologic therapies and stem-cell advancements gain regulatory traction, patients worldwide can expect faster recovery and fewer vision loss complications. Combined with AI-powered diagnostics and tele-ophthalmology, the PED market is poised for strong, sustainable growth through 2034.
This report is also available in the following languages : Japanese (持続性上皮欠損市場), Korean (지속성 상피 결손 시장), Chinese (持续性上皮缺陷市场), French (Marché des défauts épithéliaux persistants), German (Markt für persistierende Epitheldefekte), and Italian (Mercato dei difetti epiteliali persistenti), etc.
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