Protein Expression & Purification Services Market Set to Reach $8.95 Billion by 2033 | Exclusive Data Like Latest M & A, Regulatory Approvals, FDA Approvals, Latest Investments, Reimbursements 2025

The global protein expression & purification services market reached US$ 3.96 billion in 2023, with a rise to US$ 4.30 billion in 2024, and is expected to reach US$ 8.95 billion by 2033, growing at a CAGR of 9.6% during the forecast period 2025-2033.

DataM Intelligence has published a new research report on "Protein Expression & Purification Services Market Size 2025". The report explores comprehensive and insightful Information about various key factors like Regional Growth, Segmentation, CAGR, Business Revenue Status of Top Key Players and Drivers. The purpose of this report is to provide a telescopic view of the current market size by value and volume, opportunities, and development status.

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1) Mergers & Acquisitions:

The market is seeing continued consolidation as major life science players expand their bioprocessing portfolios. Thermo Fisher, Merck, and Cytiva have made strategic acquisitions in purification and filtration technologies to strengthen their integrated biologics service chains. This M&A momentum highlights growing demand for end-to-end expression and purification capabilities within CDMOs and research organizations.

2) Regulatory & FDA Approvals:

Regulatory activity around biologics and biosimilars is increasing, with the FDA streamlining approval pathways to boost access and reduce time-to-market. This trend drives demand for high-quality protein expression and purification services that comply with GMP standards. Service providers are aligning capabilities with FDA and EMA expectations to support clients' biologic submissions and clinical manufacturing.

3) Investments & Funding Trends:

Investments in protein expression and purification infrastructure have surged, particularly within CDMOs expanding global capacity for recombinant protein production. Capital is flowing toward advanced purification systems, continuous bioprocessing, and single-use technologies. Strategic partnerships and private equity funding are fueling innovation and scalability in this service space.

4) Reimbursement Landscape:

While reimbursement doesn't directly apply to service providers, it indirectly impacts market demand. Broader reimbursement coverage for biologics and biosimilars encourages greater R&D and manufacturing activity, leading to increased outsourcing of protein production and purification tasks. Policy support for biosimilars, especially in the U.S. and Europe, is expected to further accelerate service utilization.

Key Players:

Thermo Fisher Scientific Inc., GenScript, Merck KGaA, Creative Biolabs, Bhat Bio-tech India Private Limited, Charles River Laboratories, Agilent Technologies, Inc., Aragen Life Sciences Ltd., Sino Biological, Inc., Domainex, among others.

Key Development:

United States: Recent Industry Developments

✅ In September 2025, Thermo Fisher Scientific Inc. expanded its StrepTag® Protein Expression and Purification Platform in Massachusetts, integrating automated chromatography and AI-based process analytics to enhance recombinant protein yield and purity.

✅ In August 2025, GenScript Biotech USA launched a next-generation protein expression service leveraging CRISPR-optimized mammalian cell lines for faster and scalable therapeutic protein production. The new system reduces turnaround time by nearly 40%.

✅ In July 2025, Agilent Technologies Inc. introduced a modular purification workstation combining HPLC and FPLC systems for academic and biopharma customers, streamlining workflows for antibody and enzyme purification.

✅ In May 2025, Sartorius Stedim North America announced the opening of a new Protein Services Center in California, offering end-to-end protein expression, purification, and analytical characterization services for biologics developers.

Japan: Recent Industry Developments

✅ In September 2025, Takara Bio Inc. launched an integrated insect cell protein expression service based on the Baculovirus Expression Vector System (BEVS), targeting research and vaccine development applications.

✅ In August 2025, FUJIFILM Diosynth Biotechnologies expanded its Kyoto facility to include single-use bioreactors and continuous chromatography for improved protein purification scalability.

✅ In June 2025, Kyowa Kirin Co., Ltd. announced advancements in cell-free protein synthesis technology, enabling the expression of difficult-to-fold membrane proteins for drug discovery.

✅ In May 2025, JNC Corporation developed a nanofiber membrane purification platform for high-throughput separation of recombinant proteins, reducing process costs and energy usage.

Growth Forecast Projected:

The Global Protein Expression & Purification Services Market is anticipated to rise at a considerable rate during the forecast period, between 2025 and 2032. In 2024, the market is growing at a steady rate, and with the rising adoption of strategies by key players, the market is expected to rise over the projected horizon.

Research Process:

Both primary and secondary data sources have been used in the global Protein Expression & Purification Services Market research report. During the research process, a wide range of industry-affecting factors are examined, including governmental regulations, market conditions, competitive levels, historical data, market situation, technological advancements, upcoming developments, in related businesses, as well as market volatility, prospects, potential barriers, and challenges.

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Key Segments:

By Service Type:
Protein Expression Services | Protein Purification Services

By Protein Type:
Natural Proteins | Synthetic Proteins

By Application:
Research and Development | Diagnostics | Biotechnological Product Manufacturing | Agriculture | Others

By End-User:
Pharmaceutical & Biotechnology Companies | Contract Development & Manufacturing Organizations (CDMOs) | Diagnostic Laboratories & Clinical Research Centers | Others

Regional Analysis for Market:

⇥ North America (U.S., Canada, Mexico)

⇥ Europe (U.K., Italy, Germany, Russia, France, Spain, The Netherlands and Rest of Europe)

⇥ Asia-Pacific (India, Japan, China, South Korea, Australia, Indonesia Rest of Asia Pacific)

⇥ South America (Colombia, Brazil, Argentina, Rest of South America)

⇥ Middle East & Africa (Saudi Arabia, U.A.E., South Africa, Rest of Middle East & Africa)

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