Diabetes: Clinical Insights, Key Companies, Therapeutic Assessment, Emerging Therapies, Treatment Algorithm, and Pipeline Analysis | Featuring vTv Therapeutics, Eli Lilly and Company, Sciwind Bioscien

DelveInsight's, "Diabetes - Pipeline Insight, 2025" report provides comprehensive insights about 200+ companies and 200+ pipeline drugs in Diabetes pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
According to DelveInsight's analysis, the Diabetes pipeline features over 200 leading companies actively engaged in the development of 200+ innovative therapies aimed at improving Diabetes treatment.

Diabetes Overview:

Diabetes is a chronic metabolic disorder characterized by persistently high blood glucose levels due to the body's inability to produce enough insulin or effectively use it. Insulin, a key hormone that regulates blood sugar, plays a vital role in maintaining energy balance. The condition is mainly classified into two types: Type 1 diabetes, an autoimmune disease in which the immune system destroys insulin-producing beta cells in the pancreas, and Type 2 diabetes, the more common form, typically associated with insulin resistance and influenced by factors such as obesity, poor diet, and physical inactivity. Less common forms include gestational diabetes, which develops during pregnancy, and rare types such as Maturity-Onset Diabetes of the Young (MODY) and Latent Autoimmune Diabetes in Adults (LADA).

Symptoms vary based on type and severity but often include excessive thirst, frequent urination, extreme hunger, unintended weight loss, fatigue, and blurred vision - all linked to fluctuating blood sugar levels. People with Type 2 diabetes may also experience slow-healing wounds, recurrent infections, and numbness or tingling in the extremities due to nerve damage.

The disease's underlying mechanism involves disrupted blood glucose regulation caused by insulin deficiency or resistance. In Type 1 diabetes, autoimmune destruction of pancreatic beta cells leads to little or no insulin production, preventing glucose from entering cells and resulting in elevated blood sugar levels. In Type 2 diabetes, the body's cells become resistant to insulin's effects, and the pancreas fails to produce sufficient insulin to compensate, leading to chronic hyperglycemia. Prolonged high blood sugar can damage blood vessels, nerves, and vital organs, contributing to complications such as cardiovascular disease, neuropathy, retinopathy, and nephropathy. The development of diabetes is influenced by a combination of genetic factors, environmental triggers, and lifestyle habits.

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"Diabetes Pipeline Insight 2025" report by DelveInsight provides a comprehensive analysis of the ongoing clinical development activities and growth prospects across the Diabetes Therapeutics Market.

Key Takeaways from the Diabetes Pipeline Report

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DelveInsight's Diabetes pipeline report highlights a dynamic landscape featuring over 200 active companies developing 200+ innovative therapies aimed at improving diabetes management.

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In February 2025, the FDA approved Merilog, the first short-acting insulin biosimilar to Novolog, developed by Viatris. This milestone follows the approval of two long-acting insulin biosimilars in 2021, marking continued progress in biosimilar insulin availability.

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On January 28, 2025, the FDA also approved Ozempic (Novo Nordisk), a GLP-1 receptor agonist, for slowing the progression of chronic kidney disease (CKD) and reducing mortality in patients with Type 2 diabetes and CKD-making it the first GLP-1 therapy to receive approval for this indication.

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Leading pharmaceutical companies such as vTv Therapeutics, Eli Lilly and Company, Sciwind Biosciences, AstraZeneca, Neurodon, Regor Therapeutics, Abarceo Pharma, Chong Kun Dang Pharmaceutical, Roche, Rivus Pharmaceuticals, and Kallyope Inc are actively advancing their diabetes drug portfolios to reshape the treatment landscape.

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Promising pipeline candidates currently in various stages of development include K-833, XW014, HU6, CT-388, LY-3209590, Cadisegliatin, and others.

Diabetes Pipeline Analysis

The report provides insights into:

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The report provides detailed insights into the key companies that are developing therapies in the Diabetes Market.

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The report also evaluates different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Diabetes treatment.

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It analyzes the key companies involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.

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It navigates the emerging drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.

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Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement, and financing details for future advancement of the Diabetes market.

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Diabetes Emerging Drugs

Cadisegliatin - vTv Therapeutics

Cadisegliatin (TTP399), developed by vTv Therapeutics, is an innovative oral liver-selective glucokinase activator designed to improve glucose control in individuals with Type 1 diabetes (T1D). Intended as an adjunct to insulin therapy, it works by enhancing glucose uptake and glycogen synthesis in the liver, operating independently of insulin action. By specifically targeting hepatic glucose metabolism, cadisegliatin offers a promising approach to addressing unmet needs in diabetes management. The drug is currently in Phase III clinical trials for the treatment of diabetes.

LY3209590 - Eli Lilly and Company

Insulin efsitora alfa (LY3209590) is a next-generation, long-acting basal insulin analog developed for once-weekly dosing. This fusion protein combines a modified single-chain insulin with a human IgG2 Fc fragment, optimizing its duration and stability. Administered subcutaneously, efsitora is designed to deliver a low peak-to-trough insulin ratio, ensuring consistent glucose control and minimizing fluctuations throughout the week. The therapy is currently in Phase III clinical development for adult patients with Type 1 and Type 2 diabetes.

CT-388 - Roche

CT-388 is a once-weekly injectable candidate being developed for the treatment of obesity and Type 2 diabetes (T2D). It functions as a dual agonist of the GLP-1 and GIP receptors, engineered to activate these receptors with strong efficacy while limiting -arrestin recruitment. This mechanism helps reduce receptor internalization and desensitization, potentially enhancing and prolonging its therapeutic action. CT-388 is currently in Phase II clinical trials for Type 2 Diabetes Mellitus.

Diabetes Companies

More than 200 leading companies are actively engaged in developing therapies for diabetes. Among these, vTv Therapeutics and Eli Lilly and Company have drug candidates in the most advanced phase of development-Phase III clinical trials.

DelveInsight's report covers around 75+ products under different phases of clinical development like

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Late stage products (Phase III)

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Mid-stage products (Phase II)

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Early-stage product (Phase I) along with the details of

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Pre-clinical and Discovery stage candidates

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Discontinued & Inactive candidates

Diabetes pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

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Intravenous

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Subcutaneous

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Oral

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Intramuscular

Diabetes Products have been categorized under various Molecule types such as

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Monoclonal antibody

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Small molecule

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Peptide

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Diabetes Pipeline Therapeutic Assessment

- Diabetes Assessment by Product Type

- Diabetes By Stage

- Diabetes Assessment by Route of Administration

- Diabetes Assessment by Molecule Type

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Table of Content

1. Report Introduction

2. Executive Summary

3. Diabetes Current Treatment Patterns

4. Diabetes - DelveInsight's Analytical Perspective

5. Therapeutic Assessment

6. Diabetes Late-Stage Products (Phase-III)

7. Diabetes Mid-Stage Products (Phase-II)

8. Early Stage Products (Phase-I)

9. Pre-clinical Products and Discovery Stage Products

10. Inactive Products

11. Dormant Products

12. Diabetes Discontinued Products

13. Diabetes Product Profiles

14. Diabetes Key Companies

15. Diabetes Key Products

16. Dormant and Discontinued Products

17. Diabetes Unmet Needs

18. Diabetes Future Perspectives

19. Diabetes Analyst Review

20. Appendix

21. Report Methodology

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About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.

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