Hypertriglyceridemia Clinical, Companies, Therapy Assessment, Therapies, Pipeline| NorthSea Therapeutics, Arrowhead Pharmaceuticals, Zhejiang Doer Biologics, Ionis Pharmaceuticals, GeneCradle, MediciN

DelveInsight's, "Hypertriglyceridemia - Pipeline Insight, 2025" report provides comprehensive insights about 18+ companies and 20+ pipeline drugs in Hypertriglyceridemia pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
DelveInsight's analysis reveals that the Hypertriglyceridemia pipeline includes over 18 leading companies actively engaged in developing 20+ therapeutic candidates. The comprehensive report covers the clinical landscape, company profiles, therapeutic assessments, treatment algorithms, and pipeline insights, featuring key players such as NorthSea Therapeutics, Arrowhead Pharmaceuticals, Zhejiang Doer Biologics, Ionis Pharmaceuticals, GeneCradle, MediciNova, and Regeneron Pharmaceuticals.

Hypertriglyceridemia Overview:

Hypertriglyceridemia is characterized by elevated triglyceride levels in the bloodstream, often associated with an increased risk of cardiovascular disease (CVD) and acute pancreatitis. The condition typically develops due to uncontrolled diabetes, obesity, sedentary lifestyle, or genetic predispositions. Most individuals remain asymptomatic until triglyceride levels rise above 1000-2000 mg/dL, at which point serious complications such as pancreatitis and metabolic disturbances may occur. Management primarily involves lifestyle interventions-including a balanced diet, weight reduction, and regular physical activity-supplemented with pharmacologic options like statins or fibrates when necessary. Addressing underlying risk factors is key to minimizing overall health complications.

Although often without noticeable symptoms, very high triglyceride levels (above 500 mg/dL) markedly increase the risk of acute pancreatitis, which may manifest as severe abdominal pain, nausea, and vomiting. In familial or genetic cases, xanthomas-yellowish fatty deposits around the eyes, elbows, or knees-can occur. Other, less common manifestations include hepatosplenomegaly (enlarged liver and spleen) and lipemia retinalis, a retinal condition affecting vision. Despite its often silent nature, hypertriglyceridemia reflects deeper metabolic dysfunction and substantially raises the risk of cardiovascular complications.

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"Hypertriglyceridemia Pipeline Insight 2025" report by DelveInsight provides a comprehensive analysis of the ongoing clinical development activities and growth prospects across the Hypertriglyceridemia Therapeutics Market.

Key Takeaways from the Hypertriglyceridemia Pipeline Report

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DelveInsight's Hypertriglyceridemia Pipeline Report highlights a dynamic landscape, featuring over 18 active companies developing more than 20 investigational therapies aimed at treating Hypertriglyceridemia.

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In September 2025, Ionis Pharmaceuticals' experimental drug olezarsen (already approved under the brand name Tryngolza for Familial Chylomicronemia Syndrome (FCS)) showed very strong Phase III data in severe hypertriglyceridemia (sHTG) patients: up to ~72% reduction in triglycerides and ~85% reduction in pancreatitis events compared to placebo.

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In December 2024, the FDA approved Tryngolza Registered (olezarsen)-an injectable antisense oligonucleotide targeting apoC-III-as an adjunct to dietary management for adults with familial chylomicronemia syndrome (FCS), marking it as the first FDA-approved therapy for this rare condition.

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Leading companies such as NorthSea Therapeutics, Arrowhead Pharmaceuticals, Zhejiang Doer Biologics, Ionis Pharmaceuticals, GeneCradle, MediciNova, and Regeneron Pharmaceuticals are actively advancing novel candidates to enhance the Hypertriglyceridemia treatment landscape.

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Prominent pipeline therapies currently in development include SEFA-1024, DR10624, GC304, and several others showing strong potential across various clinical stages.

Hypertriglyceridemia Pipeline Analysis

The report provides insights into:

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The report provides detailed insights into the key companies that are developing therapies in the Hypertriglyceridemia Market.

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The report also evaluates different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Hypertriglyceridemia treatment.

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It analyzes the key companies involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.

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It navigates the emerging drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.

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Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement, and financing details for future advancement of the Hypertriglyceridemia market.

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Hypertriglyceridemia Emerging Drugs

SEFA-1024 - NorthSea Therapeutics

SEFA-1024 is an oral, semi-synthetic derivative of eicosapentaenoic acid engineered to act primarily on the gut and liver. It is under development for severe hypertriglyceridemia (sHTG)-a condition associated with an increased risk of acute pancreatitis and potentially cardiovascular disease.

Existing therapies often fail to adequately control triglycerides (TG), non-HDL cholesterol, and glucose levels, highlighting a substantial unmet medical need. Backed by strong preclinical results in a human hypertriglyceridemia model, SEFA-1024 demonstrates encouraging potential to fill this therapeutic gap. The candidate is currently being evaluated in Phase II clinical trials for hypertriglyceridemia.

DR10624 - Doer Biologics

DR10624 is a first-in-class, long-acting tri-agonist that concurrently activates FGF21R, GLP-1R, and the glucagon receptor (GCGR). Developed using Doer Biologics' proprietary MultipleBody platform, it is designed to deliver balanced therapeutic effects across several key metabolic pathways.

Preclinical studies have demonstrated that DR10624 can substantially reduce body weight, lower triglyceride levels, improve overall lipid profiles, and support liver function. The candidate is currently in Phase II clinical trials for the treatment of severe hypertriglyceridemia (sHTG).

Hypertriglyceridemia Companies

Approximately 18 or more leading companies are actively engaged in developing therapies for Hypertriglyceridemia. Among these, NorthSea Therapeutics stands out, with its drug candidate progressing to the most advanced development stage-Phase II clinical trials.

DelveInsight's report covers around 75+ products under different phases of clinical development like

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Late stage products (Phase III)

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Mid-stage products (Phase II)

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Early-stage product (Phase I) along with the details of

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Pre-clinical and Discovery stage candidates

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Discontinued & Inactive candidates

Hypertriglyceridemia pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

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Intravenous

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Subcutaneous

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Oral

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Intramuscular

Hypertriglyceridemia Products have been categorized under various Molecule types such as

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Monoclonal antibody

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Small molecule

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Peptide

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Hypertriglyceridemia Pipeline Therapeutic Assessment

- Hypertriglyceridemia Assessment by Product Type

- Hypertriglyceridemia By Stage

- Hypertriglyceridemia Assessment by Route of Administration

- Hypertriglyceridemia Assessment by Molecule Type

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Table of Content

1. Report Introduction

2. Executive Summary

3. Hypertriglyceridemia Current Treatment Patterns

4. Hypertriglyceridemia - DelveInsight's Analytical Perspective

5. Therapeutic Assessment

6. Hypertriglyceridemia Late-Stage Products (Phase-III)

7. Hypertriglyceridemia Mid-Stage Products (Phase-II)

8. Early Stage Products (Phase-I)

9. Pre-clinical Products and Discovery Stage Products

10. Inactive Products

11. Dormant Products

12. Hypertriglyceridemia Discontinued Products

13. Hypertriglyceridemia Product Profiles

14. Hypertriglyceridemia Key Companies

15. Hypertriglyceridemia Key Products

16. Dormant and Discontinued Products

17. Hypertriglyceridemia Unmet Needs

18. Hypertriglyceridemia Future Perspectives

19. Hypertriglyceridemia Analyst Review

20. Appendix

21. Report Methodology

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About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.

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