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Presbyopia Pipeline 2025: Innovative Clinical Developments by Leading Global Companies, Featuring Visus Therapeutics, Glaukos Corporation, Cellix Bio, Orasis Pharmaceuticals, Cellix Bio

10-16-2025 08:36 PM CET | Associations & Organizations

Press release from: ABNewswire

Presbyopia Pipeline 2025

Presbyopia Pipeline 2025

DelveInsight's, "Presbyopia - Pipeline Insight, 2025" report provides comprehensive insights about 6+ companies and 6+ pipeline drugs in Presbyopia pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
As presbyopia becomes increasingly prevalent worldwide and is associated with comorbidities such as diabetes, cardiovascular disease, and certain cancers, the demand for safer and more effective treatments is rising. According to DelveInsight, the presbyopia pipeline includes over ten pharmaceutical and biotech companies actively developing more than ten therapeutic candidates. These treatments are at various stages of clinical and preclinical development, highlighting significant innovation and commitment to addressing this widespread public health challenge.

DelveInsight's "Presbyopia Pipeline Insight 2025" report offers a comprehensive and strategic analysis of the current R&D landscape. It provides details on clinical trial progress, emerging therapies, mechanisms of action, competitive positioning, and key initiatives from leading companies such as Visus Therapeutics, Glaukos Corporation, Cellix Bio, and Orasis Pharmaceuticals. The report serves as an essential resource for researchers, healthcare investors, and decision-makers seeking insights into the evolving presbyopia therapeutics market and the breakthroughs shaping its future.

Explore the Cutting-Edge Landscape of Presbyopia Drug Development @ https://www.delveinsight.com/report-store/presbyopia-pipeline-insight?utm_source=abnewswire&utm_medium=market&utm_campaign=kpr

Key Takeaways from the Presbyopia Pipeline Report

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DelveInsight's report on the presbyopia pipeline highlights a dynamic landscape, with over ten companies actively developing more than ten therapeutic candidates for presbyopia treatment.

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In July 2025, LENZ partnered with Laboratoires Thea to commercialize LNZ100 in Canada. Its U.S. NDA has been accepted by the FDA, with a target decision date of August 8, 2025. In June 2025, the FDA accepted Tenpoint Therapeutics' NDA for BRIMOCHOL Trademark PF, a fixed-dose combination eye drop (carbachol + brimonidine), with a PDUFA date set for January 28, 2026, and no advisory committee planned.

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Leading companies in the presbyopia space-including Visus Therapeutics, Glaukos Corporation, Cellix Bio, Orasis Pharmaceuticals, and others-are actively exploring new therapies to enhance the treatment landscape. Promising pipeline candidates in various stages of development include LNZ100, GLK-302, and additional investigational treatments.

Presbyopia Overview:

Presbyopia is an age-related vision condition characterized by the gradual decline in the eye's ability to focus on nearby objects, caused by reduced lens flexibility. It typically begins around age 40 and represents one of the most common physiological changes in adults. Symptoms include eye strain, headaches, blurred near vision, and the need to hold reading materials at a greater distance. Extended screen use can exacerbate issues such as delayed focusing and visual fatigue. Reading glasses remain the standard treatment. Although the precise mechanism is still debated, increased lens stiffness is widely accepted as the primary cause. The prevalence of presbyopia in low- and middle-income countries is likely underreported, as most research emphasizes distance vision.

Download the Presbyopia sample report to know in detail about the Presbyopia treatment market [https://www.delveinsight.com/sample-request/presbyopia-pipeline-insight?utm_source=abnewswire&utm_medium=market&utm_campaign=kpr]

Presbyopia Pipeline Analysis

The Presbyopia pipeline insights report 2025, provides insights into:

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Provides comprehensive insights into key companies developing therapies in the Presbyopia Market.

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Categorizes Presbyopia therapeutic companies by development stage: early, mid, and late-stage.

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Highlights major companies involved in targeted therapy development, including both active and inactive (paused/discontinued) projects.

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Reviews emerging Presbyopia drugs under development based on:

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Stage of development

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Presbyopia Route of administration

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Target receptor

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Monotherapy vs. combination therapy

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Presbyopia Mechanism of action

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Molecular type

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Offers detailed analysis of:

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Company-to-company and company-academia collaborations

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Presbyopia Licensing agreements

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Funding and investment activities supporting future Presbyopia market advancement.

Unlock key insights into emerging Presbyopia therapies and market strategies here: https://www.delveinsight.com/report-store/presbyopia-pipeline-insight?utm_source=abnewswire&utm_medium=market&utm_campaign=kpr

Presbyopia Emerging Drugs

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LNZ100: Lenz Therapeutics

LNZ100 is a preservative-free, once-daily eye drop containing aceclidine, a selective muscarinic receptor agonist. It enhances near vision by constricting the pupil, producing a pinhole effect. Unlike other miotic agents, aceclidine minimizes ciliary muscle stimulation, reducing side effects such as brow ache and myopic shift. This makes LNZ100 a well-tolerated, long-acting treatment suitable for a broad range of presbyopia patients, a condition caused by age-related lens stiffening. The FDA has accepted LNZ100's New Drug Application (NDA), and the drug is currently in the registration phase for presbyopia therapy.

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GLK-302: Glaukos Corporation

Glaukos Corporation is developing GLK-302, a sterile topical ophthalmic cream containing pilocarpine for the treatment of presbyopia. Applied to the eyelid, the cream allows pilocarpine to penetrate the skin and reach the eye. As a muscarinic acetylcholine receptor agonist, pilocarpine acts on M1 and M3 receptors, inducing pupillary constriction and increasing depth of focus. This mechanism enhances near vision in presbyopic patients without substantially affecting distance vision. GLK-302 is currently in Phase II clinical trials for presbyopia.

Presbyopia Pipeline Therapeutic Assessment

Presbyopia Assessment by Product Type

- Mono

- Combination

- Mono/Combination

Presbyopia By Stage

- Late-stage products (Phase III)

- Mid-stage products (Phase II)

- Early-stage product (Phase I) along with the details of

- Pre-clinical and Discovery stage candidates

- Discontinued & Inactive candidates

Presbyopia Assessment by Route of Administration

- Oral

- Parenteral

- Intravenous

- Subcutaneous

- Topical

Presbyopia Assessment by Molecule Type

- Recombinant fusion proteins

- Small molecule

- Monoclonal antibody

- Peptide

- Polymer

- Gene therapy

Download sample pages to get an in-depth assessment of the emerging Presbyopia therapies and key Presbyopia companies [https://www.delveinsight.com/sample-request/presbyopia-pipeline-insight?utm_source=abnewswire&utm_medium=market&utm_campaign=kpr]

Table of Contents

1. Report Introduction

2. Executive Summary

3. Presbyopia Current Treatment Patterns

4. Presbyopia - DelveInsight's Analytical Perspective

5. Therapeutic Assessment

6. Presbyopia Late-Stage Products (Phase-III)

7. Presbyopia Mid-Stage Products (Phase-II)

8. Early Stage Products (Phase-I)

9. Pre-clinical Products and Discovery Stage Products

10. Inactive Products

11. Dormant Products

12. Presbyopia Discontinued Products

13. Presbyopia Product Profiles

14. Presbyopia Key Companies

15. Presbyopia Key Products

16. Dormant and Discontinued Products

17. Presbyopia Unmet Needs

18. Presbyopia Future Perspectives

19. Presbyopia Analyst Review

20. Appendix

21. Report Methodology

Request the sample PDF to get detailed insights about the Presbyopia pipeline reports offerings: https://www.delveinsight.com/report-store/presbyopia-pipeline-insight?utm_source=abnewswire&utm_medium=market&utm_campaign=kpr

About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.

Media Contact
Company Name: DelveInsight Business Research LLP
Contact Person: Kritika Rehani
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