Esophageal Cancer Market Outlook 2034: Epidemiology Trends, Emerging Therapies, and Key Regulatory Approvals by DelveInsight | Featuring Roche, Bristol-Myers Squibb, Merck & Co., AstraZeneca, Pfizer,

The Psoriasis market in the 7MM was valued at USD 33,803 million in 2025 and is projected to reach USD 39,239 million by 2034 over the forecast period from 2025 to 2034.
DelveInsight's latest report, "Esophageal Cancer - Market Insights, Epidemiology, and Forecast 2034," provides a comprehensive analysis of the disease landscape, including detailed epidemiological data, evolving market trends, and treatment outlook across the United States, EU4 (Germany, Spain, Italy, and France), the United Kingdom, and Japan.

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Some of the key facts of the Esophageal Cancer Market Report:

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The Esophageal Cancer market is projected to witness substantial growth, registering a notable CAGR during the forecast period (2020-2034).

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In 2023, across the seven major markets (7MM), around 77,000 new cases of esophageal cancer were reported, with Japan leading in incidence, followed by the United States and the United Kingdom. In the U.S., males accounted for nearly 80% of the total cases.

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The treatment pipeline for esophageal cancer features candidates across multiple therapeutic lines, including adjuvant and neoadjuvant settings. Noteworthy emerging therapies such as zanidatamab and bemarituzumab are expected to drive significant market impact in the coming years.

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In 2023, the esophageal cancer market across the 7MM was valued at approximately USD 1 billion, with the U.S. contributing about 40% of the total market share. Japan reported the highest number of diagnosed cases (~26,000) among the 7MM, followed by the U.S.

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By age group, individuals aged 65 years and above constituted the majority of cases, while those under 45 years had the lowest incidence in the U.S. In histology-based segmentation, non-squamous esophageal cancer accounted for roughly 12,500 cases, compared to around 7,300 cases of squamous esophageal cancer in 2023.

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A key regulatory milestone occurred in March 2024, when the U.S. FDA approved TEVIMBRA (tislelizumab) as a monotherapy for adults with unresectable or metastatic esophageal squamous cell carcinoma (ESCC) previously treated with systemic chemotherapy excluding a PD-(L)1 inhibitor.

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Leading companies driving innovation in this space include Roche, Bristol-Myers Squibb, Merck & Co., AstraZeneca, Pfizer, Sanofi, Amgen, and others. Key marketed and emerging therapies include CYRAMZA (ramucirumab), VITRAKVI (larotrectinib), zanidatamab, bemarituzumab, and additional late-stage candidates.

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Overall, the esophageal cancer market is poised for strong expansion, fueled by rising disease prevalence, growing awareness, and the anticipated launch of multiple pipeline therapies expected to transform the treatment landscape.

Esophageal Cancer Overview

Esophageal cancer develops when malignant cells arise in the esophagus - the muscular tube that connects the throat to the stomach and carries food for digestion. The cancer generally begins in the innermost lining of the esophagus and may extend into deeper layers or spread to distant organs through metastasis.

In many cases, symptoms appear only when the tumor has grown large enough to disrupt swallowing or digestion. Difficulty swallowing is the most common symptom, often described as a feeling of food getting stuck in the throat, and may occasionally cause choking. As the tumor enlarges and narrows the esophageal passage, swallowing becomes progressively more painful and challenging.

Diagnosis typically begins with symptom evaluation, followed by clinical examinations, diagnostic imaging, and a biopsy to confirm the presence of cancer cells. Once diagnosed, staging tests help determine the cancer's extent and spread. Although late-stage esophageal cancer is often associated with poor outcomes, early detection can significantly improve the chances of successful treatment.

Since the disease tends to progress silently before symptoms appear, screening in high-risk individuals is essential for timely intervention. Emerging advances in early diagnostic techniques, including liquid biopsy, enhanced endoscopic imaging, and artificial intelligence-based tools, are paving the way for earlier diagnosis and more effective treatment strategies.

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Esophageal Cancer Epidemiology

The epidemiology section provides insights into the historical, current, and forecasted epidemiology trends in the seven major countries (7MM) from 2020 to 2034. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. The epidemiology section also provides a detailed analysis of the diagnosed patient pool and future trends.

Esophageal Cancer Epidemiology Segmentation:

The Esophageal Cancer market report proffers epidemiological analysis for the study period 2020-2034 in the 7MM segmented into:

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Diagnosed Prevalence of Esophageal Cancer in Adults

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Diagnosed Prevalence of Esophageal Cancer in Pediatrics

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Diagnosed Prevalence of Esophageal Cancer by Types

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Diagnosed Prevalence of Esophageal Cancer by Location

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Diagnosed Prevalence of Esophageal Cancer by Severity

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Esophageal Cancer Marketed Drugs

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CYRAMZA (ramucirumab): Eli Lilly and Company

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VITRAKVI (larotrectinib): Bayer

Esophageal Cancer Emerging Drugs

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Zanidatamab: Zymeworks/Jazz Pharmaceuticals

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Bemarituzumab: Amgen

Esophageal Cancer Therapies

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CYRAMZA (ramucirumab), VITRAKVI (larotrectinib), Zanidatamab, Bemarituzumab, and others

Esophageal Cancer Key Companies

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Roche, Bristol-Myers Squibb, Merck & Co, AstraZeneca, Pfizer, Sanofi, Amgen, and others

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Esophageal Cancer Treatment Market

Treatment of Esophageal Cancer involves managing symptoms effectively and addressing underlying health factors, such as diabetes. The first step is achieving proper glycemic control, which can help lower the risk of complications like falls and foot ulcers. Key aspects of treatment include maintaining blood sugar levels, practicing appropriate foot care, and managing pain. Medications commonly used for neuropathic pain include Gabapentin, Pregabalin, Tricyclic Antidepressants (TCAs), Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs), and opioids. Alternative options may include antiseizure drugs such as carbamazepine or lamotrigine.

Patients should collaborate closely with their healthcare providers to create an individualized treatment plan. Because treatment responses can vary, regular follow-ups are crucial for monitoring progress and adjusting therapies as needed. Continuous diabetes management also remains an integral part of care for those with Esophageal Cancer.

Several companies, including Helixmith, Vertex Pharmaceuticals, and AstraZeneca, are actively conducting clinical trials to evaluate new therapeutic options for Esophageal Cancer.

Scope of the Esophageal Cancer Market Report

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Study Period: 2020-2034

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Coverage: 7MM [The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan]

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Key Esophageal Cancer Companies: Roche, Bristol-Myers Squibb, Merck & Co, AstraZeneca, Pfizer, Sanofi, Amgen, and others

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Key Esophageal Cancer Therapies: CYRAMZA (ramucirumab), VITRAKVI (larotrectinib), Zanidatamab, Bemarituzumab, and others

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Esophageal Cancer Therapeutic Assessment: Esophageal Cancer current marketed and Esophageal Cancer emerging therapies

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Esophageal Cancer Market Dynamics: Esophageal Cancer market drivers and Esophageal Cancer market barriers

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Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies

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Esophageal Cancer Unmet Needs, KOL's views, Analyst's views, Esophageal Cancer Market Access and Reimbursement

To know more about Esophageal Cancer companies working in the treatment market, visit @ Esophageal Cancer Clinical Trials and Therapeutic Assessment [https://www.delveinsight.com/sample-request/esophageal-cancer-market?utm_source=abnewswire&utm_medium=market&utm_campaign=kpr]

Table of Contents

1. Esophageal Cancer Market Report Introduction

2. Executive Summary for Esophageal Cancer

3. SWOT analysis of Esophageal Cancer

4. Esophageal Cancer Patient Share (%) Overview at a Glance

5. Esophageal Cancer Market Overview at a Glance

6. Esophageal Cancer Disease Background and Overview

7. Esophageal Cancer Epidemiology and Patient Population

8. Country-Specific Patient Population of Esophageal Cancer

9. Esophageal Cancer Current Treatment and Medical Practices

10. Esophageal Cancer Unmet Needs

11. Esophageal Cancer Emerging Therapies

12. Esophageal Cancer Market Outlook

13. Country-Wise Esophageal Cancer Market Analysis (2020-2034)

14. Esophageal Cancer Market Access and Reimbursement of Therapies

15. Esophageal Cancer Market Drivers

16. Esophageal Cancer Market Barriers

17. Esophageal Cancer Appendix

18. Esophageal Cancer Report Methodology

19. DelveInsight Capabilities

20. Disclaimer

21. About DelveInsight

Related Reports:

Esophageal Cancer Pipeline

"Esophageal Cancer Pipeline Insight, 2024" report by DelveInsight outlines comprehensive insights of present clinical development scenarios and growth prospects across the Esophageal Cancer market. A detailed picture of the Esophageal Cancer pipeline landscape is provided, which includes the disease overview and Esophageal Cancer treatment guidelines.

Esophageal Cancer Epidemiology

DelveInsight's 'Esophageal Cancer Epidemiology Forecast to 2034' report delivers an in-depth understanding of the disease, historical and forecasted Esophageal Cancer epidemiology in the 7MM, i.e., the United States, EU5 (Germany, Spain, Italy, France, and the United Kingdom), and Japan.

About DelveInsight

DelveInsight is a leading Healthcare Business Consultant, and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.

It also offers Healthcare Consulting Services, which benefits in market analysis to accelerate the business growth and overcome challenges with a practical approach.

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