CDK12 Inhibitor Pipeline Insights Report: Latest Advancements, Key Players, and Strategic Developments in 2025

DelveInsight's, "CDK12 Pipeline Insight 2025" report provides comprehensive insights about 3+ companies and 3+ pipeline drugs in CDK12 pipeline landscape. It covers the CDK12 Pipeline drug profiles, including clinical and nonclinical stage products. It also covers the CDK12 Pipeline Therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

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Key Takeaways from the CDK12 Pipeline Report

* In August 2025, Marc Dall'Era, MD conducted a phase II trial studies how well niraparib, when given before surgery, works in treating patients with high risk prostate cancer that has not spread to other parts of the body (localized) and alterations in deoxyribonucleic acid (DNA) repair pathways. Niraparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
* DelveInsight's CDK12 Pipeline report depicts a robust space with 3+ active players working to develop 3+ pipeline therapies for CDK12 treatment.
* The leading CDK12 Companies such as Carrick Therapeutics, OnKure Therapeutics , and others.
* Promising CDK12 Therapies such as Pembrolizumab, Niraparib, Rucaparib and others.

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The CDK12 Pipeline Report provides disease overview, pipeline scenario and therapeutic assessment of the key pipeline therapies in this domain. The CDK12 Pipeline Report also highlights the unmet needs with respect to the CDK12.

CDK12 Overview

Cyclin-dependent kinase 12 (CDK12) is one of the 20 members of cyclin-dependent kinases (CDK). Each of CDKs binds with cyclin play important roles in the control of cell cycle and cell division and regulates transcription in response to various cellular processes. As a transcription associated CDK, CDK12 binds with cyclin K phosphorylate RNA Pol II at CTD promoting transcription elongation. CDK12 can also interact with RNA processing factors to regulate RNA splicing. Furthermore, CDK12 mediated phosphorylation of RNA Pol II couples mRNA 3 end processing to participate in transcription termination. Besides, CDK12 plays critical role in regulating intronic polyadenylation, epigenetics, as well as translation. CDK12 alterations were found in different human cancers.

CDK12 Emerging Drugs Profile

* CT7439: Carrick Therapeutics

CT7439 is an inhibitor of CDK12/13 as well as a 'glue degrader' of Cyclin-K, which is the obligate co-factor for CDK12/13, giving both first-in-class and best-in-class potential. This dual modality significantly increases the potency of the compound and leads to the inhibition of DNA repair at the transcriptional level. CDK12/13 regulates gene transcription through the activation of RNA Polymerase II. It has the potential to synergise with other agents targeting DDR such as the PARP inhibitors in multiple cancer types including breast, ovarian and Ewing's Sarcoma. Currently, the drug is in the Phase I/II stage of its development for the treatment of solid tumors.

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The CDK12 Pipeline report provides insights into:-

* The report provides detailed insights about companies that are developing therapies for the treatment of CDK12 with aggregate therapies developed by each company for the same.
* It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for CDK12 Treatment.
* CDK12 Companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
* CDK12 Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
* Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the CDK12 market.

CDK12 Companies

Carrick Therapeutics, OnKure Therapeutics , and others.

CDK12 Pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as,

* Intra-articular
* Intraocular
* Intrathecal
* Intravenous
* Oral
* Parenteral
* Subcutaneous
* Topical
* Transdermal

CDK12 Products have been categorized under various Molecule types such as,

* Oligonucleotide
* Peptide
* Small molecule

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Scope of the CDK12 Pipeline Report

* Coverage- Global
* CDK12 Companies- Carrick Therapeutics, OnKure Therapeutics , and others.
* Promising CDK12 Therapies such as Pembrolizumab, Niraparib, Rucaparib and others.
* CDK12 Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
* CDK12 Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III

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Table of Contents

* Introduction
* Executive Summary
* CDK12 Inhibitor: Overview
* Pipeline Therapeutics
* Therapeutic Assessment
* CDK12 Inhibitor - DelveInsight's Analytical Perspective
* Late Stage Products (Phase III)
* Drug Name: Company Name
* Drug profiles in the detailed report.....
* Mid Stage Products (Phase II)
* Drug Name: Company Name
* Drug profiles in the detailed report.....
* Early Stage Products (Phase I/II)
* Product Name: Company Name
* Preclinical Stage Products
* Drug Name: Company Name
* Drug profiles in the detailed report.....
* Inactive Products
* CDK12 Inhibitor Key Companies
* CDK12 Inhibitor Key Products
* CDK12 Inhibitor- Unmet Needs
* CDK12 Inhibitor- Market Drivers and Barriers
* CDK12 Inhibitor- Future Perspectives and Conclusion
* CDK12 Inhibitor Analyst Views
* CDK12 Inhibitor Key Companies Appendix

About Us

DelveInsight is a leading healthcare-focused market research and consulting firm that provides clients with high-quality market intelligence and analysis to support informed business decisions. With a team of experienced industry experts and a deep understanding of the life sciences and healthcare sectors, we offer customized research solutions and insights to clients across the globe. Connect with us to get high-quality, accurate, and real-time intelligence to stay ahead of the growth curve.

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