Press release
Targeted Protein Degradation Market to Reach USD 4.5 Billion by 2034, Growing at 20.8% CAGR
IntroductionTargeted protein degradation (TPD) is an innovative therapeutic modality that harnesses the body's natural protein disposal machinery to selectively eliminate disease-causing proteins. Unlike traditional small molecules that inhibit proteins, TPD enables the complete removal of "undruggable" proteins, opening new possibilities in oncology, neurology, immunology, and rare diseases.
With technologies such as PROTACs (Proteolysis Targeting Chimeras), molecular glues, and lysosome-targeting chimeras, the field is rapidly advancing. Fueled by venture capital investments, pharma partnerships, and expanding clinical pipelines, the targeted protein degradation market is set for exponential growth over the next decade.
Download Full PDF Sample Copy of Market Report @
https://exactitudeconsultancy.com/request-sample/72930
Market Overview
• Market Size (2024): USD 670 million (estimated)
• Forecast (2034): USD 4.5 billion
• CAGR (2024-2034): ~20.8%
Key Growth Drivers:
• Ability to target previously "undruggable" proteins.
• Rising prevalence of cancer, neurodegenerative, and autoimmune diseases.
• Expanding pipeline of TPD-based drugs in preclinical and clinical stages.
• Increasing pharma-biotech collaborations and licensing deals.
Challenges:
• Early-stage nature of most clinical candidates.
• Complexity in optimizing selectivity and safety profiles.
• Manufacturing challenges for bifunctional molecules (e.g., PROTACs).
Leading Companies:
Arvinas Inc., C4 Therapeutics, Nurix Therapeutics, Kymera Therapeutics, Monte Rosa Therapeutics, Dialectic Therapeutics, Bristol Myers Squibb, Novartis AG, Pfizer Inc., Amgen Inc.
Segmentation Analysis
By Technology
• PROTACs (Proteolysis Targeting Chimeras)
• Molecular Glues
• LYTACs (Lysosome Targeting Chimeras)
• Others (Degronimids, AUTACs, etc.)
By Application
• Oncology
• Neurodegenerative Diseases (Alzheimer's, Parkinson's)
• Autoimmune & Inflammatory Disorders
• Rare Diseases
• Others (cardiovascular, metabolic)
By Therapeutic Development Stage
• Preclinical
• Clinical (Phase I, II, III)
• Commercialized
By End User
• Pharmaceutical & Biotechnology Companies
• Academic & Research Institutes
• Contract Research Organizations (CROs)
Summary:
PROTACs dominate the current landscape, with several molecules advancing into clinical trials. Oncology remains the largest application segment, while neurodegenerative diseases and rare disorders are rapidly growing areas of research.
Explore Full Report here:
https://exactitudeconsultancy.com/reports/72930/targeted-protein-degradation-market
Regional Analysis
North America
• Largest market in 2024, driven by U.S.-based biotech hubs and NIH funding.
• Strong presence of TPD pioneers such as Arvinas and Kymera.
Europe
• Robust pipeline development in Switzerland, Germany, and the UK.
• EU research consortia supporting novel TPD platforms.
Asia-Pacific
• Fastest-growing region (CAGR ~22%) with increasing biotech innovation in China, Japan, and South Korea.
• Rising collaborations between Western firms and Asian CROs/CDMOs.
Middle East & Africa
• Early-stage adoption, with GCC countries exploring biotech partnerships.
• Limited R&D infrastructure in most regions.
Latin America
• Brazil and Mexico growing in early clinical research and academic collaborations.
Summary:
While North America and Europe dominate today's market, Asia-Pacific is emerging as the future growth engine, supported by biotech innovation, cost-effective clinical trials, and expanding research collaborations.
Market Dynamics
Key Growth Drivers
• Expanding clinical pipeline of PROTACs and molecular glues.
• Ability to tackle previously untreatable targets.
• Increasing VC investments and pharma partnerships.
• Strong research in oncology, rare, and neurodegenerative diseases.
Key Challenges
• Translational hurdles in moving from preclinical to clinical.
• Safety and off-target effects of bifunctional molecules.
• Scalability challenges in manufacturing novel TPD drugs.
Latest Trends
• Development of molecular glue degraders as next-gen therapies.
• Use of AI and computational biology to identify degron sites.
• Expansion into non-oncology indications such as neurodegeneration.
• Collaborations between biotech startups and big pharma for co-development.
Get Your Exclusive Offer with up to 10% Discount :
https://exactitudeconsultancy.com/checkout/?currency=USD&type=single_user_license&report_id=73116
Competitor Analysis
Major Players:
• Arvinas Inc.
• C4 Therapeutics
• Nurix Therapeutics
• Kymera Therapeutics
• Monte Rosa Therapeutics
• Dialectic Therapeutics
• Bristol Myers Squibb
• Novartis AG
• Pfizer Inc.
• Amgen Inc.
Competitive Landscape:
The market is innovation-driven and highly competitive, with Arvinas, Kymera, and C4 Therapeutics leading in PROTAC development. Large pharma companies including Novartis, Pfizer, and BMS are heavily investing through partnerships and licensing. Startups like Monte Rosa are pushing the boundaries of molecular glue technology. Strategic alliances and co-development deals are shaping the competitive environment.
Conclusion
The targeted protein degradation market is projected to grow from USD 670 million in 2024 to USD 4.5 billion by 2034, at a CAGR of 20.8%, making it one of the fastest-growing areas in drug discovery.
Despite challenges in clinical translation, safety, and manufacturing, the potential to eliminate undruggable targets positions TPD as a transformative approach. With oncology leading and neurodegeneration expanding, Asia-Pacific's rapid rise complements the strong innovation base in North America and Europe.
Key Takeaway: Companies that leverage PROTAC and molecular glue platforms, AI-driven discovery, and global pharma partnerships will be best positioned to lead the next decade of drug innovation through targeted protein degradation.
This report is also available in the following languages : Japanese (標的タンパク質分解), Korean (표적 단백질 분해), Chinese (靶向蛋白质降解), French (Dégradation ciblée des protéines), German (Gezielter Proteinabbau), and Italian (Degradazione proteica mirata), etc.
Request for a sample of this research report at (Use Corporate Mail ID for Quick Response) @
https://exactitudeconsultancy.com/request-sample/72930
Our More Reports:
PARP Inhibitors
https://exactitudeconsultancy.com/reports/73126/parp-inhibitors-market
Abuse Deterrent Formulations
https://exactitudeconsultancy.com/reports/73128/abuse-deterrent-formulations-market
T-Cell Therapy
https://exactitudeconsultancy.com/reports/73130/t-cell-therapy-market
About Us
Exactitude Consultancy is a market research & consulting services firm which helps its client to address their most pressing strategic and business challenges. Our market research helps clients to address critical business challenges and also helps make optimized business decisions with our fact-based research insights, market intelligence, and accurate data.
https://bulletin.exactitudeconsultancy.com/
https://www.thehealthanalytics.com/
https://www.analytica.global/
https://www.marketintelligencedata.com/
https://www.marketinsightsreports.com/
https://exactitudeconsultancy.com/
Connect Us:
Irfan Tamboli
PHONE NUMBER +1 (704) 266-3234
EMAIL ADDRESS: sales@exactitudeconsultancy.com
This release was published on openPR.
Permanent link to this press release:
Copy
Please set a link in the press area of your homepage to this press release on openPR. openPR disclaims liability for any content contained in this release.
You can edit or delete your press release Targeted Protein Degradation Market to Reach USD 4.5 Billion by 2034, Growing at 20.8% CAGR here
News-ID: 4205740 • Views: …
More Releases from Exactitude Consultancy
Vacuum Insulated Pipe Market Projected to Reach USD 2.36 Billion by 2034
Introduction: A Market Built on Cryogenic Efficiency and Innovation
The global Vacuum Insulated Pipe (VIP) market is witnessing a steady surge driven by the expanding cryogenic industry, increased liquefied natural gas (LNG) trade, and rising demand for efficient liquid gas transportation systems. These specialized double-wall pipes, engineered with high vacuum insulation between inner and outer layers, have become indispensable in industries handling cryogenic fluids such as liquid nitrogen, oxygen, argon, and…
Solar PV Mounting Systems Market is Expected to Reach USD 31.7 Billion by 2034
Introduction: Powering the Next Decade of Solar Expansion
The Solar PV Mounting Systems Market is emerging as a crucial pillar in the clean energy revolution, enabling efficient, cost-effective, and durable installations of photovoltaic (PV) modules across rooftops, open fields, and floating structures. As the world accelerates toward carbon neutrality, the demand for robust, modular, and adaptable mounting systems has intensified across residential, commercial, and utility-scale solar projects.
Download Full PDF Sample Copy…
Tall Oil Fatty Acid Market projected to reach USD 2.21 billion by 2034
Introduction: A Sustainable Feedstock Powering the Future of Bio-based Chemicals
The Tall Oil Fatty Acid (TOFA) Market is gaining strong traction as industries increasingly shift toward renewable, sustainable, and bio-based chemical alternatives. Derived as a byproduct from the kraft pulping process of pine wood, TOFA has become a vital raw material in the production of alkyd resins, dimer acids, lubricants, coatings, and adhesives. Its unique composition-rich in oleic and linoleic acids-makes…
Lithium-Ion Battery Recycling Market Projected to Reach USD 27.3 Billion by 2034
Introduction: Powering the Circular Energy Transition
As the world accelerates toward electrification and clean energy, the demand for lithium-ion batteries has skyrocketed-fueling everything from electric vehicles (EVs) to smartphones and grid storage systems. However, this exponential growth brings with it an urgent environmental challenge: how to sustainably manage end-of-life batteries.
Download Full PDF Sample Copy of Market Report @ https://exactitudeconsultancy.com/request-sample/25354
The Lithium-Ion Battery Recycling Market has emerged as a cornerstone of the global…
More Releases for Therapeutic
Exosome Therapeutic Market : Detailed Overview
Introduction:
The exosome therapeutic market is a rapidly emerging segment in the field of regenerative medicine and drug delivery. Exosomes are extracellular vesicles naturally released by cells that play a crucial role in cell communication and genetic material transfer. They have gained attention for their potential applications in treating various diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions. As a novel therapeutic platform, exosomes provide significant advantages such as low immunogenicity,…
Parkinson's Disease Therapeutic Market Hope for Patients: The Parkinson's Diseas …
Parkinson's Disease Therapeutic Market worth $6.51 Bn by 2031 - Exclusive Report by InsightAce Analytic Pvt. Ltd.
InsightAce Analytic Pvt. Ltd. announces the release of a market assessment report on the "Global Parkinson's Disease Therapeutic Market - (By Drugs (Carbidopa-levodopa, Dopamine agonists, Mao-b inhibitors, COMT inhibitors, Anticholinergics, Others), By Distribution Channel (Hospital pharmacy, Retail pharmacy, Online pharmacy), By Brand (Branded, Generics), By Route of Administration (Oral, Injectable, Intestinal Infusion, Subcutaneous, Others)),…
Global Remote Therapeutic Monitoring Market
According to a new market research report published by Global Market Estimates, the Global Remote Therapeutic Monitoring Market is projected to grow at a CAGR of 17.4% from 2023 to 2028.
Medsien, Intellihinc, Zimmer Biomet, Owlytics Healthcare, Limber Health, Medistics, RxCap, Propeller Health, HealthArc, CENSON Health, and B Castle Smith & Co., are some of the key players in the remote therapeutic monitoring market.
Browse 147 Market Data Tables and 115…
Europe Digital Therapeutic (DTx) Market
Europe Digital Therapeutic (DTx) Market report provides information about the industry, including valuable Analysis and Detailed study. This research study explores the Global Europe Digital Therapeutic (DTx) Market in detail such as industry chain structures, raw material suppliers, with manufacturing. The Europe Digital Therapeutic (DTx) market examines the primary segments of the market. This intelligent study provides historical data from forecast.It also provides the details such as whether the customers…
Recombinant Therapeutic Antibodies and Proteins Market continues to expand with …
Recombinant therapeutic protein drugs are an important class of medicines, which helps patients in need of novel therapies. Recently approved recombinant protein therapeutics have been developed to treat a wide variety of clinical indications, including cancers, inflammation/autoimmunity, genetic disorders, and exposure to infectious agents. The latest advancements in protein-engineering technologies have allowed drug manufacturers and developers to adjust desirable functional characteristics of proteins of interest maintaining product efficacy. Protein-based therapies…
Therapeutic Vaccine Market 2020 - 2028 Top Companies Agenus Inc., Argos Therapeu …
This detailed market study covers therapeutic vaccine market growth potentials which can assist the stake holders to understand key trends and prospects in therapeutic vaccine market identifying the growth opportunities and competitive scenarios. The report also focuses on data from different primary and secondary sources, and is analyzed using various tools. It helps to gain insights into the market's growth potential, which can help investors identify scope and opportunities. The…
