Press release
From mechanism of action to prospective immunotherapeutic methods, TIGIT in cancer
TIGIT Inhibitors Market
The field of immuno-oncology has revolutionized cancer treatment, with checkpoint inhibitors such as PD-1, PD-L1, and CTLA-4 therapies transforming outcomes for patients with advanced malignancies. However, many patients still fail to respond or develop resistance, underscoring the need for new immune checkpoint targets. T-cell immunoreceptor with Ig and ITIM domains (TIGIT) has emerged as one of the most promising next-generation targets, showing strong potential to enhance anti-tumor immunity when combined with PD-1/PD-L1 inhibitors.
Over the next decade, the TIGIT inhibitors market is expected to expand significantly, driven by increasing clinical trial activity, rising cancer incidence, and growing collaborations between global pharmaceutical leaders and biotech innovators.
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Market Overview
• The global TIGIT inhibitors market size in 2024 is estimated at USD 210 million.
• It is projected to reach USD 3.2 billion by 2034, growing at a striking CAGR of 31.1 % during the forecast period.
• Growth is supported by robust pipelines, particularly in non-small cell lung cancer (NSCLC), melanoma, and other solid tumors.
Key Market Drivers:
• Rising prevalence of cancer worldwide.
• Expanding immuno-oncology pipeline with multiple TIGIT inhibitor candidates.
• Strong synergy of TIGIT inhibitors with PD-1/PD-L1 checkpoint blockade.
• Increasing investment in clinical trials and global collaborations.
Key Challenges:
• Limited late-stage clinical trial successes to date.
• Safety and tolerability concerns in combination regimens.
• High R&D and clinical trial costs.
Leading Players:
Roche/Genentech, Merck & Co., Bristol Myers Squibb, Gilead Sciences, BeiGene, Innovent Biologics, Arcus Biosciences, Compugen, and Iteos Therapeutics.
Segmentation Analysis
The TIGIT inhibitors market can be segmented as follows:
By Drug Type
• Monoclonal Antibodies
• Bispecific Antibodies (TIGIT + PD-1/PD-L1)
• Others (fusion proteins, experimental formats)
By Cancer Indication
• Non-Small Cell Lung Cancer (NSCLC)
• Melanoma
• Head & Neck Squamous Cell Carcinoma
• Colorectal Cancer
• Others (hematologic malignancies, urothelial carcinoma)
By End-Use
• Hospitals
• Cancer Treatment Centers
• Research & Academic Institutes
Summary:
Monoclonal antibodies dominate current pipelines, but bispecific antibodies targeting TIGIT and PD-1/PD-L1 simultaneously are gaining strong interest due to their potential for improved efficacy. NSCLC remains the largest therapeutic focus, though melanoma and other cancers represent key growth areas.
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Regional Analysis
North America
• Largest market, accounting for ~50 % of global revenues in 2024.
• Strong clinical trial presence, especially in the U.S.
• Robust investment in immuno-oncology R&D by major players such as Merck, BMS, and Genentech.
Europe
• Significant adoption in Germany, France, and the UK, supported by EMA's rare disease and oncology frameworks.
• Expanding partnerships between European biotech startups and pharma leaders.
Asia-Pacific (APAC)
• Expected to record the fastest CAGR (~34.2 %) during 2024-2034.
• China is a major hub, with BeiGene and Innovent Biologics leading TIGIT-focused pipelines.
• Expanding oncology trials in Japan, South Korea, and India.
Middle East & Africa (MEA)
• Early adoption stage, with oncology growth driven by rare disease and immunotherapy programs in Gulf nations.
Latin America
• Brazil and Mexico lead in clinical adoption, with growing involvement in international immuno-oncology studies.
Regional Summary:
North America and Europe dominate current revenues, but Asia-Pacific will be the fastest-growing hub, fueled by biotech innovation and rapidly expanding cancer patient populations.
Market Dynamics
Growth Drivers
1. Increasing cancer incidence globally (19+ million new cases annually).
2. Strong therapeutic synergy of TIGIT inhibitors with PD-1/PD-L1 drugs.
3. Expanding pipeline with dozens of clinical trials underway.
4. Rising investments in immuno-oncology from both pharma and biotech firms.
Key Challenges
• Clinical trial attrition and regulatory hurdles.
• Safety profile concerns in immune-related adverse events.
• Pricing and reimbursement issues in oncology markets.
Latest Trends
• Development of bispecific and multispecific antibodies targeting TIGIT in combination with PD-1, LAG-3, and other checkpoints.
• Increasing use of biomarker-driven patient selection to improve trial success.
• Growth in strategic licensing and partnership agreements between biotech startups and large pharma.
• Exploration of TIGIT inhibition in autoimmune diseases beyond oncology.
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Competitor Analysis
Major Players:
• Roche/Genentech (tiragolumab - leading TIGIT inhibitor candidate).
• Merck & Co. (pipeline combination studies with Keytruda).
• Bristol Myers Squibb (early-stage TIGIT programs).
• Gilead Sciences & Arcus Biosciences (domvanalimab, in advanced trials).
• BeiGene (ociperlimab - extensive development in China).
• Innovent Biologics (pipeline TIGIT inhibitors for NSCLC).
• Compugen (preclinical and clinical checkpoint programs).
• Iteos Therapeutics (EOS-448 - bispecific development).
Competitive Summary:
The market is highly innovation-driven, with Roche's tiragolumab and Arcus/Gilead's domvanalimab leading the race. Asian players like BeiGene and Innovent are shaping APAC's rapid growth, while U.S. biotech firms such as Arcus, Compugen, and Iteos are advancing differentiated approaches. Partnerships and co-development deals are critical for trial funding and accelerating commercialization.
Conclusion
The TIGIT inhibitors market is projected to grow from USD 210 million in 2024 to USD 3.2 billion by 2034, at a CAGR of 31.1 %.
This report is also available in the following languages : Japanese (TIGIT阻害剤市場), Korean (TIGIT 억제제 시장), Chinese (TIGIT抑制剂市场), French (Marché des inhibiteurs TIGIT), German (Markt für TIGIT-Inhibitoren), and Italian (Mercato degli inibitori TIGIT), etc.
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