Press release
Primary Progressive Multiple Sclerosis (PPMS) Market is expected to reach USD 6.1 billion by 2034
Primary Progressive Multiple Sclerosis
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Until recently, treatment options for PPMS were extremely limited, focusing only on symptom management. The approval of ocrelizumab (Ocrevus) in 2017 marked the first disease-modifying therapy (DMT) for PPMS, revolutionizing care. Since then, ongoing research in biologics, gene therapy, remyelination agents, and digital health monitoring is driving optimism for more effective treatment pathways. Between 2024 and 2034, the PPMS market is expected to expand strongly, supported by advancing therapeutic innovation, rising prevalence of MS globally, and expanding access to neurology care.
Market Overview
• Market Size 2024: USD 2.8 billion (estimated)
• Forecasted Market Size 2034: USD 6.1 billion
• CAGR (2024-2034): 8.1%
Key Highlights
• Ocrelizumab remains the cornerstone therapy for PPMS, with strong adoption in North America and Europe.
• Emerging therapies include BTK inhibitors, stem cell therapies, and remyelination agents.
• Rising prevalence of MS, with 2.8 million people affected worldwide, expanding the PPMS patient pool.
• Digital neurology and real-world data platforms improving disease tracking and treatment outcomes.
Segmentation Analysis
By Product
• Disease-modifying therapies (DMTs)
o Ocrelizumab (Ocrevus)
o Emerging BTK inhibitors (evobrutinib, tolebrutinib, fenebrutinib - pipeline)
o Stem cell and regenerative therapies
o Gene therapy approaches (pipeline)
• Symptomatic treatments (spasticity management, fatigue therapies, mobility aids)
• Digital health and monitoring tools
By Platform
• Hospital pharmacies
• Retail pharmacies
• Specialty clinics
• Online pharmacies
By Technology
• Monoclonal antibodies (mAbs)
• Small-molecule BTK inhibitors
• Stem cell transplantation and regenerative medicine
• Digital and AI-powered neurology tools
By End Use
• Hospitals and neurology centers
• Specialty MS clinics
• Homecare and tele-neurology platforms
By Application
• Early-diagnosed PPMS
• Mid-stage progressive PPMS
• Advanced disability management
Summary:
Today, ocrelizumab dominates the PPMS market, but BTK inhibitors, gene therapies, and remyelination approaches are expected to reshape the landscape over the next decade.
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Regional Analysis
North America
• Largest market share in 2024, led by the U.S. with widespread adoption of Ocrevus and strong reimbursement frameworks.
• Robust presence of MS advocacy groups supporting clinical trial recruitment and awareness.
Europe
• Germany, France, and the UK are major hubs for PPMS research and therapy adoption.
• EU's orphan drug and rare-disease policies accelerating pipeline development.
Asia-Pacific
• Fastest-growing region (CAGR ~9.4%), with rising MS prevalence and expanding healthcare infrastructure in Japan, China, and India.
• Increasing adoption of biologics and tele-neurology platforms for long-term management.
Middle East & Africa
• Limited infrastructure but growing diagnosis and treatment capacity.
• NGO and government-backed initiatives supporting neurology services.
Latin America
• Brazil and Mexico lead adoption in the region, supported by expanding healthcare investment.
• Growing availability of biosimilars improving affordability.
Summary:
While North America and Europe dominate, Asia-Pacific will be the fastest-growing region, fueled by population expansion, MS awareness, and access to advanced therapies.
Market Dynamics
Key Growth Drivers
• Increasing prevalence of multiple sclerosis globally.
• Expanding use of ocrelizumab and pipeline BTK inhibitors.
• Growing research in gene therapies and stem cell approaches.
• Digital health tools improving monitoring and adherence.
Key Challenges
• High therapy costs limiting access in developing regions.
• Lack of curative treatment - current drugs only slow progression.
• Side effects and safety concerns with long-term biologic use.
• Small PPMS patient pool compared to other MS subtypes, complicating trials.
Latest Trends
• Development of next-generation BTK inhibitors for progressive MS.
• Growing investment in remyelination and neuroprotective therapies.
• Increasing role of AI and digital biomarkers in early PPMS detection.
• Patient-centered models integrating tele-neurology and real-world data.
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Competitor Analysis
Major Players
• Roche Holding AG (Ocrevus - ocrelizumab, market leader)
• Novartis AG (BTK inhibitor pipeline)
• Sanofi S.A. (tolebrutinib, late-stage development)
• Merck KGaA (evobrutinib, clinical pipeline)
• Biogen Inc. (broad MS portfolio, remyelination research)
• Atara Biotherapeutics, Inc. (cell therapy approaches)
• TG Therapeutics, Inc. (ublituximab - novel monoclonal antibody)
• Genentech, Inc. (subsidiary of Roche, driving Ocrevus development)
• Bayer AG (neurology pipeline expansion)
• Smaller biotech firms focusing on regenerative and gene therapy approaches.
Summary:
The PPMS market is dominated by Roche with Ocrevus, but competition is intensifying as Novartis, Sanofi, Merck, and Biogen advance BTK inhibitors and regenerative therapies. Startups in gene and stem cell therapy are pushing disruptive innovation.
Conclusion
The primary progressive multiple sclerosis (PPMS) market is projected to grow from USD 2.8 billion in 2024 to USD 6.1 billion by 2034, at a CAGR of 8.1%. Advances in biologics, small-molecule inhibitors, and regenerative medicine will continue to transform treatment approaches.
Key Takeaways:
• North America leads the market, while Asia-Pacific grows fastest.
• Ocrelizumab dominates today, but BTK inhibitors and regenerative therapies are the next big drivers.
• High costs and small patient population remain significant challenges.
• Competitive focus lies in long-term disease modification, remyelination, and digital health integration.
Looking ahead, the PPMS market will evolve from reliance on a single biologic therapy toward multi-modal treatment strategies, including next-gen inhibitors, regenerative medicine, and AI-enabled monitoring, offering new hope to patients living with this difficult-to-treat condition.
This report is also available in the following languages : Japanese (一次性進行性多発性硬化症(PPMS)市場), Korean (원발성 진행성 다발성 경화증(PPMS) 시장), Chinese (原发性进行性多发性硬化症(PPMS)市场), French (Marché de la sclérose en plaques progressive primaire (SEP-PP)), German (Markt für primär progrediente Multiple Sklerose (PPMS)), and Italian (Mercato della sclerosi multipla progressiva primaria (PPMS)), etc.
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